Biology:MEOX2
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Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Mesenchyme homeobox 2 (MEOX2) is a protein that in humans is encoded by the MEOX2 gene.[1][2]
Function
This gene encodes a member of a subfamily of non-clustered, diverged, antennapedia-like homeobox-containing transcription factor genes. The encoded protein may play a role in the regulation of vertebrate limb myogenesis. Mutations in the related mouse protein may be associated with craniofacial and/or skeletal abnormalities, in addition to neurovascular dysfunction observed in Alzheimer's disease.[2] MEOX2 has been implicated in the initiation of tumors in glioma.[3] Additionally, MEOX2 influences several critical processes in lung cancer, including cellular proliferation, invasion, metastasis, angiogenesis, and the development of drug resistance.[4][5][6]
Interactions
MEOX2 has been shown to interact with PAX1[7] and PAX3.[7]
References
- ↑ "Molecular cloning and localization of the human GAX gene to 7p21". Genomics 24 (3): 535–540. December 1994. doi:10.1006/geno.1994.1663. PMID 7713505.
- ↑ 2.0 2.1 "Entrez Gene: MEOX2 mesenchyme homeobox 2". https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=4223.
- ↑ "MEOX2-mediated regulation of Cathepsin S promotes cell proliferation and motility in glioma". Cell Death & Disease 13 (4). April 2022. doi:10.1038/s41419-022-04845-2. PMID 35436995.
- ↑ "Epigenomic study identifies a novel mesenchyme homeobox2-GLI1 transcription axis involved in cancer drug resistance, overall survival and therapy prognosis in lung cancer patients". Oncotarget 8 (40): 67056–67081. September 2017. doi:10.18632/oncotarget.17715. PMID 28978016.
- ↑ "Failure to EGFR-TKI-based therapy and tumoural progression are promoted by MEOX2/GLI1-mediated epigenetic regulation of EGFR in the human lung cancer". European Journal of Cancer 160: 189–205. January 2022. doi:10.1016/j.ejca.2021.10.032. PMID 34844838.
- ↑ "SMARCB1-driven EGFR-GLI1 epigenetic alterations in lung cancer progression and therapy are differentially modulated by MEOX2 and GLI-1". Cancer Gene Therapy 32 (3): 327–342. March 2025. doi:10.1038/s41417-025-00873-0. PMID 39971779.
- ↑ 7.0 7.1 "Homeodomain proteins Mox1 and Mox2 associate with Pax1 and Pax3 transcription factors". FEBS Letters 499 (3): 274–278. June 2001. doi:10.1016/S0014-5793(01)02556-X. PMID 11423130. Bibcode: 2001FEBSL.499..274S.
Further reading
- "Isolation of the human MOX2 homeobox gene and localization to chromosome 7p22.1-p21.3". Genomics 26 (3): 550–555. April 1995. doi:10.1016/0888-7543(95)80174-K. PMID 7607679.
- "Cytogenetic evidence that the Saethre-Chotzen gene maps to 7p21.2". American Journal of Medical Genetics 47 (5): 633–636. October 1993. doi:10.1002/ajmg.1320470510. PMID 8266988.
- "The homeobox genes MSX2 and MOX2 are candidates for regulating epithelial-mesenchymal cell interactions in the human placenta". Placenta 21 (Suppl A): S50–S54. 2000. doi:10.1053/plac.1999.0514. PMID 10831122.
- "Homeodomain proteins Mox1 and Mox2 associate with Pax1 and Pax3 transcription factors". FEBS Letters 499 (3): 274–278. June 2001. doi:10.1016/S0014-5793(01)02556-X. PMID 11423130. Bibcode: 2001FEBSL.499..274S.
- "Inhibition of endothelial cell activation by the homeobox gene Gax". The Journal of Surgical Research 111 (1): 91–99. May 2003. doi:10.1016/S0022-4804(03)00042-8. PMID 12842453.
- "Role of the MEOX2 homeobox gene in neurovascular dysfunction in Alzheimer disease". Nature Medicine 11 (9): 959–965. September 2005. doi:10.1038/nm1287. PMID 16116430.
- "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–1178. October 2005. doi:10.1038/nature04209. PMID 16189514. Bibcode: 2005Natur.437.1173R.
- "Characterization of Mesenchyme Homeobox 2 (MEOX2) transcription factor binding to RING finger protein 10". Molecular and Cellular Biochemistry 275 (1–2): 75–84. July 2005. doi:10.1007/s11010-005-0823-3. PMID 16335786.
- "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Research 16 (1): 55–65. January 2006. doi:10.1101/gr.4039406. PMID 16344560.
- "The homeobox gene GAX activates p21WAF1/CIP1 expression in vascular endothelial cells through direct interaction with upstream AT-rich sequences". The Journal of Biological Chemistry 282 (1): 507–517. January 2007. doi:10.1074/jbc.M606604200. PMID 17074759.
External links
- MEOX2+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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