Biology:Retinoblastoma-like protein 2
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Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Retinoblastoma-like protein 2 is a protein that in humans is encoded by the RBL2 gene.[1][2]
Interactions
Retinoblastoma-like protein 2 has been shown to interact with:
- BRCA1,[3]
- BRF1[4]
- C-Raf,[5]
- Cyclin E1,[6][7]
- Cyclin-dependent kinase 2,[6][8]
- HDAC1,[9][10]
- Prohibitin,[11] and
- RBBP8.[12][13]
See also
References
- ↑ "Cloning of a new member of the retinoblastoma gene family (pRb2) which binds to the E1A transforming domain". Oncogene 8 (9): 2561–6. Sep 1993. PMID 8361765.
- ↑ "Genomic structure of the human retinoblastoma-related Rb2/p130 gene". Proceedings of the National Academy of Sciences of the United States of America 93 (10): 4629–32. May 1996. doi:10.1073/pnas.93.10.4629. PMID 8643454. Bibcode: 1996PNAS...93.4629B.
- ↑ "Disruption of BRCA1 LXCXE motif alters BRCA1 functional activity and regulation of RB family but not RB protein binding". Oncogene 20 (35): 4827–41. Aug 2001. doi:10.1038/sj.onc.1204666. PMID 11521194.
- ↑ "RNA polymerase III transcription factor IIIB is a target for repression by pocket proteins p107 and p130". Molecular and Cellular Biology 19 (6): 4255–61. Jun 1999. doi:10.1128/mcb.19.6.4255. PMID 10330166.
- ↑ "Raf-1 physically interacts with Rb and regulates its function: a link between mitogenic signaling and cell cycle regulation". Molecular and Cellular Biology 18 (12): 7487–98. Dec 1998. doi:10.1128/mcb.18.12.7487. PMID 9819434.
- ↑ 6.0 6.1 "Cyclin E associates with BAF155 and BRG1, components of the mammalian SWI-SNF complex, and alters the ability of BRG1 to induce growth arrest". Molecular and Cellular Biology 19 (2): 1460–9. Feb 1999. doi:10.1128/mcb.19.2.1460. PMID 9891079.
- ↑ "The adenovirus E1A-associated 130-kD protein is encoded by a member of the retinoblastoma gene family and physically interacts with cyclins A and E". Genes & Development 7 (12A): 2366–77. Dec 1993. doi:10.1101/gad.7.12a.2366. PMID 8253383.
- ↑ "Identification of a p130 domain mediating interactions with cyclin A/cdk 2 and cyclin E/cdk 2 complexes". Oncogene 14 (20): 2395–406. May 1997. doi:10.1038/sj.onc.1201085. PMID 9188854.
- ↑ "The three members of the pocket proteins family share the ability to repress E2F activity through recruitment of a histone deacetylase". Proceedings of the National Academy of Sciences of the United States of America 95 (18): 10493–8. Sep 1998. doi:10.1073/pnas.95.18.10493. PMID 9724731. Bibcode: 1998PNAS...9510493F.
- ↑ "Transforming growth factor-beta1 recruits histone deacetylase 1 to a p130 repressor complex in transgenic mice in vivo". Cancer Research 60 (16): 4531–7. Aug 2000. PMID 10969803.
- ↑ "Prohibitin, a potential tumor suppressor, interacts with RB and regulates E2F function". Oncogene 18 (23): 3501–10. Jun 1999. doi:10.1038/sj.onc.1202684. PMID 10376528.
- ↑ "A mechanism for Rb/p130-mediated transcription repression involving recruitment of the CtBP corepressor". Proceedings of the National Academy of Sciences of the United States of America 96 (17): 9574–9. Aug 1999. doi:10.1073/pnas.96.17.9574. PMID 10449734. Bibcode: 1999PNAS...96.9574M.
- ↑ "Molecular cloning and characterization of a novel retinoblastoma-binding protein". Genomics 51 (3): 351–8. Aug 1998. doi:10.1006/geno.1998.5368. PMID 9721205.
Further reading
- "Rb2/p130 and protein phosphatase 2A: key mediators of ovarian carcinoma cell growth suppression by all-trans retinoic acid". Oncogene 25 (38): 5315–25. Aug 2006. doi:10.1038/sj.onc.1209679. PMID 16936753.
- "pRb2/p130: a new candidate for retinoblastoma tumor formation". Oncogene 25 (38): 5333–40. Aug 2006. doi:10.1038/sj.onc.1209614. PMID 16936755.
- "E2F-5, a new E2F family member that interacts with p130 in vivo". Molecular and Cellular Biology 15 (6): 3082–9. Jun 1995. doi:10.1128/mcb.15.6.3082. PMID 7760804.
- "E2F-4 and E2F-5, two members of the E2F family, are expressed in the early phases of the cell cycle". Proceedings of the National Academy of Sciences of the United States of America 92 (6): 2403–7. Mar 1995. doi:10.1073/pnas.92.6.2403. PMID 7892279. Bibcode: 1995PNAS...92.2403S.
- "The retinoblastoma-related gene, RB2, maps to human chromosome 16q12 and rat chromosome 19". Oncogene 8 (12): 3465–8. Dec 1993. PMID 8247552.
- "The adenovirus E1A-associated 130-kD protein is encoded by a member of the retinoblastoma gene family and physically interacts with cyclins A and E". Genes & Development 7 (12A): 2366–77. Dec 1993. doi:10.1101/gad.7.12a.2366. PMID 8253383.
- "Isolation of the Rb-related p130 through its interaction with CDK2 and cyclins". Genes & Development 7 (12A): 2378–91. Dec 1993. doi:10.1101/gad.7.12a.2378. PMID 8253384.
- "The HMG-box transcription factor HBP1 is targeted by the pocket proteins and E1A". Oncogene 14 (22): 2721–8. Jun 1997. doi:10.1038/sj.onc.1201243. PMID 9178770.
- "Identification of a p130 domain mediating interactions with cyclin A/cdk 2 and cyclin E/cdk 2 complexes". Oncogene 14 (20): 2395–406. May 1997. doi:10.1038/sj.onc.1201085. PMID 9188854.
- "Rb interacts with TAF(II)250/TFIID through multiple domains". Oncogene 15 (4): 385–92. Jul 1997. doi:10.1038/sj.onc.1201204. PMID 9242374.
- "Negative regulation of DNA replication by the retinoblastoma protein is mediated by its association with MCM7". Molecular and Cellular Biology 18 (5): 2748–57. May 1998. doi:10.1128/mcb.18.5.2748. PMID 9566894.
- "A retinoblastoma-binding protein that affects cell-cycle control and confers transforming ability". Nature Genetics 19 (4): 371–4. Aug 1998. doi:10.1038/1258. PMID 9697699.
- "A cellular repressor of E1A-stimulated genes that inhibits activation by E2F". Molecular and Cellular Biology 18 (9): 5032–41. Sep 1998. doi:10.1128/mcb.18.9.5032. PMID 9710587.
- "Molecular cloning and characterization of a novel retinoblastoma-binding protein". Genomics 51 (3): 351–8. Aug 1998. doi:10.1006/geno.1998.5368. PMID 9721205.
- "The three members of the pocket proteins family share the ability to repress E2F activity through recruitment of a histone deacetylase". Proceedings of the National Academy of Sciences of the United States of America 95 (18): 10493–8. Sep 1998. doi:10.1073/pnas.95.18.10493. PMID 9724731. Bibcode: 1998PNAS...9510493F.
- "Differential expression and functionally co-operative roles for the retinoblastoma family of proteins in epidermal differentiation". Oncogene 17 (8): 949–57. Aug 1998. doi:10.1038/sj.onc.1202031. PMID 9747874.
- "Raf-1 physically interacts with Rb and regulates its function: a link between mitogenic signaling and cell cycle regulation". Molecular and Cellular Biology 18 (12): 7487–98. Dec 1998. doi:10.1128/mcb.18.12.7487. PMID 9819434.
- "Functions of cyclin A1 in the cell cycle and its interactions with transcription factor E2F-1 and the Rb family of proteins". Molecular and Cellular Biology 19 (3): 2400–7. Mar 1999. doi:10.1128/mcb.19.3.2400. PMID 10022926.
External links
- RBL2+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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