Biology:HOXB3
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Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Homeobox protein Hox-B3 is a protein that in humans is encoded by the HOXB3 gene.[1][2][3]
This gene is a member of the Antp homeobox family and encodes a nuclear protein with a homeobox DNA-binding domain. It is included in a cluster of homeobox B genes located on chromosome 17. The encoded protein functions as a sequence-specific transcription factor that is involved in development. Increased expression of this gene is associated with a distinct biologic subset of acute myeloid leukemia (AML).[3]
See also
References
- ↑ "Nomenclature for human homeobox genes". Genomics 7 (3): 460. Aug 1990. doi:10.1016/0888-7543(90)90186-X. PMID 1973146.
- ↑ Scott MP (Dec 1992). "Vertebrate homeobox gene nomenclature". Cell 71 (4): 551–3. doi:10.1016/0092-8674(92)90588-4. PMID 1358459.
- ↑ 3.0 3.1 "Entrez Gene: HOXB3 homeobox B3". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3213.
Further reading
- Giampaolo A; Acampora D; Zappavigna V et al. (1989). "Differential expression of human HOX-2 genes along the anterior-posterior axis in embryonic central nervous system". Differentiation 40 (3): 191–7. doi:10.1111/j.1432-0436.1989.tb00598.x. PMID 2570724.
- Acampora D; D'Esposito M; Faiella A et al. (1990). "The human HOX gene family". Nucleic Acids Res. 17 (24): 10385–402. doi:10.1093/nar/17.24.10385. PMID 2574852.
- Boncinelli E; Acampora D; Pannese M et al. (1990). "Organization of human class I homeobox genes". Genome 31 (2): 745–56. doi:10.1139/g89-133. PMID 2576652.
- Guazzi S; Lonigro R; Pintonello L et al. (1994). "The thyroid transcription factor-1 gene is a candidate target for regulation by Hox proteins". EMBO J. 13 (14): 3339–47. doi:10.1002/j.1460-2075.1994.tb06636.x. PMID 7913891.
- Apiou F; Flagiello D; Cillo C et al. (1996). "Fine mapping of human HOX gene clusters". Cytogenet. Cell Genet. 73 (1–2): 114–5. doi:10.1159/000134320. PMID 8646877.
- "Oct-1 interacts with conserved motifs in the human thyroid transcription factor 1 gene minimal promoter". Biochem. J. 319 ( Pt 3) (Pt 3): 669–74. 1996. doi:10.1042/bj3190669. PMID 8920965.
- Sauvageau G; Thorsteinsdottir U; Hough MR et al. (1997). "Overexpression of HOXB3 in hematopoietic cells causes defective lymphoid development and progressive myeloproliferation". Immunity 6 (1): 13–22. doi:10.1016/S1074-7613(00)80238-1. PMID 9052833.
- "Regulatory interactions between the human HOXB1, HOXB2, and HOXB3 proteins and the upstream sequence of the Otx2 gene in embryonal carcinoma cells". J. Biol. Chem. 273 (18): 11092–9. 1998. doi:10.1074/jbc.273.18.11092. PMID 9556594.
- "Definition of the Transcriptional Activation Domains of Three Human HOX Proteins Depends on the DNA-Binding Context". Mol. Cell. Biol. 18 (11): 6201–12. 1998. doi:10.1128/MCB.18.11.6201. PMID 9774637.
- Kosaki K; Kosaki R; Suzuki T et al. (2002). "Complete mutation analysis panel of the 39 human HOX genes". Teratology 65 (2): 50–62. doi:10.1002/tera.10009. PMID 11857506.
- "Increased gene expression of lung marker proteins in the homeobox B3-overexpressed fetal lung cell line M3E3/C3". Cell Growth Differ. 13 (4): 195–203. 2002. PMID 11971819.
- Ota T; Suzuki Y; Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- "Differential and Common Leukemogenic Potentials of Multiple NUP98-Hox Fusion Proteins Alone or with Meis1". Mol. Cell. Biol. 24 (5): 1907–17. 2004. doi:10.1128/MCB.24.5.1907-1917.2004. PMID 14966272.
- Roche J; Zeng C; Barón A et al. (2004). "Hox expression in AML identifies a distinct subset of patients with intermediate cytogenetics". Leukemia 18 (6): 1059–63. doi:10.1038/sj.leu.2403366. PMID 15085154.
- Brandenberger R; Wei H; Zhang S et al. (2005). "Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation". Nat. Biotechnol. 22 (6): 707–16. doi:10.1038/nbt971. PMID 15146197.
- Speleman F; Cauwelier B; Dastugue N et al. (2005). "A new recurrent inversion, inv(7)(p15q34), leads to transcriptional activation of HOXA10 and HOXA11 in a subset of T-cell acute lymphoblastic leukemias". Leukemia 19 (3): 358–66. doi:10.1038/sj.leu.2403657. PMID 15674412.
- Kimura K; Wakamatsu A; Suzuki Y et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMID 16344560.
External links
- HOXB3+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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