Biology:BACH1

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Short description: Protein-coding gene in the species Homo sapiens


A representation of the 3D structure of the protein myoglobin showing turquoise α-helices.
Generic protein structure example

Transcription regulator protein BACH1 is a protein that in humans is encoded by the BACH1 gene.[1][2][3]

Function

This gene encodes a transcription factor that belongs to the cap'n'collar type of basic region leucine zipper factor family (CNC-bZip). The encoded protein contains broad complex, tramtrack, bric-a-brac/poxvirus and zinc finger (BTB/POZ) domains, which is atypical of CNC-bZip family members. These BTB/POZ domains facilitate protein-protein interactions and formation of homo- and/or hetero-oligomers. The C-terminus of the protein is a leucine zipper of the bzip maf family. When this protein forms a heterodimer with MafK, it functions as a repressor of Maf recognition element (MARE) and transcription is repressed. Multiple alternatively spliced transcript variants have been identified for this gene. Some exons of this gene overlap with some exons from the C21orf41 gene, which is transcribed in an opposite orientation to this gene but does not seem to encode a protein.[3]

See also

References

  1. "Isolation of the human BACH1 transcription regulator gene, which maps to chromosome 21q22.1". Human Genetics 102 (3): 282–8. Mar 1998. doi:10.1007/s004390050692. PMID 9544839. 
  2. "Characterization of a human homolog (BACH1) of the mouse Bach1 gene encoding a BTB-basic leucine zipper transcription factor and its mapping to chromosome 21q22.1". Genomics 47 (2): 300–6. Jan 1998. doi:10.1006/geno.1997.5080. PMID 9479503. 
  3. 3.0 3.1 "Entrez Gene: BACH1 BTB and CNC homology 1, basic leucine zipper transcription factor 1". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=571. 

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.