Biology:BACH1

Short description: Protein-coding gene in the species Homo sapiens

Generic protein structure example

Transcription regulator protein BACH1 is a protein that in humans is encoded by the BACH1 gene.

Function

This gene encodes a transcription factor that belongs to the cap'n'collar type of basic region leucine zipper factor family (CNC-bZip). The encoded protein contains broad complex, tramtrack, bric-a-brac/poxvirus and zinc finger (BTB/POZ) domains, which is atypical of CNC-bZip family members. These BTB/POZ domains facilitate protein-protein interactions and formation of homo- and/or hetero-oligomers. The C-terminus of the protein is a leucine zipper of the bzip maf family. When this protein forms a heterodimer with MafK, it functions as a repressor of Maf recognition element (MARE) and transcription is repressed. Multiple alternatively spliced transcript variants have been identified for this gene. Some exons of this gene overlap with some exons from the C21orf41 gene, which is transcribed in an opposite orientation to this gene but does not seem to encode a protein.

See also

• Small Maf

Further reading

• "New biotechnological methods to reduce oxidative stress in the cardiovascular system: focusing on the Bach1/heme oxygenase-1 pathway". Current Pharmaceutical Biotechnology 7 (2): 87–93. Apr 2006. doi:10.2174/138920106776597630. PMID 16724942. 
• "Bach proteins belong to a novel family of BTB-basic leucine zipper transcription factors that interact with MafK and regulate transcription through the NF-E2 site". Molecular and Cellular Biology 16 (11): 6083–95. Nov 1996. doi:10.1128/mcb.16.11.6083. PMID 8887638. 
• "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research 6 (9): 791–806. Sep 1996. doi:10.1101/gr.6.9.791. PMID 8889548. 
• "A combinatorial code for gene expression generated by transcription factor Bach2 and MAZR (MAZ-related factor) through the BTB/POZ domain". Molecular and Cellular Biology 20 (5): 1733–46. Mar 2000. doi:10.1128/MCB.20.5.1733-1746.2000. PMID 10669750. 
• "Transcription factor BACH1 is recruited to the nucleus by its novel alternative spliced isoform". The Journal of Biological Chemistry 276 (10): 7278–84. Mar 2001. doi:10.1074/jbc.M004227200. PMID 11069897. 
• "BACH1, a novel helicase-like protein, interacts directly with BRCA1 and contributes to its DNA repair function". Cell 105 (1): 149–60. Apr 2001. doi:10.1016/S0092-8674(01)00304-X. PMID 11301010. 
• "Bach1 functions as a hypoxia-inducible repressor for the heme oxygenase-1 gene in human cells". The Journal of Biological Chemistry 278 (11): 9125–33. Mar 2003. doi:10.1074/jbc.M209939200. PMID 12511571. 
• "Cadmium induces nuclear export of Bach1, a transcriptional repressor of heme oxygenase-1 gene". The Journal of Biological Chemistry 278 (49): 49246–53. Dec 2003. doi:10.1074/jbc.M306764200. PMID 14504288. 
• "Heme positively regulates the expression of beta-globin at the locus control region via the transcriptional factor Bach1 in erythroid cells". The Journal of Biological Chemistry 279 (7): 5480–7. Feb 2004. doi:10.1074/jbc.M302733200. PMID 14660636. 
• "Aberrant protein expression of transcription factors BACH1 and ERG, both encoded on chromosome 21, in brains of patients with Down syndrome and Alzheimer's disease". Advances in Down Syndrome Research. Journal of Neural Transmission Supplement 67. 67. 2003. 39–49. doi:10.1007/978-3-7091-6721-2_3. ISBN 978-3-211-40776-9. 
• "Overexpression of transcription factor BACH1 in fetal Down Syndrome brain". Advances in Down Syndrome Research. Journal of Neural Transmission Supplement 67. 67. 2003. 193–205. doi:10.1007/978-3-7091-6721-2_17. ISBN 978-3-211-40776-9. 
• "Heme regulates gene expression by triggering Crm1-dependent nuclear export of Bach1". The EMBO Journal 23 (13): 2544–53. Jul 2004. doi:10.1038/sj.emboj.7600248. PMID 15175654. 
• "Heme-dependent up-regulation of the alpha-globin gene expression by transcriptional repressor Bach1 in erythroid cells". Biochemical and Biophysical Research Communications 324 (1): 77–85. Nov 2004. doi:10.1016/j.bbrc.2004.09.022. PMID 15464985. http://ir.lib.hiroshima-u.ac.jp/files/public/2/21534/20141016141157698753/BBRC_324_77.pdf. 
• "Role of Bach-1 in regulation of heme oxygenase-1 in human liver cells: insights from studies with small interfering RNAS". The Journal of Biological Chemistry 279 (50): 51769–74. Dec 2004. doi:10.1074/jbc.M409463200. PMID 15465821. 
• "Transgenic expression of BACH1 transcription factor results in megakaryocytic impairment". Blood 105 (8): 3100–8. Apr 2005. doi:10.1182/blood-2004-07-2826. PMID 15613547. 

External links

• BACH1+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
• Human BACH1 genome location and BACH1 gene details page in the UCSC Genome Browser.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.