Biology:FOXA3
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Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Hepatocyte nuclear factor 3-gamma (HNF-3G), also known as forkhead box protein A3 (FOXA3) or transcription factor 3G (TCF-3G) is a protein that in humans is encoded by the FOXA3 gene.[1][2]
Function
HNF-3G is a member of the forkhead class of DNA-binding proteins. These hepatocyte nuclear factors are transcriptional activators for liver-specific transcripts such as albumin and transthyretin, and they also interact with chromatin. Similar family members in mice have roles in the regulation of metabolism and in the differentiation of the pancreas and liver.[1]
References
- ↑ 1.0 1.1 "Entrez Gene: forkhead box A3". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3171.
- ↑ "Assignment of the human genes for hepatocyte nuclear factor 3-alpha, -beta, and -gamma (HNF3A, HNF3B, HNF3G) to 14q12-q13, 20p11, and 19q13.2-q13.4". Genomics 39 (3): 417–9. February 1997. doi:10.1006/geno.1996.4477. PMID 9119385.
Further reading
- "Effect of human erythrocyte stromata on complement activation.". Br. J. Haematol. 29 (2): 235–41. 1975. doi:10.1111/j.1365-2141.1975.tb01817.x. PMID 33.
- "A hepatocyte nuclear factor-3 site in the fibrinogen beta promoter is important for interleukin 6-induced expression, and its activity is influenced by the adjacent -148C/T polymorphism.". J. Biol. Chem. 280 (17): 16763–71. 2005. doi:10.1074/jbc.M501973200. PMID 15737987.
- "Co-crystal structure of the HNF-3/fork head DNA-recognition motif resembles histone H5.". Nature 364 (6436): 412–20. 1993. doi:10.1038/364412a0. PMID 8332212. Bibcode: 1993Natur.364..412C.
- "Analysis of hepatocyte nuclear factor-3 beta protein domains required for transcriptional activation and nuclear targeting.". Nucleic Acids Res. 23 (7): 1184–91. 1995. doi:10.1093/nar/23.7.1184. PMID 7739897.
- "Transcriptional regulation of human CYP3A4 basal expression by CCAAT enhancer-binding protein alpha and hepatocyte nuclear factor-3 gamma.". Mol. Pharmacol. 63 (5): 1180–9. 2003. doi:10.1124/mol.63.5.1180. PMID 12695546.
- "Genetic predictors of interindividual variability in hepatic CYP3A4 expression.". J. Pharmacol. Exp. Ther. 332 (3): 1088–99. 2010. doi:10.1124/jpet.109.160804. PMID 19934400.
- "Differentiation of insulin-producing cells from human neural progenitor cells.". PLOS Med. 2 (4): e103. 2005. doi:10.1371/journal.pmed.0020103. PMID 15839736.
- "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1–2): 149–56. 1997. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- "Differential binding and co-binding pattern of FOXA1 and FOXA3 and their relation to H3K4me3 in HepG2 cells revealed by ChIP-seq.". Genome Biol. 10 (11): R129. 2009. doi:10.1186/gb-2009-10-11-r129. PMID 19919681.
- "Foxp2 inhibits Nkx2.1-mediated transcription of SP-C via interactions with the Nkx2.1 homeodomain.". Am. J. Respir. Cell Mol. Biol. 38 (6): 750–8. 2008. doi:10.1165/rcmb.2007-0350OC. PMID 18239190.
- "The human HNF-3 genes: cloning, partial sequence and mutation screening in patients with impaired glucose homeostasis.". Hum. Hered. 50 (6): 370–81. 2000. doi:10.1159/000022943. PMID 10899756.
- Kaestner KH (2000). "The hepatocyte nuclear factor 3 (HNF3 or FOXA) family in metabolism.". Trends Endocrinol. Metab. 11 (7): 281–5. doi:10.1016/S1043-2760(00)00271-X. PMID 10920385.
- "The role of HNF1alpha, HNF3gamma, and cyclic AMP in glucose-6-phosphatase gene activation.". Biochemistry 36 (46): 14096–106. 1997. doi:10.1021/bi9703249. PMID 9369482.
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334.
- "HMGB1 interacts with many apparently unrelated proteins by recognizing short amino acid sequences.". J. Biol. Chem. 277 (9): 7021–8. 2002. doi:10.1074/jbc.M108417200. PMID 11748221.
- "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1–2): 171–4. 1994. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2002. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "Targeted disruption of the gene encoding hepatocyte nuclear factor 3gamma results in reduced transcription of hepatocyte-specific genes.". Mol. Cell. Biol. 18 (7): 4245–51. 1998. doi:10.1128/mcb.18.7.4245. PMID 9632808.
- "Drosophila forkhead homologues are expressed in a lineage-restricted manner in human hematopoietic cells.". Blood 81 (11): 2854–9. 1993. doi:10.1182/blood.V81.11.2854.2854. PMID 8499623.
External links
- Overview of all the structural information available in the PDB for UniProt: P55318 (Hepatocyte nuclear factor 3-gamma) at the PDBe-KB.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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