Biology:ZNF384
 Generic protein structure example |
Zinc finger protein 384 is a protein that in humans is encoded by the ZNF384 gene.[1][2][3]
Function
This gene encodes a C2H2-type zinc finger protein, which may function as a transcription factor. This gene also contains long CAG trinucleotide repeats that encode consecutive glutamine residues. The protein appears to bind and regulate the promoters of the extracellular matrix genes MMP1, MMP3, MMP7 and COL1A1. Studies in mouse suggest that ZNF384 may be part of a general mechanical pathway that couples cell construction and function during extracellular matrix remodeling. Alternative splicing results in multiple transcript variants.[3]
Clinical significance
Recurrent rearrangements of this gene with the Ewing's sarcoma gene, EWSR1 on chromosome 22, or with the TAF15 gene on chromosome 17, or with the TCF3 (E2A) gene on chromosome 19, have been observed in acute leukemia.[3]
References
- ↑ "cDNAs with long CAG trinucleotide repeats from human brain". Human Genetics 100 (1): 114–22. Jul 1997. doi:10.1007/s004390050476. PMID 9225980.
- ↑ "Cloning and functional analysis of a family of nuclear matrix transcription factors (NP/NMP4) that regulate type I collagen expression in osteoblasts". Journal of Bone and Mineral Research 16 (1): 10–23. Jan 2001. doi:10.1359/jbmr.2001.16.1.10. PMID 11149472.
- ↑ 3.0 3.1 3.2 "Entrez Gene: ZNF384 zinc finger protein 384". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=171017.
Further reading
- "Nucleotide sequence of the MHC class I genomic region of a teleost, the medaka (Oryzias latipes)". Immunogenetics 53 (10–11): 930–40. Feb 2002. doi:10.1007/s00251-001-0427-3. PMID 11862394.
- "MIB-1, p53, bcl-2, and WAF-1 expression in pelvic lymph nodes and primary tumors in early stage cervical carcinomas: correlation with clinical outcome". International Journal of Oncology 20 (5): 1041–7. May 2002. doi:10.3892/ijo.20.5.1041. PMID 11956602.
- "Recurrent rearrangement of the Ewing's sarcoma gene, EWSR1, or its homologue, TAF15, with the transcription factor CIZ/NMP4 in acute leukemia". Cancer Research 62 (19): 5408–12. Oct 2002. PMID 12359745.
- "Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions". Genome Research 14 (9): 1711–8. Sep 2004. doi:10.1101/gr.2435604. PMID 15342556.
- "CIZ gene rearrangements in acute leukemia: report of a diagnostic FISH assay and clinical features of nine patients". Leukemia 19 (9): 1696–9. Sep 2005. doi:10.1038/sj.leu.2403842. PMID 15990865.
- "Interaction partners for human ZNF384/CIZ/NMP4--zyxin as a mediator for p130CAS signaling?". Experimental Cell Research 312 (7): 1194–204. Apr 2006. doi:10.1016/j.yexcr.2006.02.001. PMID 16510139.
External links
- ZNF384+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
 |  |
