Biology:MXD4
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Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Max-interacting transcriptional repressor MAD4 is a protein that in humans is encoded by the MXD4 gene.[1][2]
Function
This gene is a member of the MAD gene family . The MAD genes encode basic helix-loop-helix-leucine zipper proteins that heterodimerize with MAX protein, forming a transcriptional repression complex. The MAD proteins compete for MAX binding with MYC, which heterodimerizes with MAX forming a transcriptional activation complex. Studies in rodents suggest that the MAD genes are tumor suppressors and contribute to the regulation of cell growth in differentiating tissues.[2]
References
- ↑ "Mad3 and Mad4: novel Max-interacting transcriptional repressors that suppress c-myc dependent transformation and are expressed during neural and epidermal differentiation". The EMBO Journal 14 (22): 5646–59. November 1995. doi:10.1002/j.1460-2075.1995.tb00252.x. PMID 8521822.
- ↑ 2.0 2.1 "Entrez Gene: MXD4 MAX dimerization protein 4". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10608.
Further reading
- "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. October 2005. doi:10.1038/nature04209. PMID 16189514. Bibcode: 2005Natur.437.1173R.
- "c-Myc creates an activation loop by transcriptionally repressing its own functional inhibitor, hMad4, in young fibroblasts, a loop lost in replicatively senescent fibroblasts". Journal of Cellular Biochemistry 96 (5): 1071–85. December 2005. doi:10.1002/jcb.20503. PMID 16167342.
- "Yeast two-hybrid identification of prostatic proteins interacting with human sex hormone-binding globulin". The Journal of Steroid Biochemistry and Molecular Biology 94 (1–3): 203–8. February 2005. doi:10.1016/j.jsbmb.2005.01.007. PMID 15862967.
- "Human liver specific transcriptional factor TCP10L binds to MAD4". Journal of Biochemistry and Molecular Biology 37 (4): 402–7. July 2004. doi:10.5483/bmbrep.2004.37.4.402. PMID 15469726.
- "Mad4 is regulated by a transcriptional repressor complex that contains Miz-1 and c-Myc". The Biochemical Journal 370 (Pt 1): 291–8. February 2003. doi:10.1042/BJ20021679. PMID 12418961.
- "WBSCR14, a gene mapping to the Williams--Beuren syndrome deleted region, is a new member of the Mlx transcription factor network". Human Molecular Genetics 10 (6): 617–27. March 2001. doi:10.1093/hmg/10.6.617. PMID 11230181.
- "Mlx, a novel Max-like BHLHZip protein that interacts with the Max network of transcription factors". The Journal of Biological Chemistry 274 (51): 36344–50. December 1999. doi:10.1074/jbc.274.51.36344. PMID 10593926.
External links
- MXD4+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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