Biology:COUP-TFII
From HandWiki
COUP-TFII (COUP transcription factor 2), also known as NR2F2 (nuclear receptor subfamily 2, group F, member 2) is a protein that in humans is encoded by the NR2F2 gene.[1][2] It functions as a pro-ovary/anti-testis transcription factor during embryonic sexual differentiation, and in particular loss-of-function mutations of the gene are associated with differences of sexual development in children with XX chromosomes, together with cardiac defects.[3] The COUP acronym stands for chicken ovalbumin upstream promoter, which is older (pre-1999) terminology referencing the role of COUP-TFI and COUP-TFII in chickens, which were the first reported.[4]
Function
COUP-TFII plays a critical role in controlling the development of a number of tissues and organs including heart, blood vessels, muscles and limbs.[5][6]
The glucocorticoid receptor (GR) stimulates COUP-TFII-induced transactivation while COUP-TFII represses the GR transcriptional activity.[7][8] COUP-TFII interacts with GATA2 to inhibit adipocyte differentiation.[9]
Structure and ligands
The structure of COUP-TF2 LBD is known. Retinoic acid, although not at physiological concentrations, activate this receptor.[10]
Interactions
COUP-TFII has been shown to interact with:
References
- ↑ "Entrez Gene: NR2F2 nuclear receptor subfamily 2, group F, member 2". https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=7026.
- ↑ "Isolation, characterization, and chromosomal localization of mouse and human COUP-TF I and II genes". Genomics 29 (1): 240–6. September 1995. doi:10.1006/geno.1995.1237. PMID 8530078.
- ↑ "Loss of function of the nuclear receptor NR2F2, encoding COUP-TF2, causes testis development and cardiac defects in 46, XX children". The American Journal of Human Genetics 102 (3): 487-493. March 2018. doi:10.1016/j.ajhg.2018.01.021.
- ↑ "Structural and functional aspects of the neurodevelopmental gene NR2F1: from animal models to human pathology". Frontiers in Molecular Neuroscience 15. December 2021. doi:10.3389/fnmol.2021.767965.
- ↑ "The orphan nuclear receptor COUP-TFII is required for angiogenesis and heart development". Genes Dev. 13 (8): 1037–49. April 1999. doi:10.1101/gad.13.8.1037. PMID 10215630.
- ↑ "The Nuclear Orphan Receptor COUP-TFII Is Required for Limb and Skeletal Muscle Development". Mol. Cell. Biol. 24 (24): 10835–43. December 2004. doi:10.1128/MCB.24.24.10835-10843.2004. PMID 15572686.
- ↑ "The glucocorticoid receptor and the orphan nuclear receptor chicken ovalbumin upstream promoter-transcription factor II interact with and mutually affect each other's transcriptional activities: implications for intermediary metabolism". Mol. Endocrinol. 18 (4): 820–33. April 2004. doi:10.1210/me.2003-0341. PMID 14739255.
- ↑ "Interaction of the glucocorticoid receptor and the chicken ovalbumin upstream promoter-transcription factor II (COUP-TFII): implications for the actions of glucocorticoids on glucose, lipoprotein, and xenobiotic metabolism". Ann. N. Y. Acad. Sci. 1024 (1): 72–85. June 2004. doi:10.1196/annals.1321.006. PMID 15265774. Bibcode: 2004NYASA1024...72D. https://zenodo.org/record/1235874.
- ↑ "The orphan nuclear receptor chicken ovalbumin upstream promoter-transcription factor II is a critical regulator of adipogenesis". Proc. Natl. Acad. Sci. U.S.A. 105 (7): 2421–6. February 2008. doi:10.1073/pnas.0707082105. PMID 18250317. Bibcode: 2008PNAS..105.2421X.
- ↑ "Identification of COUP-TFII orphan nuclear receptor as a retinoic acid-activated receptor". PLOS Biology 6 (9). September 2008. doi:10.1371/journal.pbio.0060227. PMID 18798693.
- ↑ "Association of histone deacetylase with COUP-TF in tumorigenic Ad12-transformed cells and its potential role in shut-off of MHC class I transcription". Virology 268 (2): 319–28. March 2000. doi:10.1006/viro.1999.0181. PMID 10704340.
- ↑ "A p56(lck) ligand serves as a coactivator of an orphan nuclear hormone receptor". J. Biol. Chem. 271 (44): 27197–200. November 1996. doi:10.1074/jbc.271.44.27197. PMID 8910285.
- ↑ "Heterodimeric Interactions between Chicken Ovalbumin Upstream Promoter-Transcription Factor Family Members ARP1 and Ear2". J. Biol. Chem. 274 (20): 14331–6. May 1999. doi:10.1074/jbc.274.20.14331. PMID 10318855.
- ↑ "Identification and characterization of nucleolin as a COUP-TFII coactivator of retinoic acid receptor β transcription in breast cancer cells.". PLOS ONE 7 (5). May 2012. doi:10.1371/journal.pone.0038278. PMID 22693611. Bibcode: 2012PLoSO...738278L.
External links
- Human NR2F1 genome location and NR2F1 gene details page in the UCSC Genome Browser.
- Human NR2F2 genome location and NR2F2 gene details page in the UCSC Genome Browser.
- Overview of all the structural information available in the PDB for UniProt: P24468 (COUP transcription factor 2) at the PDBe-KB.
Further reading
- "Interaction of the glucocorticoid receptor and the chicken ovalbumin upstream promoter-transcription factor II (COUP-TFII): implications for the actions of glucocorticoids on glucose, lipoprotein, and xenobiotic metabolism". Ann. N. Y. Acad. Sci. 1024 (1): 72–85. 2004. doi:10.1196/annals.1321.006. PMID 15265774. Bibcode: 2004NYASA1024...72D. https://zenodo.org/record/1235874.
- "Antagonism between apolipoprotein AI regulatory protein 1, Ear3/COUP-TF, and hepatocyte nuclear factor 4 modulates apolipoprotein CIII gene expression in liver and intestinal cells". Mol. Cell. Biol. 12 (4): 1708–18. 1992. doi:10.1128/MCB.12.4.1708. PMID 1312668.
- "The COUP-TFs compose a family of functionally related transcription factors". Gene Expr. 1 (3): 207–16. 1992. PMID 1820218.
- "Regulation of the apolipoprotein AI gene by ARP-1, a novel member of the steroid receptor superfamily". Science 251 (4993): 561–5. 1991. doi:10.1126/science.1899293. PMID 1899293. Bibcode: 1991Sci...251..561L.
- "A p56(lck) ligand serves as a coactivator of an orphan nuclear hormone receptor". J. Biol. Chem. 271 (44): 27197–200. 1996. doi:10.1074/jbc.271.44.27197. PMID 8910285.
- "Differential interaction of nuclear receptors with the putative human transcriptional coactivator hTIF1". J. Biol. Chem. 272 (18): 12062–8. 1997. doi:10.1074/jbc.272.18.12062. PMID 9115274.
- "The nuclear orphan receptors COUP-TFII and Ear-2 act as silencers of the human oxytocin gene promoter". J. Mol. Endocrinol. 19 (2): 163–72. 1998. doi:10.1677/jme.0.0190163. PMID 9343308.
- "The orphan nuclear receptor, COUP-TF II, inhibits myogenesis by post-transcriptional regulation of MyoD function: COUP-TF II directly interacts with p300 and myoD". Nucleic Acids Res. 26 (23): 5501–10. 1999. doi:10.1093/nar/26.23.5501. PMID 9826778.
- "Heterodimeric Interactions between Chicken Ovalbumin Upstream Promoter-Transcription Factor Family Members ARP1 and Ear2". J. Biol. Chem. 274 (20): 14331–6. 1999. doi:10.1074/jbc.274.20.14331. PMID 10318855.
- "Association of histone deacetylase with COUP-TF in tumorigenic Ad12-transformed cells and its potential role in shut-off of MHC class I transcription". Virology 268 (2): 319–28. 2000. doi:10.1006/viro.1999.0181. PMID 10704340.
- "Isolation of a Novel Family of C2H2 Zinc Finger Proteins Implicated in Transcriptional Repression Mediated by Chicken Ovalbumin Upstream Promoter Transcription Factor (COUP-TF) Orphan Nuclear Receptors". J. Biol. Chem. 275 (14): 10315–22. 2000. doi:10.1074/jbc.275.14.10315. PMID 10744719.
- "Transcriptional regulation of the nuclear gene encoding the alpha-subunit of the mammalian mitochondrial F1F0 ATP synthase complex: role for the orphan nuclear receptor, COUP-TFII/ARP-1". Biochemistry 42 (9): 2656–63. 2003. doi:10.1021/bi0268347. PMID 12614160.
- "Immunolocalization of nuclear transcription factors, DAX-1 and COUP-TF II, in the normal human ovary: correlation with adrenal 4 binding protein/steroidogenic factor-1 immunolocalization during the menstrual cycle". J. Clin. Endocrinol. Metab. 88 (7): 3415–20. 2003. doi:10.1210/jc.2002-021723. PMID 12843196.
- "Functional Proteomics Mapping of a Human Signaling Pathway". Genome Res. 14 (7): 1324–32. 2004. doi:10.1101/gr.2334104. PMID 15231748.
- "Ubc9 and Protein Inhibitor of Activated STAT 1 Activate Chicken Ovalbumin Upstream Promoter-Transcription Factor I-mediated Human CYP11B2 Gene Transcription". J. Biol. Chem. 280 (8): 6721–30. 2005. doi:10.1074/jbc.M411820200. PMID 15611122.
- "COUP-TF and transcriptional co-regulators in adrenal steroidogenesis". Endocr. Res. 30 (4): 795–801. 2005. doi:10.1081/ERC-200044042. PMID 15666827.
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