Biology:Aryl hydrocarbon receptor repressor
| aryl-hydrocarbon receptor repressor | |
|---|---|
| Identifiers | |
| Symbol | AHRR |
| Alt. symbols | AHH, AHHR |
| NCBI gene | 57491 |
| HGNC | 346 |
| OMIM | 606517 |
| RefSeq | NM_020731 |
| UniProt | Q9ULI6 |
| Other data | |
| Locus | Chr. 5 p15.33 |
The aryl-hydrocarbon receptor repressor also known as AHRR is a human gene.[1]
Function
Dioxins and dioxin-like compounds are teratogens that exert their effects through the aryl hydrocarbon receptor (AhR) in conjunction with the receptor's binding partner, aryl hydrocarbon receptor nuclear translocator (ARNT). The protein encoded by this gene represses signal transduction by the AhR by competing with the arylhydrocarbon receptor for binding to the ARNT.[2] Expression of the repressor is stimulated by the receptor/translocator heterodimer, thereby regulating receptor function through a negative feedback mechanism. In addition, the encoded protein can bind to nuclear factor-kappa B.
The AhRR gene may act as a tumor suppressor.[3][4]
Tissue distribution
The expression of AhRR is high in testis, lung, ovary, spleen and pancreas in adults, whereas expression is low in all tissues in fetuses.[5]
References
- ↑ "Structure and expression of the Ah receptor repressor gene". J. Biol. Chem. 276 (35): 33101–10. August 2001. doi:10.1074/jbc.M011497200. PMID 11423533.
- ↑ "Repression of aryl hydrocarbon receptor (AHR) signaling by AHR repressor: role of DNA binding and competition for AHR nuclear translocator". Mol. Pharmacol. 73 (2): 387–98. February 2008. doi:10.1124/mol.107.040204. PMID 18000031.
- ↑ "The aryl hydrocarbon receptor repressor is a putative tumor suppressor gene in multiple human cancers". J. Clin. Invest. 118 (2): 640–50. February 2008. doi:10.1172/JCI30024. PMID 18172554.
- ↑ "The Inhibitory Effect of Aryl Hydrocarbon Receptor Repressor (AhRR) on the Growth of Human Breast Cancer MCF-7 Cells". Biol. Pharm. Bull. 29 (6): 1254–7. June 2006. doi:10.1248/bpb.29.1254. PMID 16755028.
- ↑ "Characteristic expression of aryl hydrocarbon receptor repressor gene in human tissues: organ-specific distribution and variable induction patterns in mononuclear cells". Life Sci. 74 (8): 1039–49. January 2004. doi:10.1016/j.lfs.2003.07.022. PMID 14672759.
External links
- AHRR+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
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