Biology:TEAD4

From HandWiki
Short description: Protein-coding gene in the species Homo sapiens


A representation of the 3D structure of the protein myoglobin showing turquoise α-helices.
Generic protein structure example

Transcriptional enhancer factor TEF-3 is a protein that in humans is encoded by the TEAD4 gene.[1][2][3]

Function

This gene product is a member of the transcriptional enhancer factor (TEF) family of transcription factors, which contain the TEA/ATTS DNA-binding domain.[4] Members of the family in mammals are TEAD1, TEAD2, TEAD3, TEAD4. TEAD4 is preferentially expressed in the skeletal muscle, and binds to the M-CAT regulatory element found in promoters of muscle-specific genes to direct their gene expression. Alternatively spliced transcripts encoding distinct isoforms, some of which are translated through the use of a non-AUG (UUG) initiation codon, have been described for this gene.[3] Gene ablation experiments in mice (i.e. knockout mice) showed that TEAD4 is essential for the formation of blastocysts during preimplantation embryo development.[5][6] Although it was originally hypothesized to be essential for specification of trophectoderm lineage, it was later shown that functional trophectoderm can be produced leading to formation of blastocysts under in vitro conditions that suppress oxidative stress.[7] Transcriptional coregulators, such as WWTR1 (TAZ) bind to members in this transcription factor family.

References

  1. ↑ "Localization of human transcription factor TEF-4 and TEF-5 (TEAD2, TEAD3) genes to chromosomes 19q13.3 and 6p21.2 using fluorescence in situ hybridization and radiation hybrid analysis". Genomics 55 (1): 127–9. January 1999. doi:10.1006/geno.1998.5628. PMID 9889009. 
  2. ↑ "Cloning of human RTEF-1, a transcriptional enhancer factor-1-related gene preferentially expressed in skeletal muscle: evidence for an ancient multigene family". Genomics 37 (1): 68–76. October 1996. doi:10.1006/geno.1996.0522. PMID 8921372. 
  3. ↑ 3.0 3.1 "Entrez Gene: TEAD4 TEA domain family member 4". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7004. 
  4. ↑ "The TEA domain: a novel, highly conserved DNA-binding motif". Cell 66 (1): 11–2. July 1991. doi:10.1016/0092-8674(91)90132-I. PMID 2070413. 
  5. ↑ "Transcription factor TEAD4 specifies the trophectoderm lineage at the beginning of mammalian development". Development 134 (21): 3827–36. November 2007. doi:10.1242/dev.010223. PMID 17913785. 
  6. ↑ "Tead4 is required for specification of trophectoderm in pre-implantation mouse embryos". Mechanisms of Development 125 (3–4): 270–83. 2008. doi:10.1016/j.mod.2007.11.002. PMID 18083014. 
  7. ↑ "TEAD4 establishes the energy homeostasis essential for blastocoel formation". Development 140 (17): 3680–90. September 2013. doi:10.1242/dev.093799. PMID 23903192. 

Further reading

External links



Retrieved from "https://handwiki.org/wiki/index.php?title=Biology:TEAD4&oldid=2870174"