Biology:HOXA11

Short description: Protein-coding gene in the species Homo sapiens

Generic protein structure example

Homeobox protein Hox-A11 is a protein that in humans is encoded by the HOXA11 gene.

Function

In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. This gene is involved in the regulation of uterine development and is required for female fertility. Mutations in this gene can cause radioulnar synostosis with amegakaryocytic thrombocytopenia.

See also

• Homeobox

Further reading

• "Implantation in the human: the role of HOX genes". Seminars in Reproductive Medicine 18 (3): 311–20. 2001. doi:10.1055/s-2000-12568. PMID 11299969. 
• "Molecular markers of implantation: clinical implications". Current Opinion in Obstetrics and Gynecology 13 (3): 269–74. Jun 2001. doi:10.1097/00001703-200106000-00004. PMID 11396649. 
• "Genes and proteins in renal development". Experimental Nephrology 10 (2): 102–13. 2002. doi:10.1159/000049905. PMID 11937757. 
• "The role of HOX genes in human implantation". Annals of the New York Academy of Sciences 1034 (1): 1–18. Dec 2004. doi:10.1196/annals.1335.001. PMID 15731295. Bibcode: 2004NYASA1034....1E. 
• "The human HOX gene family". Nucleic Acids Research 17 (24): 10385–402. Dec 1989. doi:10.1093/nar/17.24.10385. PMID 2574852. 
• "Restricted expression of homeobox genes distinguishes fetal from adult human smooth muscle cells". Proceedings of the National Academy of Sciences of the United States of America 93 (2): 900–5. Jan 1996. doi:10.1073/pnas.93.2.900. PMID 8570656. Bibcode: 1996PNAS...93..900M. 
• "Fine mapping of human HOX gene clusters". Cytogenetics and Cell Genetics 73 (1–2): 114–5. 1996. doi:10.1159/000134320. PMID 8646877. 
• "Evolutionary conservation and tissue-specific processing of Hoxa 11 antisense transcripts". Mammalian Genome 9 (10): 799–806. Oct 1998. doi:10.1007/s003359900870. PMID 9745033. 
• "Sex steroids mediate HOXA11 expression in the human peri-implantation endometrium". The Journal of Clinical Endocrinology and Metabolism 84 (3): 1129–35. Mar 1999. doi:10.1210/jcem.84.3.5573. PMID 10084606. 
• "Amegakaryocytic thrombocytopenia and radio-ulnar synostosis are associated with HOXA11 mutation". Nature Genetics 26 (4): 397–8. Dec 2000. doi:10.1038/82511. PMID 11101832. 
• "The HOX homeodomain proteins block CBP histone acetyltransferase activity". Molecular and Cellular Biology 21 (21): 7509–22. Nov 2001. doi:10.1128/MCB.21.21.7509-7522.2001. PMID 11585930. 
• "Single-translocation and double-chimeric transcripts: detection of NUP98-HOXA9 in myeloid leukemias with HOXA11 or HOXA13 breaks of the chromosomal translocation t(7;11)(p15;p15)". Blood 99 (4): 1428–33. Feb 2002. doi:10.1182/blood.V99.4.1428. PMID 11830496. 
• "Absence of mutations in the HoxA10, HoxA11 and HoxD11 nucleotide coding sequences in thrombocytopenia with absent radius syndrome". British Journal of Haematology 116 (2): 367–75. Feb 2002. doi:10.1046/j.1365-2141.2002.03263.x. PMID 11841440. 
• "Complete mutation analysis panel of the 39 human HOX genes". Teratology 65 (2): 50–62. Feb 2002. doi:10.1002/tera.10009. PMID 11857506. 
• "HOXA11 silencing and endogenous HOXA11 antisense ribonucleic acid in the uterine endometrium". The Journal of Clinical Endocrinology and Metabolism 87 (6): 2674–80. Jun 2002. doi:10.1210/jcem.87.6.8527. PMID 12050232. 

External links

• HOXA11+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.