Biology:NFATC3
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Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Nuclear factor of activated T-cells, cytoplasmic 3 is a protein that in humans is encoded by the NFATC3 gene.[1][2]
Function
The product of this gene is a member of the nuclear factors of activated T cells DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor (TCR) stimulation and an inducible nuclear component. Other members of this family participate to form this complex also. The product of this gene plays a role in the regulation of gene expression in T cells and immature thymocytes. Four transcript variants encoding distinct isoforms have been identified for this gene.[2]
See also
References
- ↑ "Isolation of two new members of the NF-AT gene family and functional characterization of the NF-AT proteins". Immunity 2 (5): 461–72. May 1995. doi:10.1016/1074-7613(95)90027-6. PMID 7749981.
- ↑ 2.0 2.1 "Entrez Gene: NFATC3 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4775.
Further reading
- "Transcription factors of the NFAT family: regulation and function". Annual Review of Immunology 15: 707–47. 1997. doi:10.1146/annurev.immunol.15.1.707. PMID 9143705.
- "Generic signals and specific outcomes: signaling through Ca2+, calcineurin, and NF-AT". Cell 96 (5): 611–4. Mar 1999. doi:10.1016/S0092-8674(00)80571-1. PMID 10089876.
- "NFAT: ubiquitous regulator of cell differentiation and adaptation". The Journal of Cell Biology 156 (5): 771–4. Mar 2002. doi:10.1083/jcb.200111073. PMID 11877454.
- "NFATx, a novel member of the nuclear factor of activated T cells family that is expressed predominantly in the thymus". Molecular and Cellular Biology 15 (5): 2697–706. May 1995. doi:10.1128/mcb.15.5.2697. PMID 7739550.
- "Interaction of HIV gp120 and anti-CD4 antibodies with the CD4 molecule on human CD4+ T cells inhibits the binding activity of NF-AT, NF-kappa B and AP-1, three nuclear factors regulating interleukin-2 gene enhancer activity". European Journal of Immunology 24 (11): 2646–52. Nov 1994. doi:10.1002/eji.1830241112. PMID 7957556.
- "Human immunodeficiency virus type-1 tat enhances interleukin-2 promoter activity through synergism with phorbol ester and calcium-mediated activation of the NF-AT cis-regulatory motif". Biochemical and Biophysical Research Communications 205 (1): 467–74. Nov 1994. doi:10.1006/bbrc.1994.2689. PMID 7999066.
- "Cyclosporin A sensitivity of the HIV-1 long terminal repeat identifies distinct p56lck-dependent pathways activated by CD4 triggering". European Journal of Immunology 26 (9): 2181–8. Sep 1996. doi:10.1002/eji.1830260933. PMID 8814265.
- "Control of NFATx1 nuclear translocation by a calcineurin-regulated inhibitory domain". Molecular and Cellular Biology 17 (4): 2066–75. Apr 1997. doi:10.1128/mcb.17.4.2066. PMID 9121455.
- "Nuclear accumulation of NFAT4 opposed by the JNK signal transduction pathway". Science 278 (5343): 1638–41. Nov 1997. doi:10.1126/science.278.5343.1638. PMID 9374467. Bibcode: 1997Sci...278.1638C.
- "Distinct NFAT family proteins are involved in the nuclear NFAT-DNA binding complexes from human thymocyte subsets". Journal of Immunology 160 (5): 2324–33. Mar 1998. doi:10.4049/jimmunol.160.5.2324. PMID 9498773.
- "Intramolecular masking of nuclear import signal on NF-AT4 by casein kinase I and MEKK1". Cell 93 (5): 851–61. May 1998. doi:10.1016/S0092-8674(00)81445-2. PMID 9630228.
- "Selective inhibition of NFAT activation by a peptide spanning the calcineurin targeting site of NFAT". Molecular Cell 1 (5): 627–37. Apr 1998. doi:10.1016/S1097-2765(00)80063-5. PMID 9660947.
- "Carboxyl-terminal 15-amino acid sequence of NFATx1 is possibly created by tissue-specific splicing and is essential for transactivation activity in T cells". Journal of Immunology 161 (7): 3455–63. Oct 1998. doi:10.4049/jimmunol.161.7.3455. PMID 9759864.
- "Genome duplications and other features in 12 Mb of DNA sequence from human chromosome 16p and 16q". Genomics 60 (3): 295–308. Sep 1999. doi:10.1006/geno.1999.5927. PMID 10493829.
- "A constitutively nuclear form of NFATx shows efficient transactivation activity and induces differentiation of CD4(+)CD8(+) T cells". The Journal of Biological Chemistry 277 (28): 25640–8. Jul 2002. doi:10.1074/jbc.M201860200. PMID 11997392. https://authors.library.caltech.edu/3635/1/AMAjbc02.pdf.
- "A missense mutation (R565W) in cirhin (FLJ14728) in North American Indian childhood cirrhosis". American Journal of Human Genetics 71 (6): 1443–9. Dec 2002. doi:10.1086/344580. PMID 12417987.
External links
- NFATC3+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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