Biology:IKZF3
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Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Zinc finger protein Aiolos also known as Ikaros family zinc finger protein 3 is a protein that in humans is encoded by the IKZF3 gene.[1][2][3]
Function
This gene encodes a member of the Ikaros family of zinc-finger proteins. Three members of this protein family (Ikaros, Aiolos and Helios) are hematopoietic-specific transcription factors involved in the regulation of lymphocyte development. This gene product is a transcription factor that is important in the regulation of B lymphocyte proliferation and differentiation. Both Ikaros and Aiolos can participate in chromatin remodeling. Regulation of gene expression in B lymphocytes by Aiolos is complex as it appears to require the sequential formation of Ikaros homodimers, Ikaros/Aiolos heterodimers, and Aiolos homodimers. At least six alternative transcripts encoding different isoforms have been described.[3]
Interactions
IKZF3 has been shown to interact with BCL2-like 1[4] and HRAS.[5]
References
- ↑ "Aiolos, a lymphoid restricted transcription factor that interacts with Ikaros to regulate lymphocyte differentiation". The EMBO Journal 16 (8): 2004–13. April 1997. doi:10.1093/emboj/16.8.2004. PMID 9155026.
- ↑ "Human aiolos, an ikaros-related zinc finger DNA binding protein: cDNA cloning, tissue expression pattern, and chromosomal mapping". Genomics 61 (3): 326–9. November 1999. doi:10.1006/geno.1999.5949. PMID 10552935.
- ↑ 3.0 3.1 "Entrez Gene: IKZF3 IKAROS family zinc finger 3 (Aiolos)". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=22806.
- ↑ "The association of Aiolos transcription factor and Bcl-xL is involved in the control of apoptosis". Journal of Immunology 167 (11): 6366–73. December 2001. doi:10.4049/jimmunol.167.11.6366. PMID 11714801.
- ↑ "Aiolos transcription factor controls cell death in T cells by regulating Bcl-2 expression and its cellular localization". The EMBO Journal 18 (12): 3419–30. June 1999. doi:10.1093/emboj/18.12.3419. PMID 10369681.
Further reading
- "Lack of the transcriptional coactivator OBF-1 prevents the development of systemic lupus erythematosus-like phenotypes in Aiolos mutant mice". Journal of Immunology 170 (4): 1699–706. February 2003. doi:10.4049/jimmunol.170.4.1699. PMID 12574333.
- "Aiolos and Ikaros: regulators of lymphocyte development, homeostasis and lymphoproliferation". Apoptosis 7 (3): 277–84. June 2002. doi:10.1023/A:1015372322419. PMID 11997672.
- "Aiolos regulates B cell activation and maturation to effector state". Immunity 9 (4): 543–53. October 1998. doi:10.1016/S1074-7613(00)80637-8. PMID 9806640.
- "Ikaros DNA-binding proteins direct formation of chromatin remodeling complexes in lymphocytes". Immunity 10 (3): 345–55. March 1999. doi:10.1016/S1074-7613(00)80034-5. PMID 10204490.
- "Repression by Ikaros and Aiolos is mediated through histone deacetylase complexes". The EMBO Journal 18 (11): 3090–100. June 1999. doi:10.1093/emboj/18.11.3090. PMID 10357820.
- "Aiolos transcription factor controls cell death in T cells by regulating Bcl-2 expression and its cellular localization". The EMBO Journal 18 (12): 3419–30. June 1999. doi:10.1093/emboj/18.12.3419. PMID 10369681.
- "Ikaros interactions with CtBP reveal a repression mechanism that is independent of histone deacetylase activity". The Journal of Biological Chemistry 275 (26): 19594–602. June 2000. doi:10.1074/jbc.M000254200. PMID 10766745.
- "Eos and pegasus, two members of the Ikaros family of proteins with distinct DNA binding activities". The Journal of Biological Chemistry 275 (49): 38347–54. December 2000. doi:10.1074/jbc.M005457200. PMID 10978333.
- "The association of Aiolos transcription factor and Bcl-xL is involved in the control of apoptosis". Journal of Immunology 167 (11): 6366–73. December 2001. doi:10.4049/jimmunol.167.11.6366. PMID 11714801.
- "Both normal and leukemic B lymphocytes express multiple isoforms of the human Aiolos gene". European Journal of Immunology 31 (12): 3469–74. December 2001. doi:10.1002/1521-4141(200112)31:12<3469::AID-IMMU3469>3.0.CO;2-G. PMID 11745366.
- "Overexpression of novel short isoforms of Helios in a patient with T-cell acute lymphoblastic leukemia". Experimental Hematology 30 (4): 313–7. April 2002. doi:10.1016/S0301-472X(01)00796-2. PMID 11937265.
- "A molecular dissection of the repression circuitry of Ikaros". The Journal of Biological Chemistry 277 (31): 27697–705. August 2002. doi:10.1074/jbc.M201694200. PMID 12015313.
- "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. October 2005. doi:10.1038/nature04209. PMID 16189514. Bibcode: 2005Natur.437.1173R.
- "A search for a mutation of the Aiolos phosphorylation domain in lymphocytes from patients with leukemia". Haematologica 92 (2): 260–1. February 2007. doi:10.3324/haematol.10753. PMID 17296582.
- "Critical function of Ikaros in controlling Aiolos gene expression". FEBS Letters 581 (8): 1605–16. April 2007. doi:10.1016/j.febslet.2007.03.025. PMID 17383641.
- "Combinatorial effects of splice variants modulate function of Aiolos". Journal of Cell Science 120 (Pt 15): 2619–30. August 2007. doi:10.1242/jcs.007344. PMID 17646674.
External links
- IKZF3+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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