Biology:MXI1
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Short description: Protein-coding gene in humans
 Generic protein structure example |
MAX-interacting protein 1 is a protein that in humans is encoded by the MXI1 gene.[1][2]
Function
Expression of the c-myc gene, which produces an oncogenic transcription factor, is tightly regulated in normal cells but is frequently deregulated in human cancers. The protein encoded by this gene is a transcriptional repressor thought to negatively regulate MYC function, and is therefore a potential tumor suppressor. This protein inhibits the transcriptional activity of MYC by competing for MAX, another basic helix-loop-helix protein that binds to MYC and is required for its function. Defects in this gene are frequently found in patients with prostate tumors. Three alternatively spliced transcripts encoding different isoforms have been described. Additional alternatively spliced transcripts may exist but the products of these transcripts have not been verified experimentally.[2]
Interactions
MXI1 has been shown to interact with SMC3[3] and MAX.[3][4][5][6][7]
References
- ↑ "Localization of the human Mxi1 transcription factor gene (MXI1) to chromosome 10q24-q25". Genomics 21 (3): 669–72. Nov 1994. doi:10.1006/geno.1994.1336. PMID 7959753.
- ↑ 2.0 2.1 "Entrez Gene: MXI1 MAX interactor 1". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4601.
- ↑ 3.0 3.1 "Mmip1: a novel leucine zipper protein that reverses the suppressive effects of Mad family members on c-myc". Oncogene 16 (9): 1149–59. Mar 1998. doi:10.1038/sj.onc.1201634. PMID 9528857.
- ↑ "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. Oct 2005. doi:10.1038/nature04209. PMID 16189514. Bibcode: 2005Natur.437.1173R.
- ↑ "Mlx, a novel Max-like BHLHZip protein that interacts with the Max network of transcription factors". J. Biol. Chem. 274 (51): 36344–50. Dec 1999. doi:10.1074/jbc.274.51.36344. PMID 10593926.
- ↑ "Rox, a novel bHLHZip protein expressed in quiescent cells that heterodimerizes with Max, binds a non-canonical E box and acts as a transcriptional repressor". EMBO J. 16 (10): 2892–906. May 1997. doi:10.1093/emboj/16.10.2892. PMID 9184233.
- ↑ "Differential effects of the widely expressed dMax splice variant of Max on E-box vs initiator element-mediated regulation by c-Myc". Oncogene 18 (15): 2489–98. Apr 1999. doi:10.1038/sj.onc.1202611. PMID 10229200.
Further reading
- "Mxi1, a protein that specifically interacts with Max to bind Myc-Max recognition sites". Cell 72 (2): 223–32. 1993. doi:10.1016/0092-8674(93)90662-A. PMID 8425219.
- "Mxi1, a protein that specifically interacts with Max to bind Myc-Max recognition sites" (PDF). Cell 79 (2): following 388. 1994. PMID 7954804. http://download.cell.com/pdf/PII0092867494902062.pdf?intermediate=true.
- "Role of Mxi1 in ageing organ systems and the regulation of normal and neoplastic growth". Nature 393 (6684): 483–7. 1998. doi:10.1038/31008. PMID 9624006. Bibcode: 1998Natur.393..483S.
- "Mutation of the MXI1 gene in prostate cancer". Nat. Genet. 9 (3): 249–55. 1995. doi:10.1038/ng0395-249. PMID 7773287.
- "Redefinition of the coding sequence of the MXI1 gene and identification of a polymorphic repeat in the 3' non-coding region that allows the detection of loss of heterozygosity of chromosome 10q25 in glioblastomas". Hum. Genet. 95 (6): 709–11. 1995. doi:10.1007/BF00209493. PMID 7789959.
- "An amino-terminal domain of Mxi1 mediates anti-Myc oncogenic activity and interacts with a homolog of the yeast transcriptional repressor SIN3". Cell 80 (5): 777–86. 1995. doi:10.1016/0092-8674(95)90356-9. PMID 7889571.
- "Mapping of two genes encoding members of a distinct subfamily of MAX interacting proteins: MAD to human chromosome 2 and mouse chromosome 6, and MXI1 to human chromosome 10 and mouse chromosome 19". Oncogene 9 (2): 665–8. 1994. PMID 8290278.
- "Genomic organization of human MXI1, a putative tumor suppressor gene". Genomics 32 (3): 466–70. 1997. doi:10.1006/geno.1996.0144. PMID 8838813.
- "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. 1997. doi:10.1101/gr.6.9.791. PMID 8889548.
- "Expression, regulation and polymorphism of the mxi1 genes". Gene 176 (1–2): 45–8. 1997. doi:10.1016/0378-1119(96)00206-5. PMID 8918230.
- "Mmip1: a novel leucine zipper protein that reverses the suppressive effects of Mad family members on c-myc". Oncogene 16 (9): 1149–59. 1998. doi:10.1038/sj.onc.1201634. PMID 9528857.
- "Commonly occurring loss and mutation of the MXI1 gene in prostate cancer". Genes Chromosomes Cancer 22 (4): 295–304. 1999. doi:10.1002/(SICI)1098-2264(199808)22:4<295::AID-GCC5>3.0.CO;2-Q. PMID 9669667.
- "Mxi1 mutations in human neurofibrosarcomas". Jpn. J. Cancer Res. 90 (7): 740–6. 1999. doi:10.1111/j.1349-7006.1999.tb00809.x. PMID 10470286.
- "Expression of MXI1, a Myc antagonist, is regulated by Sp1 and AP2". J. Biol. Chem. 274 (40): 28794–802. 1999. doi:10.1074/jbc.274.40.28794. PMID 10497252.
- "Mxi1, a Myc antagonist, suppresses proliferation of DU145 human prostate cells". Prostate 47 (3): 194–204. 2001. doi:10.1002/pros.1063. PMID 11351349. https://deepblue.lib.umich.edu/bitstream/2027.42/34758/1/1063_ftp.pdf.
- "Dynamic in vivo interactions among Myc network members". Oncogene 20 (34): 4650–64. 2001. doi:10.1038/sj.onc.1204606. PMID 11498788.
- "Mxi1 inhibits the proliferation of U87 glioma cells through down-regulation of cyclin B1 gene expression". Br. J. Cancer 86 (3): 477–84. 2002. doi:10.1038/sj.bjc.6600065. PMID 11875718.
- "Loss of heterozygosity in the MXI1 gene is a frequent occurrence in melanoma". Mod. Pathol. 16 (10): 992–5. 2004. doi:10.1097/01.MP.0000087421.44975.1C. PMID 14559981.
External links
- MXI1+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
- FactorBook Mxi1
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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