Biology:RFX4

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Short description: Protein-coding gene in the species Homo sapiens


A representation of the 3D structure of the protein myoglobin showing turquoise α-helices.
Generic protein structure example

Transcription factor RFX4 is a protein that in humans is encoded by the RFX4 gene.[1][2][3]

This gene is a member of the regulatory factor X gene family, which encodes transcription factors that contain a highly conserved winged helix DNA binding domain. The protein encoded by this gene is structurally related to regulatory factors X1, X2, X3, and X5. It has been shown to interact with itself as well as with regulatory factors X2 and X3, but it does not interact with regulatory factor X1. This protein may be a transcriptional repressor rather than a transcriptional activator. Three transcript variants encoding different isoforms have been described for this gene.[3]

References

  1. "RFX proteins, a novel family of DNA binding proteins conserved in the eukaryotic kingdom". Nucleic Acids Res 24 (5): 803–7. May 1996. doi:10.1093/nar/24.5.803. PMID 8600444. 
  2. "Human regulatory factor X 4 (RFX4) is a testis-specific dimeric DNA-binding protein that cooperates with other human RFX members". J Biol Chem 277 (1): 836–42. Jan 2002. doi:10.1074/jbc.M108638200. PMID 11682486. 
  3. 3.0 3.1 "Entrez Gene: RFX4 regulatory factor X, 4 (influences HLA class II expression)". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5992. 

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.