Biology:PHF1
From HandWiki
Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
PHD finger protein 1 is a protein that in humans is encoded by the PHF1 gene.[1][2][3]
Function
This gene encodes a protein with significant sequence similarity to Drosophila Polycomblike. The encoded protein contains a zinc finger-like PHD (plant homeodomain) finger which is distinct from other classes of zinc finger motifs and which shows the typical Cys4-His-Cys3 arrangement. PHD finger genes are thought to belong to a diverse group of transcriptional regulators possibly affecting eukaryotic gene expression by influencing chromatin structure. Two transcript variants have been found for this gene.[3]
References
- ↑ "The identification and localization of a human gene with sequence similarity to Polycomblike of Drosophila melanogaster". Genomics 48 (3): 381–3. March 1998. doi:10.1006/geno.1997.5201. PMID 9545646.
- ↑ "A polycomb group protein, PHF1, is involved in the response to DNA double-strand breaks in human cell". Nucleic Acids Research 36 (9): 2939–47. May 2008. doi:10.1093/nar/gkn146. PMID 18385154.
- ↑ 3.0 3.1 "Entrez Gene: PHF1 PHD finger protein 1". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5252.
Further reading
- "Role of hPHF1 in H3K27 methylation and Hox gene silencing". Molecular and Cellular Biology 28 (5): 1862–72. March 2008. doi:10.1128/MCB.01589-07. PMID 18086877.
- "Polycomblike PHD fingers mediate conserved interaction with enhancer of zeste protein". The Journal of Biological Chemistry 276 (46): 43065–73. November 2001. doi:10.1074/jbc.M104294200. PMID 11571280.
- "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. October 1997. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1–2): 171–4. January 1994. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
External links
- PHF1+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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