Biology:KLF13
Generic protein structure example |
Kruppel-like factor 13, also known as KLF13, is a protein that in humans is encoded by the KLF13 gene.[1][2][3]
There is some evidence for KLF13 having a role in obesity. A methylation site, cg07814318, within the first intron of KLF13 has been associated with obesity and orexigenic processes.[4] Ghrelin levels also positively correlated with methylation levels of cg07814318.[4] Moreover, expression levels of KLF13 were decreased and increased in the brains of starved and obese mice, respectively.[4]
Function
KLF13 belongs to a family of transcription factors that contain 3 classical zinc finger DNA-binding domains consisting of a zinc atom tetrahedrally coordinated by 2 cysteines and 2 histidines (C2H2 motif). These transcription factors bind to GC-rich sequences and related GT and CACCC boxes.[1][5]
KLF13 was first described as the RANTES factor of late activated T lymphocytes (RFLAT)-1.[3] It regulates the expression of the chemokine RANTES in T lymphocytes. It functions as a lynchpin, inducing a large enhancesome. KLF13 knock-out mice show a defect in lymphocyte survival as KLF13 is a regulator of Bcl-xL expression.[3][6][7][8][9][10][11]
Interactions
KLF13 has been shown to interact with CREB-binding protein,[12] Heat shock protein 47[12] and PCAF.[12]
See also
References
- ↑ 1.0 1.1 "Entrez Gene: KLF13 Kruppel-like factor 13". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51621.
- ↑ "Sp1 and its likes: biochemical and functional predictions for a growing family of zinc finger transcription factors". Annals of the New York Academy of Sciences 880 (1 CELL AND MOLE): 94–102. Jun 1999. doi:10.1111/j.1749-6632.1999.tb09513.x. PMID 10415854. Bibcode: 1999NYASA.880...94C.
- ↑ 3.0 3.1 3.2 "RFLAT-1: a new zinc finger transcription factor that activates RANTES gene expression in T lymphocytes". Immunity 10 (1): 93–103. Jan 1999. doi:10.1016/S1074-7613(00)80010-2. PMID 10023774.
- ↑ 4.0 4.1 4.2 "A DNA methylation site within the KLF13 gene is associated with orexigenic processes based on neural responses and ghrelin levels.". Int J Obes (Lond) 43 (6): 990–994. 14 Feb 2017. doi:10.1038/ijo.2017.43. PMID 28194012.
- ↑ "Identification of KLF13 and KLF14 (SP6), novel members of the SP/XKLF transcription factor family". Genomics 70 (1): 93–101. Nov 2000. doi:10.1006/geno.2000.6362. PMID 11087666.
- ↑ "Transcriptional regulation of RANTES expression in T lymphocytes". Immunological Reviews 177 (1): 236–45. Oct 2000. doi:10.1034/j.1600-065X.2000.17610.x. PMID 11138780.
- ↑ "A translational rheostat for RFLAT-1 regulates RANTES expression in T lymphocytes". The Journal of Clinical Investigation 110 (1): 119–26. Jul 2002. doi:10.1172/JCI15336. PMID 12093895.
- ↑ "Functional domains and DNA-binding sequences of RFLAT-1/KLF13, a Krüppel-like transcription factor of activated T lymphocytes". The Journal of Biological Chemistry 277 (33): 30055–65. Aug 2002. doi:10.1074/jbc.M204278200. PMID 12050170.
- ↑ "Kruppel-like transcription factor 13 regulates T lymphocyte survival in vivo". Journal of Immunology 178 (9): 5496–504. May 2007. doi:10.4049/jimmunol.178.9.5496. PMID 17442931.
- ↑ "Interaction of PRP4 with Kruppel-like factor 13 regulates CCL5 transcription". Journal of Immunology 178 (11): 7081–7. Jun 2007. doi:10.4049/jimmunol.178.11.7081. PMID 17513757.
- ↑ "Dynamic interplay of transcriptional machinery and chromatin regulates "late" expression of the chemokine RANTES in T lymphocytes". Molecular and Cellular Biology 27 (1): 253–66. Jan 2007. doi:10.1128/MCB.01071-06. PMID 17074812.
- ↑ 12.0 12.1 12.2 "Functional interaction between coactivators CBP/p300, PCAF, and transcription factor FKLF2". The Journal of Biological Chemistry 277 (9): 7029–36. Mar 2002. doi:10.1074/jbc.M108826200. PMID 11748222.
Further reading
- "Sp1 and its likes: biochemical and functional predictions for a growing family of zinc finger transcription factors". Annals of the New York Academy of Sciences 880 (1 CELL AND MOLE): 94–102. Jun 1999. doi:10.1111/j.1749-6632.1999.tb09513.x. PMID 10415854. Bibcode: 1999NYASA.880...94C.
- "RFLAT-1: a new zinc finger transcription factor that activates RANTES gene expression in T lymphocytes". Immunity 10 (1): 93–103. Jan 1999. doi:10.1016/S1074-7613(00)80010-2. PMID 10023774.
- "FKLF-2: a novel Krüppel-like transcriptional factor that activates globin and other erythroid lineage genes". Blood 95 (11): 3578–84. Jun 2000. doi:10.1182/blood.V95.11.3578. PMID 10828046.
- "Identification of KLF13 and KLF14 (SP6), novel members of the SP/XKLF transcription factor family". Genomics 70 (1): 93–101. Nov 2000. doi:10.1006/geno.2000.6362. PMID 11087666.
- "The Sp1-like protein BTEB3 inhibits transcription via the basic transcription element box by interacting with mSin3A and HDAC-1 co-repressors and competing with Sp1". The Journal of Biological Chemistry 276 (39): 36749–56. Sep 2001. doi:10.1074/jbc.M105831200. PMID 11477107.
- "Functional interaction between coactivators CBP/p300, PCAF, and transcription factor FKLF2". The Journal of Biological Chemistry 277 (9): 7029–36. Mar 2002. doi:10.1074/jbc.M108826200. PMID 11748222.
- "Functional analysis of basic transcription element (BTE)-binding protein (BTEB) 3 and BTEB4, a novel Sp1-like protein, reveals a subfamily of transcriptional repressors for the BTE site of the cytochrome P4501A1 gene promoter". The Biochemical Journal 366 (Pt 3): 873–82. Sep 2002. doi:10.1042/BJ20020388. PMID 12036432.
- "Functional domains and DNA-binding sequences of RFLAT-1/KLF13, a Krüppel-like transcription factor of activated T lymphocytes". The Journal of Biological Chemistry 277 (33): 30055–65. Aug 2002. doi:10.1074/jbc.M204278200. PMID 12050170.
- "A translational rheostat for RFLAT-1 regulates RANTES expression in T lymphocytes". The Journal of Clinical Investigation 110 (1): 119–26. Jul 2002. doi:10.1172/JCI15336. PMID 12093895.
- "Transcriptional regulation of FKLF-2 (KLF13) gene in erythroid cells". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression 1727 (2): 125–33. Feb 2005. doi:10.1016/j.bbaexp.2004.12.007. PMID 15716005.
- "A functional screen for Krüppel-like factors that regulate the human gamma-globin gene through the CACCC promoter element". Blood Cells, Molecules & Diseases 35 (2): 227–35. 2006. doi:10.1016/j.bcmd.2005.04.009. PMID 16023392.
- "Dynamic interplay of transcriptional machinery and chromatin regulates "late" expression of the chemokine RANTES in T lymphocytes". Molecular and Cellular Biology 27 (1): 253–66. Jan 2007. doi:10.1128/MCB.01071-06. PMID 17074812.
- "Interaction of PRP4 with Kruppel-like factor 13 regulates CCL5 transcription". Journal of Immunology 178 (11): 7081–7. Jun 2007. doi:10.4049/jimmunol.178.11.7081. PMID 17513757.
External links
- KLF13+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
Original source: https://en.wikipedia.org/wiki/KLF13.
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