Biology:Myocyte-specific enhancer factor 2A

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Short description: Protein-coding gene in the species Homo sapiens


A representation of the 3D structure of the protein myoglobin showing turquoise α-helices.
Generic protein structure example

Myocyte-specific enhancer factor 2A is a protein that in humans is encoded by the MEF2A gene.[1][2] MEF2A is a transcription factor in the Mef2 family. In humans it is located on chromosome 15q26. Certain mutations in MEF2A cause an autosomal dominant form of coronary artery disease and myocardial infarction.

Function

The process of differentiation from mesodermal precursor cells to myoblasts has led to the discovery of a variety of tissue-specific factors that regulate muscle gene expression. The myogenic basic helix-loop-helix proteins, including myoD (MIM 159970), myogenin (MIM 159980), MYF5 (MIM 159990), and MRF4 (MIM 159991) are 1 class of identified factors. A second family of DNA binding regulatory proteins is the myocyte-specific enhancer factor-2 (MEF2) family. Each of these proteins binds to the MEF2 target DNA sequence present in the regulatory regions of many, if not all, muscle-specific genes. The MEF2 genes are members of the MADS gene family (named for the yeast mating type-specific transcription factor MCM1, the plant homeotic genes 'agamous' and 'deficiens' and the human serum response factor SRF (MIM 600589)), a family that also includes several homeotic genes and other transcription factors, all of which share a conserved DNA-binding domain.[supplied by OMIM][2]

Interactions

Myocyte-specific enhancer factor 2A has been shown to interact with:


References

  1. "Human myocyte-specific enhancer factor 2 comprises a group of tissue-restricted MADS box transcription factors". Genes Dev 6 (9): 1783–98. October 1992. doi:10.1101/gad.6.9.1783. PMID 1516833. 
  2. 2.0 2.1 "Entrez Gene: MEF2A MADS box transcription enhancer factor 2, polypeptide A (myocyte enhancer factor 2A)". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4205. 
  3. "Functional and physical interactions between mammalian achaete-scute homolog 1 and myocyte enhancer factor 2A". J. Biol. Chem. 271 (24): 14371–5. June 1996. doi:10.1074/jbc.271.24.14371. PMID 8662987. 
  4. 4.0 4.1 "p300/cAMP-response-element-binding-protein ('CREB')-binding protein (CBP) modulates co-operation between myocyte enhancer factor 2A (MEF2A) and thyroid hormone receptor-retinoid X receptor". Biochem. J. 369 (Pt 3): 477–84. February 2003. doi:10.1042/BJ20020057. PMID 12371907. 
  5. 5.0 5.1 "HDAC4 deacetylase associates with and represses the MEF2 transcription factor". EMBO J. 18 (18): 5099–107. September 1999. doi:10.1093/emboj/18.18.5099. PMID 10487761. 
  6. 6.0 6.1 6.2 "mHDA1/HDAC5 histone deacetylase interacts with and represses MEF2A transcriptional activity". J. Biol. Chem. 275 (20): 15594–9. May 2000. doi:10.1074/jbc.M908437199. PMID 10748098. https://hal.archives-ouvertes.fr/hal-00379796/document. 
  7. "Regulation of the MEF2 family of transcription factors by p38". Mol. Cell. Biol. 19 (1): 21–30. January 1999. doi:10.1128/mcb.19.1.21. PMID 9858528. 
  8. "Targeting of p38 mitogen-activated protein kinases to MEF2 transcription factors". Mol. Cell. Biol. 19 (6): 4028–38. June 1999. doi:10.1128/mcb.19.6.4028. PMID 10330143. 
  9. "MEF2 protein expression, DNA binding specificity and complex composition, and transcriptional activity in muscle and non-muscle cells". J. Biol. Chem. 271 (40): 24927–33. October 1996. doi:10.1074/jbc.271.40.24927. PMID 8798771. 
  10. "Smad proteins function as co-modulators for MEF2 transcriptional regulatory proteins". Nucleic Acids Res. 29 (3): 732–42. February 2001. doi:10.1093/nar/29.3.732. PMID 11160896. 

Further reading

External links