Biology:Liver receptor homolog-1
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Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
The liver receptor homolog-1 (LRH-1) also known as totipotency pioneer factor NR5A2 (nuclear receptor subfamily 5, group A, member 2) is a protein that in humans is encoded by the NR5A2 gene.[1][2] LRH-1 is a member of the nuclear receptor family of intracellular transcription factors.
LRH-1 plays a critical role in the regulation of development, cholesterol transport, bile acid homeostasis and steroidogenesis.[3][4][5][6]
LRH-1 is important for maintaining pluripotence of stem cells during embryonic development.[7][6]
Interactions
Liver receptor homolog-1 has been shown to interact with the small heterodimer partner.[8][9]
References
- ↑ "Functional analysis of developmentally regulated chromatin-hypersensitive domains carrying the alpha 1-fetoprotein gene promoter and the albumin/alpha 1-fetoprotein intergenic enhancer". Molecular and Cellular Biology 13 (3): 1619–33. Mar 1993. doi:10.1128/mcb.13.3.1619. PMID 7680097.
- ↑ "Assignment of the fetoprotein transcription factor gene (FTF) to human chromosome band 1q32.11 by in situ hybridization". Cytogenetics and Cell Genetics 82 (3–4): 269–70. 1998. doi:10.1159/000015116. PMID 9858833.
- ↑ "LRH-1: an orphan nuclear receptor involved in development, metabolism and steroidogenesis". Trends in Cell Biology 14 (5): 250–60. May 2004. doi:10.1016/j.tcb.2004.03.008. PMID 15130581.
- ↑ "The orphan nuclear receptor LRH-1 potentiates the sterol-mediated induction of the human CETP gene by liver X receptor". The Journal of Biological Chemistry 276 (27): 24767–73. Jul 2001. doi:10.1074/jbc.M100912200. PMID 11331284.
- ↑ "CPF: an orphan nuclear receptor that regulates liver-specific expression of the human cholesterol 7alpha-hydroxylase gene". Proceedings of the National Academy of Sciences of the United States of America 96 (12): 6660–5. Jun 1999. doi:10.1073/pnas.96.12.6660. PMID 10359768. Bibcode: 1999PNAS...96.6660N.
- ↑ 6.0 6.1 "Zygotic genome activation by the totipotency pioneer factor Nr5a2". Science 378 (6626): 1305–1315. Nov 2022. doi:10.1126/science.abn7478. PMID 36423263. Bibcode: 2022Sci...378.1305G. https://www.science.org/doi/10.1126/science.abn7478?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmed.
- ↑ "Orphan nuclear receptor LRH-1 is required to maintain Oct4 expression at the epiblast stage of embryonic development". Molecular and Cellular Biology 25 (9): 3492–505. May 2005. doi:10.1128/MCB.25.9.3492-3505.2005. PMID 15831456.
- ↑ "The small heterodimer partner interacts with the liver X receptor alpha and represses its transcriptional activity". Molecular Endocrinology 16 (9): 2065–76. Sep 2002. doi:10.1210/me.2001-0194. PMID 12198243.
- ↑ "Dual mechanisms for repression of the monomeric orphan receptor liver receptor homologous protein-1 by the orphan small heterodimer partner". The Journal of Biological Chemistry 277 (4): 2463–7. Jan 2002. doi:10.1074/jbc.M105161200. PMID 11668176.
Further reading
- "Cloning and sequence analysis of the human gene encoding steroidogenic factor 1". Journal of Molecular Endocrinology 17 (2): 139–47. Oct 1996. doi:10.1677/jme.0.0170139. PMID 8938589.
- "Cloning and characterization of a novel human hepatocyte transcription factor, hB1F, which binds and activates enhancer II of hepatitis B virus". The Journal of Biological Chemistry 273 (44): 29022–31. Oct 1998. doi:10.1074/jbc.273.44.29022. PMID 9786908.
- "CPF: an orphan nuclear receptor that regulates liver-specific expression of the human cholesterol 7alpha-hydroxylase gene". Proceedings of the National Academy of Sciences of the United States of America 96 (12): 6660–5. Jun 1999. doi:10.1073/pnas.96.12.6660. PMID 10359768. Bibcode: 1999PNAS...96.6660N.
- "A regulatory cascade of the nuclear receptors FXR, SHP-1, and LRH-1 represses bile acid biosynthesis". Molecular Cell 6 (3): 517–26. Sep 2000. doi:10.1016/S1097-2765(00)00051-4. PMID 11030332.
- "Liver receptor homologue-1 is expressed in the adrenal and can regulate transcription of 11 beta-hydroxylase". Journal of Molecular Endocrinology 27 (2): 255–8. Oct 2001. doi:10.1677/jme.0.0270255. PMID 11564608.
- "Characterization of the genomic structure and tissue-specific promoter of the human nuclear receptor NR5A2 (hB1F) gene". Gene 273 (2): 239–49. Aug 2001. doi:10.1016/S0378-1119(01)00586-8. PMID 11595170.
- "Dual mechanisms for repression of the monomeric orphan receptor liver receptor homologous protein-1 by the orphan small heterodimer partner". The Journal of Biological Chemistry 277 (4): 2463–7. Jan 2002. doi:10.1074/jbc.M105161200. PMID 11668176.
- "Liver receptor homologue-1 (LRH-1) regulates expression of aromatase in preadipocytes". The Journal of Biological Chemistry 277 (23): 20591–7. Jun 2002. doi:10.1074/jbc.M201117200. PMID 11927588.
- "Multiprotein bridging factor-1 (MBF-1) is a cofactor for nuclear receptors that regulate lipid metabolism". Molecular Endocrinology 16 (6): 1367–77. Jun 2002. doi:10.1210/mend.16.6.0843. PMID 12040021.
- "Liver receptor homologue-1 is expressed in human steroidogenic tissues and activates transcription of genes encoding steroidogenic enzymes". The Journal of Endocrinology 174 (3): R13–7. Sep 2002. doi:10.1677/joe.0.174R013. PMID 12208674.
- "Structural basis for ligand-independent activation of the orphan nuclear receptor LRH-1". Molecular Cell 11 (6): 1575–85. Jun 2003. doi:10.1016/S1097-2765(03)00236-3. PMID 12820970.
- "Activation incarnate". Developmental Cell 5 (1): 1–2. Jul 2003. doi:10.1016/S1534-5807(03)00196-5. PMID 12852843.
- "Liver receptor homolog 1 controls the expression of carboxyl ester lipase". The Journal of Biological Chemistry 278 (37): 35725–31. Sep 2003. doi:10.1074/jbc.M302370200. PMID 12853459.
- "Pancreatic-duodenal homeobox 1 regulates expression of liver receptor homolog 1 during pancreas development". Molecular and Cellular Biology 23 (19): 6713–24. Oct 2003. doi:10.1128/MCB.23.19.6713-6724.2003. PMID 12972592.
- "The role of the orphan nuclear receptor, liver receptor homologue-1, in the regulation of human corpus luteum 3beta-hydroxysteroid dehydrogenase type II". The Journal of Clinical Endocrinology and Metabolism 88 (12): 6020–8. Dec 2003. doi:10.1210/jc.2003-030880. PMID 14671206.
- "LRH-1/hB1F and HNF1 synergistically up-regulate hepatitis B virus gene transcription and DNA replication". Cell Research 13 (6): 451–8. Dec 2003. doi:10.1038/sj.cr.7290187. PMID 14728801.
- "Liver receptor homolog-1 stimulates the progesterone biosynthetic pathway during follicle-stimulating hormone-induced granulosa cell differentiation". Endocrinology 145 (8): 3821–9. Aug 2004. doi:10.1210/en.2004-0423. PMID 15117876.
External links
- NR5A2+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
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