Biology:HOXB13
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Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Homeobox protein Hox-B13 is a protein that in humans is encoded by the HOXB13 gene.[1][2][3]
Function
This gene encodes a transcription factor that belongs to the homeobox gene family. Genes of this family are highly conserved among vertebrates and essential for vertebrate embryonic development. This gene has been implicated in fetal skin development and cutaneous regeneration. In mice, a similar gene was shown to exhibit temporal and spatial colinearity in the main body axis of the embryo, but was not expressed in the secondary axes, which suggests functions in body patterning along the axis. This gene and other HOXB genes form a gene cluster on chromosome 17 in the 17q21-22 region.[3] Men who inherit a rare (<0.1% in a selected group of patients without clinical signs of prostate cancer) genetic variant in HOXB13 (G84E or rs138213197) have a 10-20-fold increased risk of prostate cancer.[4][5]
See also
References
- ↑ "Hoxb-13: a new Hox gene in a distant region of the HOXB cluster maintains colinearity". Development 122 (8): 2475–84. Aug 1996. doi:10.1242/dev.122.8.2475. PMID 8756292.
- ↑ "Modulation of the human homeobox genes PRX-2 and HOXB13 in scarless fetal wounds". The Journal of Investigative Dermatology 111 (1): 57–63. Jul 1998. doi:10.1046/j.1523-1747.1998.00238.x. PMID 9665387.
- ↑ 3.0 3.1 "Entrez Gene: HOXB13 homeobox B13". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10481.
- ↑ "Germline mutations in HOXB13 and prostate-cancer risk". The New England Journal of Medicine 366 (2): 141–9. Jan 2012. doi:10.1056/NEJMoa1110000. PMID 22236224.
- ↑ "Prostate cancer risk variants of the HOXB genetic locus". Scientific Reports 11 (1): 11385. May 2021. doi:10.1038/s41598-021-89399-7. PMID 34059701. Bibcode: 2021NatSR..1111385D.
Further reading
- "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene 138 (1–2): 171–4. Jan 1994. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
- "AbdB-like Hox proteins stabilize DNA binding by the Meis1 homeodomain proteins". Molecular and Cellular Biology 17 (11): 6448–58. Nov 1997. doi:10.1128/MCB.17.11.6448. PMID 9343407.
- "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene 200 (1–2): 149–56. Oct 1997. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- "Complete mutation analysis panel of the 39 human HOX genes". Teratology 65 (2): 50–62. Feb 2002. doi:10.1002/tera.10009. PMID 11857506.
- "HOXB13 homeodomain protein is cytoplasmic throughout fetal skin development". Developmental Dynamics 227 (2): 192–202. Jun 2003. doi:10.1002/dvdy.10290. PMID 12761847.
- "HOXB13 homeodomain protein suppresses the growth of prostate cancer cells by the negative regulation of T-cell factor 4". Cancer Research 64 (9): 3046–51. May 2004. doi:10.1158/0008-5472.CAN-03-2614. PMID 15126340.
- "HOXB13 induces growth suppression of prostate cancer cells as a repressor of hormone-activated androgen receptor signaling". Cancer Research 64 (24): 9185–92. Dec 2004. doi:10.1158/0008-5472.CAN-04-1330. PMID 15604291.
- "Regulation of tumor invasion by HOXB13 gene overexpressed in human endometrial cancer". Oncology Reports 13 (4): 721–6. Apr 2005. doi:10.3892/or.13.4.721. PMID 15756448. http://amcor.asahikawa-med.ac.jp/modules/xoonips/download.php?id=K335.
- "HOXB13 is downregulated in colorectal cancer to confer TCF4-mediated transactivation". British Journal of Cancer 92 (12): 2233–9. Jun 2005. doi:10.1038/sj.bjc.6602631. PMID 15928669.
- "Genomic testing for sensitivity of breast cancer to hormonal therapy". Clinical Cancer Research 12 (7 Pt 1): 1954–5. Apr 2006. doi:10.1158/1078-0432.CCR-06-0289. PMID 16609001.
- "A two-gene expression ratio of homeobox 13 and interleukin-17B receptor for prediction of recurrence and survival in women receiving adjuvant tamoxifen". Clinical Cancer Research 12 (7 Pt 1): 2080–7. Apr 2006. doi:10.1158/1078-0432.CCR-05-1263. PMID 16609019.
- "The homeobox HOXB13 is expressed in human minor salivary gland". Oral Diseases 12 (4): 424–7. Jul 2006. doi:10.1111/j.1601-0825.2005.01218.x. PMID 16792730.
- "The HOXB13:IL17BR expression index is a prognostic factor in early-stage breast cancer". Journal of Clinical Oncology 24 (28): 4611–9. Oct 2006. doi:10.1200/JCO.2006.06.6944. PMID 17008703.
- "Epigenetic silencing of novel tumor suppressors in malignant melanoma". Cancer Research 66 (23): 11187–93. Dec 2006. doi:10.1158/0008-5472.CAN-06-1274. PMID 17145863.
- "HOXB13 promotes ovarian cancer progression". Proceedings of the National Academy of Sciences of the United States of America 104 (43): 17093–8. Oct 2007. doi:10.1073/pnas.0707938104. PMID 17942676. Bibcode: 2007PNAS..10417093M.
- "Germline mutations in HOXB13 and prostate-cancer risk". The New England Journal of Medicine 366 (2): 141–9. Jan 2012. doi:10.1056/NEJMoa1110000. PMID 22236224.
External links
- HOXB13+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
- Overview of all the structural information available in the PDB for UniProt: Q92826 (Homeobox protein Hox-B13) at the PDBe-KB.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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