Biology:E2F2
 Generic protein structure example |
Transcription factor E2F2 is a protein that in humans is encoded by the E2F2 gene.[1][2]
Function
The protein encoded by this gene is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F1 and E2F3, have an additional cyclin binding domain. This protein binds specifically to retinoblastoma protein pRB in a cell-cycle dependent manner, and it exhibits overall 46% amino acid identity to E2F1.[3]
Interactions
E2F2 has been shown to interact with:
See also
References
- ↑ "Cloning and characterization of E2F-2, a novel protein with the biochemical properties of transcription factor E2F". Mol Cell Biol 13 (12): 7802–12. January 1994. doi:10.1128/MCB.13.12.7802. PMID 8246995.
- ↑ "The retinoblastoma protein binds to a family of E2F transcription factors". Mol Cell Biol 13 (12): 7813–25. January 1994. doi:10.1128/mcb.13.12.7813. PMID 8246996.
- ↑ "Entrez Gene: E2F2 E2F transcription factor 2". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1870.
- ↑ "Reproductive cycle regulation of nuclear import, euchromatic localization, and association with components of Pol II mediator of a mammalian double-bromodomain protein". Mol. Endocrinol. 16 (8): 1727–37. August 2002. doi:10.1210/me.2001-0353. PMID 12145330.
- ↑ "RING3 kinase transactivates promoters of cell cycle regulatory genes through E2F". Cell Growth Differ. 11 (8): 417–24. August 2000. PMID 10965846.
- ↑ "Interaction of YY1 with E2Fs, mediated by RYBP, provides a mechanism for specificity of E2F function". EMBO J. 21 (21): 5775–86. November 2002. doi:10.1093/emboj/cdf577. PMID 12411495.
- ↑ "Structural basis for the recognition of the E2F transactivation domain by the retinoblastoma tumor suppressor". Genes Dev. 16 (24): 3199–212. December 2002. doi:10.1101/gad.1046102. PMID 12502741.
Further reading
- "The regulation of E2F by pRB-family proteins.". Genes Dev. 12 (15): 2245–62. 1998. doi:10.1101/gad.12.15.2245. PMID 9694791.
- "In vivo association of E2F and DP family proteins". Mol. Cell. Biol. 15 (5): 2536–46. 1995. doi:10.1128/mcb.15.5.2536. PMID 7739537.
- "Interaction of Sp1 with the growth- and cell cycle-regulated transcription factor E2F". Mol. Cell. Biol. 16 (4): 1659–67. 1996. doi:10.1128/mcb.16.4.1659. PMID 8657141.
- "Cell cycle-regulated association of E2F1 and Sp1 is related to their functional interaction". Mol. Cell. Biol. 16 (4): 1668–75. 1996. doi:10.1128/MCB.16.4.1668. PMID 8657142.
- "DP-2, a heterodimeric partner of E2F: identification and characterization of DP-2 proteins expressed in vivo". Proc. Natl. Acad. Sci. U.S.A. 93 (15): 7594–9. 1996. doi:10.1073/pnas.93.15.7594. PMID 8755520. Bibcode: 1996PNAS...93.7594R.
- "Nuclear localization of DP and E2F transcription factors by heterodimeric partners and retinoblastoma protein family members". J. Cell Sci. 109 (7): 1717–26. 1997. doi:10.1242/jcs.109.7.1717. PMID 8832394.
- "Differential effects of cdk2 and cdk3 on the control of pRb and E2F function during G1 exit". Genes Dev. 10 (7): 851–61. 1996. doi:10.1101/gad.10.7.851. PMID 8846921.
- "The subcellular localization of E2F-4 is cell-cycle dependent". Proc. Natl. Acad. Sci. U.S.A. 94 (10): 5095–100. 1997. doi:10.1073/pnas.94.10.5095. PMID 9144196. Bibcode: 1997PNAS...94.5095L.
- "Differential activities of E2F family members: unique functions in regulating transcription". Mol. Carcinog. 22 (3): 190–8. 1998. doi:10.1002/(SICI)1098-2744(199807)22:3<190::AID-MC7>3.0.CO;2-P. PMID 9688145.
- "Deregulated E2F transcriptional activity in autonomously growing melanoma cells". J. Exp. Med. 191 (6): 1005–16. 2000. doi:10.1084/jem.191.6.1005. PMID 10727462.
- "Analysis of promoter binding by the E2F and pRB families in vivo: distinct E2F proteins mediate activation and repression". Genes Dev. 14 (7): 804–16. 2000. doi:10.1101/gad.14.7.804. PMID 10766737.
- "RING3 kinase transactivates promoters of cell cycle regulatory genes through E2F". Cell Growth Differ. 11 (8): 417–24. 2001. PMID 10965846.
- "The E2F1-3 transcription factors are essential for cellular proliferation". Nature 414 (6862): 457–62. 2001. doi:10.1038/35106593. PMID 11719808. Bibcode: 2001Natur.414..457W.
- "ik3-1/Cables is a substrate for cyclin-dependent kinase 3 (cdk 3)". Eur. J. Biochem. 268 (23): 6076–82. 2002. doi:10.1046/j.0014-2956.2001.02555.x. PMID 11733001.
- "Isolating human transcription factor targets by coupling chromatin immunoprecipitation and CpG island microarray analysis". Genes Dev. 16 (2): 235–44. 2002. doi:10.1101/gad.943102. PMID 11799066.
- "Reproductive cycle regulation of nuclear import, euchromatic localization, and association with components of Pol II mediator of a mammalian double-bromodomain protein". Mol. Endocrinol. 16 (8): 1727–37. 2003. doi:10.1210/me.2001-0353. PMID 12145330.
- "Interaction of YY1 with E2Fs, mediated by RYBP, provides a mechanism for specificity of E2F function". EMBO J. 21 (21): 5775–86. 2002. doi:10.1093/emboj/cdf577. PMID 12411495.
External links
- E2F2+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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