Biology:MXI1

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Short description: Protein-coding gene in humans


A representation of the 3D structure of the protein myoglobin showing turquoise α-helices.
Generic protein structure example

MAX-interacting protein 1 is a protein that in humans is encoded by the MXI1 gene.[1][2]

Function

Expression of the c-myc gene, which produces an oncogenic transcription factor, is tightly regulated in normal cells but is frequently deregulated in human cancers. The protein encoded by this gene is a transcriptional repressor thought to negatively regulate MYC function, and is therefore a potential tumor suppressor. This protein inhibits the transcriptional activity of MYC by competing for MAX, another basic helix-loop-helix protein that binds to MYC and is required for its function. Defects in this gene are frequently found in patients with prostate tumors. Three alternatively spliced transcripts encoding different isoforms have been described. Additional alternatively spliced transcripts may exist but the products of these transcripts have not been verified experimentally.[2]

Interactions

MXI1 has been shown to interact with SMC3[3] and MAX.[3][4][5][6][7]

References

  1. "Localization of the human Mxi1 transcription factor gene (MXI1) to chromosome 10q24-q25". Genomics 21 (3): 669–72. Nov 1994. doi:10.1006/geno.1994.1336. PMID 7959753. 
  2. 2.0 2.1 "Entrez Gene: MXI1 MAX interactor 1". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4601. 
  3. 3.0 3.1 "Mmip1: a novel leucine zipper protein that reverses the suppressive effects of Mad family members on c-myc". Oncogene 16 (9): 1149–59. Mar 1998. doi:10.1038/sj.onc.1201634. PMID 9528857. 
  4. "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. Oct 2005. doi:10.1038/nature04209. PMID 16189514. Bibcode2005Natur.437.1173R. 
  5. "Mlx, a novel Max-like BHLHZip protein that interacts with the Max network of transcription factors". J. Biol. Chem. 274 (51): 36344–50. Dec 1999. doi:10.1074/jbc.274.51.36344. PMID 10593926. 
  6. "Rox, a novel bHLHZip protein expressed in quiescent cells that heterodimerizes with Max, binds a non-canonical E box and acts as a transcriptional repressor". EMBO J. 16 (10): 2892–906. May 1997. doi:10.1093/emboj/16.10.2892. PMID 9184233. 
  7. "Differential effects of the widely expressed dMax splice variant of Max on E-box vs initiator element-mediated regulation by c-Myc". Oncogene 18 (15): 2489–98. Apr 1999. doi:10.1038/sj.onc.1202611. PMID 10229200. 

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.