Biology:PHF21A
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Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
PHD finger protein 21A is a protein that in humans is encoded by the PHF21A gene.[1][2][3]
Function
BHC80 is a component of a BRAF35 (MIM 605535)/histone deacetylase (HDAC; see MIM 601241) complex (BHC) that mediates repression of neuron-specific genes through the cis-regulatory element known as repressor element-1 (RE1) or neural restrictive silencer (NRS) (Hakimi et al., 2002).[supplied by OMIM][3]
Interactions
PHF21A has been shown to interact with:
References
- ↑ "Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (6): 347–55. 2000. doi:10.1093/dnares/7.6.347. PMID 11214970.
- ↑ 2.0 2.1 2.2 2.3 2.4 "A core-BRAF35 complex containing histone deacetylase mediates repression of neuronal-specific genes". Proc. Natl. Acad. Sci. U.S.A. 99 (11): 7420–5. May 2002. doi:10.1073/pnas.112008599. PMID 12032298. Bibcode: 2002PNAS...99.7420H.
- ↑ 3.0 3.1 "Entrez Gene: PHF21A PHD finger protein 21A". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51317.
- ↑ 4.0 4.1 4.2 4.3 "Characterization of BHC80 in BRAF-HDAC complex, involved in neuron-specific gene repression". Biochem. Biophys. Res. Commun. 322 (2): 601–8. Sep 2004. doi:10.1016/j.bbrc.2004.07.163. PMID 15325272.
- ↑ "A candidate X-linked mental retardation gene is a component of a new family of histone deacetylase-containing complexes". J. Biol. Chem. 278 (9): 7234–9. Feb 2003. doi:10.1074/jbc.M208992200. PMID 12493763.
Further reading
- "Regulation of LSD1 histone demethylase activity by its associated factors". Mol. Cell 19 (6): 857–64. 2005. doi:10.1016/j.molcel.2005.08.027. PMID 16140033.
- "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. 2005. doi:10.1038/nature04209. PMID 16189514. Bibcode: 2005Natur.437.1173R.
- "Gene function in early mouse embryonic stem cell differentiation". BMC Genomics 8: 85. 2007. doi:10.1186/1471-2164-8-85. PMID 17394647.
External links
- PHF21A+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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