Biology:Testicular receptor 4
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Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Testicular receptor 4 also known as NR2C2 (nuclear receptor subfamily 2, group C, member 2) is a protein that in humans is encoded by the NR2C2 gene.[1][2][3]
The testicular receptor 4 is a member of the nuclear receptor family of transcription factors. Though currently considered an orphan receptor, it nevertheless has an important role as a core DNA binding component of the so called DRED complex (direct repeat erythroid determinant). This complex is formed out of TR4, testicular receptor 2, DNMT1, and KDM1A, and functions as a gene repressor the regulates the expression of red blood cell globin. In particular, it contributes to the transition from fetal to adult pattern expression.[4]
Interactions
Testicular receptor 4 has been shown to interact with
See also
References
- ↑ "Entrez Gene: NR2C2". https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=7182.
- ↑ "Human and rat TR4 orphan receptors specify a subclass of the steroid receptor superfamily". Proceedings of the National Academy of Sciences of the United States of America 91 (13): 6040–4. Jun 1994. doi:10.1073/pnas.91.13.6040. PMID 8016112. Bibcode: 1994PNAS...91.6040C.
- ↑ "New variants of the human and rat nuclear hormone receptor, TR4: expression and chromosomal localization of the human gene". Genomics 35 (2): 361–6. Jul 1996. doi:10.1006/geno.1996.0368. PMID 8661150.
- ↑ "Orphan nuclear receptors TR2 and TR4 in erythropoiesis: From mechanisms to therapies". Biomolecules 15 (6). 2025-05-31. doi:10.3390/biom15060798.
- ↑ "Convergence of two repressors through heterodimer formation of androgen receptor and testicular orphan receptor-4: a unique signaling pathway in the steroid receptor superfamily". Proceedings of the National Academy of Sciences of the United States of America 96 (26): 14724–9. Dec 1999. doi:10.1073/pnas.96.26.14724. PMID 10611280. Bibcode: 1999PNAS...9614724L.
- ↑ "Modulation of estrogen receptor-mediated transactivation by orphan receptor TR4 in MCF-7 cells". The Journal of Biological Chemistry 277 (17): 14622–8. Apr 2002. doi:10.1074/jbc.M110051200. PMID 11844790.
- ↑ "Suppression of hepatitis B virus core promoter by the nuclear orphan receptor TR4". The Journal of Biological Chemistry 278 (11): 9353–60. Mar 2003. doi:10.1074/jbc.M205944200. PMID 12522137.
Further reading
- "TAK1: molecular cloning and characterization of a new member of the nuclear receptor superfamily". Molecular Endocrinology 8 (12): 1667–80. Dec 1994. doi:10.1210/mend.8.12.7708055. PMID 7708055. https://zenodo.org/record/1236241.
- "Induction of the intronic enhancer of the human ciliary neurotrophic factor receptor (CNTFRalpha) gene by the TR4 orphan receptor. A member of steroid receptor superfamily". The Journal of Biological Chemistry 272 (5): 3109–16. Jan 1997. doi:10.1074/jbc.272.5.3109. PMID 9006963.
- "A novel nuclear receptor heterodimerization pathway mediated by orphan receptors TR2 and TR4". The Journal of Biological Chemistry 273 (39): 25209–15. Sep 1998. doi:10.1074/jbc.273.39.25209. PMID 9737983.
- "Convergence of two repressors through heterodimer formation of androgen receptor and testicular orphan receptor-4: a unique signaling pathway in the steroid receptor superfamily". Proceedings of the National Academy of Sciences of the United States of America 96 (26): 14724–9. Dec 1999. doi:10.1073/pnas.96.26.14724. PMID 10611280. Bibcode: 1999PNAS...9614724L.
- "Identification and characterization of a novel androgen receptor coregulator ARA267-alpha in prostate cancer cells". The Journal of Biological Chemistry 276 (44): 40417–23. Nov 2001. doi:10.1074/jbc.M104765200. PMID 11509567.
- "Raf kinase inhibitor protein interacts with NF-kappaB-inducing kinase and TAK1 and inhibits NF-kappaB activation". Molecular and Cellular Biology 21 (21): 7207–17. Nov 2001. doi:10.1128/MCB.21.21.7207-7217.2001. PMID 11585904.
- "Modulation of estrogen receptor-mediated transactivation by orphan receptor TR4 in MCF-7 cells". The Journal of Biological Chemistry 277 (17): 14622–8. Apr 2002. doi:10.1074/jbc.M110051200. PMID 11844790.
- "An embryonic/fetal beta-type globin gene repressor contains a nuclear receptor TR2/TR4 heterodimer". The EMBO Journal 21 (13): 3434–42. Jul 2002. doi:10.1093/emboj/cdf340. PMID 12093744.
- "Identification of a novel testicular orphan receptor-4 (TR4)-associated protein as repressor for the selective suppression of TR4-mediated transactivation". The Journal of Biological Chemistry 278 (9): 7709–17. Feb 2003. doi:10.1074/jbc.M207116200. PMID 12486131.
- "Suppression of hepatitis B virus core promoter by the nuclear orphan receptor TR4". The Journal of Biological Chemistry 278 (11): 9353–60. Mar 2003. doi:10.1074/jbc.M205944200. PMID 12522137.
- "TAK1 is critical for IkappaB kinase-mediated activation of the NF-kappaB pathway". Journal of Molecular Biology 326 (1): 105–15. Feb 2003. doi:10.1016/S0022-2836(02)01404-3. PMID 12547194.
- "Differential and bi-directional regulation between TR2/TR4 orphan nuclear receptors and a specific ligand mediated-peroxisome proliferator-activated receptor alpha in human HaCaT keratinocytes". Journal of Dermatological Science 31 (1): 65–71. Feb 2003. doi:10.1016/S0923-1811(02)00152-4. PMID 12615366.
- "Role of the TAB2-related protein TAB3 in IL-1 and TNF signaling". The EMBO Journal 22 (23): 6277–88. Dec 2003. doi:10.1093/emboj/cdg605. PMID 14633987.
- "TAB3, a new binding partner of the protein kinase TAK1". The Biochemical Journal 378 (Pt 1): 27–34. Feb 2004. doi:10.1042/BJ20031794. PMID 14670075.
- "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway". Nature Cell Biology 6 (2): 97–105. Feb 2004. doi:10.1038/ncb1086. PMID 14743216.
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