Biology:ARID3B

Short description: Protein-coding gene in the species Homo sapiens

Generic protein structure example

AT-rich interactive domain-containing protein 3B is a protein that in humans is encoded by the ARID3B gene.

Function

This gene encodes a member of the ARID (AT-rich interaction domain) family of DNA-binding proteins. The encoded protein is homologous with two proteins that bind to the retinoblastoma gene product, and also with the mouse Bright and Drosophila dead ringer proteins. A pseudogene on chromosome 1p31 exists for this gene. Members of the ARID family have roles in embryonic patterning, cell lineage gene regulation, cell cycle control, transcriptional regulation and possibly in chromatin structure modification.

Further reading

• "ARID proteins come in from the desert". Trends in Biochemical Sciences 25 (6): 294–9. Jun 2000. doi:10.1016/S0968-0004(00)01597-8. PMID 10838570. 
• "Bdp, a new member of a family of DNA-binding proteins, associates with the retinoblastoma gene product". Cancer Research 59 (15): 3741–7. Aug 1999. PMID 10446990. 
• "let-7 Modulates Chromatin Configuration and Target Gene Repression through Regulation of the ARID3B Complex". Cell Reports 14 (3): 520–33. 2016. doi:10.1016/j.celrep.2015.12.064. PMID 26776511. 

External links

• ARID3B+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
• Human ARID3B genome location and ARID3B gene details page in the UCSC Genome Browser.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.