Biology:RFX4
 Generic protein structure example |
Transcription factor RFX4 is a protein that in humans is encoded by the RFX4 gene.[1][2][3]
This gene is a member of the regulatory factor X gene family, which encodes transcription factors that contain a highly conserved winged helix DNA binding domain. The protein encoded by this gene is structurally related to regulatory factors X1, X2, X3, and X5. It has been shown to interact with itself as well as with regulatory factors X2 and X3, but it does not interact with regulatory factor X1. This protein may be a transcriptional repressor rather than a transcriptional activator. Three transcript variants encoding different isoforms have been described for this gene.[3]
References
- ↑ "RFX proteins, a novel family of DNA binding proteins conserved in the eukaryotic kingdom". Nucleic Acids Res 24 (5): 803–7. May 1996. doi:10.1093/nar/24.5.803. PMID 8600444.
- ↑ "Human regulatory factor X 4 (RFX4) is a testis-specific dimeric DNA-binding protein that cooperates with other human RFX members". J Biol Chem 277 (1): 836–42. Jan 2002. doi:10.1074/jbc.M108638200. PMID 11682486.
- ↑ 3.0 3.1 "Entrez Gene: RFX4 regulatory factor X, 4 (influences HLA class II expression)". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5992.
Further reading
- "Characterization of estrogen receptor variant mRNAs from human breast cancers". Mol. Endocrinol. 6 (5): 773–85. 1992. doi:10.1210/mend.6.5.1603086. PMID 1603086.
- Reith W; Ucla C; Barras E et al. (1994). "RFX1, a transactivator of hepatitis B virus enhancer I, belongs to a novel family of homodimeric and heterodimeric DNA-binding proteins". Mol. Cell. Biol. 14 (2): 1230–44. doi:10.1128/mcb.14.2.1230. PMID 8289803.
- Gajiwala KS; Chen H; Cornille F et al. (2000). "Structure of the winged-helix protein hRFX1 reveals a new mode of DNA binding". Nature 403 (6772): 916–21. doi:10.1038/35002634. PMID 10706293. Bibcode: 2000Natur.403..916G.
- Strausberg RL; Feingold EA; Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- Blackshear PJ; Graves JP; Stumpo DJ et al. (2003). "Graded phenotypic response to partial and complete deficiency of a brain-specific transcript variant of the winged helix transcription factor RFX4". Development 130 (19): 4539–52. doi:10.1242/dev.00661. PMID 12925582.
- Araki R; Takahashi H; Fukumura R et al. (2004). "Restricted expression and photic induction of a novel mouse regulatory factor X4 transcript in the suprachiasmatic nucleus". J. Biol. Chem. 279 (11): 10237–42. doi:10.1074/jbc.M312761200. PMID 14701801.
- Glaser B; Kirov G; Bray NJ et al. (2005). "Identification of a potential bipolar risk haplotype in the gene encoding the winged-helix transcription factor RFX4". Mol. Psychiatry 10 (10): 920–7. doi:10.1038/sj.mp.4001689. PMID 15940297.
- Rual JF; Venkatesan K; Hao T et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. Bibcode: 2005Natur.437.1173R.
- Matsushita H; Uenaka A; Ono T et al. (2006). "Identification of glioma-specific RFX4-E and -F isoforms and humoral immune response in patients". Cancer Sci. 96 (11): 801–9. doi:10.1111/j.1349-7006.2005.00112.x. PMID 16271074. http://ousar.lib.okayama-u.ac.jp/files/public/1/10679/20160527184719322608/O004152.pdf.
External links
- RFX4+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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