Biology:PHF21A

From HandWiki
Short description: Protein-coding gene in the species Homo sapiens


A representation of the 3D structure of the protein myoglobin showing turquoise α-helices.
Generic protein structure example

PHD finger protein 21A is a protein that in humans is encoded by the PHF21A gene.[1][2][3]

Function

BHC80 is a component of a BRAF35 (MIM 605535)/histone deacetylase (HDAC; see MIM 601241) complex (BHC) that mediates repression of neuron-specific genes through the cis-regulatory element known as repressor element-1 (RE1) or neural restrictive silencer (NRS) (Hakimi et al., 2002).[supplied by OMIM][3]

Interactions

PHF21A has been shown to interact with:

References

  1. "Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (6): 347–55. 2000. doi:10.1093/dnares/7.6.347. PMID 11214970. 
  2. 2.0 2.1 2.2 2.3 2.4 "A core-BRAF35 complex containing histone deacetylase mediates repression of neuronal-specific genes". Proc. Natl. Acad. Sci. U.S.A. 99 (11): 7420–5. May 2002. doi:10.1073/pnas.112008599. PMID 12032298. Bibcode2002PNAS...99.7420H. 
  3. 3.0 3.1 "Entrez Gene: PHF21A PHD finger protein 21A". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51317. 
  4. 4.0 4.1 4.2 4.3 "Characterization of BHC80 in BRAF-HDAC complex, involved in neuron-specific gene repression". Biochem. Biophys. Res. Commun. 322 (2): 601–8. Sep 2004. doi:10.1016/j.bbrc.2004.07.163. PMID 15325272. 
  5. "A candidate X-linked mental retardation gene is a component of a new family of histone deacetylase-containing complexes". J. Biol. Chem. 278 (9): 7234–9. Feb 2003. doi:10.1074/jbc.M208992200. PMID 12493763. 

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.