Biology:HSF2

Short description: Protein-coding gene in the species Homo sapiens

Generic protein structure example

Heat shock factor protein 2 is a protein that in humans is encoded by the HSF2 gene.

Function

HSF2, as well as the related gene HSF1, encodes a protein that binds specifically to the heat-shock element and has homology to HSFs of other species. Heat shock transcription factors activate heat-shock response genes under conditions of heat or other stresses. Although the names HSF1 and HSF2 were chosen for historical reasons, these peptides should be referred to as heat-shock transcription factors.

Interactions

HSF2 has been shown to interact with Nucleoporin 62 and HSF1.

See also

• Heat shock factor

Further reading

• "Heat shock and the role of the HSPs during neural plate induction in early mammalian CNS and brain development.". Cell. Mol. Life Sci. 53 (2): 198–211. 1997. doi:10.1007/PL00000592. PMID 9118008. 
• "Cloning and characterization of two mouse heat shock factors with distinct inducible and constitutive DNA-binding ability.". Genes Dev. 5 (10): 1902–11. 1991. doi:10.1101/gad.5.10.1902. PMID 1717345. 
• "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1–2): 171–4. 1994. doi:10.1016/0378-1119(94)90802-8. PMID 8125298. 
• "Hydrophobic coiled-coil domains regulate the subcellular localization of human heat shock factor 2.". Genes Dev. 7 (8): 1549–58. 1993. doi:10.1101/gad.7.8.1549. PMID 8339932. 
• "The trimerization domain of human heat shock factor 2 is able to interact with nucleoporin p62.". Biochem. Biophys. Res. Commun. 240 (1): 228–33. 1997. doi:10.1006/bbrc.1997.7662. PMID 9367915. 
• "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1–2): 149–56. 1997. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149. 
• "Novel testis-specific protein that interacts with heat shock factor 2.". Gene 214 (1–2): 139–46. 1998. doi:10.1016/S0378-1119(98)00208-X. PMID 9651507. 
• "Regulation of protein phosphatase 2A activity by heat shock transcription factor 2.". J. Biol. Chem. 274 (19): 12967–70. 1999. doi:10.1074/jbc.274.19.12967. PMID 10224043. 
• "Sumo-1 modification regulates the DNA binding activity of heat shock transcription factor 2, a promyelocytic leukemia nuclear body associated transcription factor.". J. Biol. Chem. 276 (21): 18513–8. 2001. doi:10.1074/jbc.M008066200. PMID 11278381. 
• "Genomic organization and promoter analysis of the human heat shock factor 2 gene.". Cell Stress & Chaperones 6 (4): 377–85. 2002. PMID 11795475. 
• "Elevated expression of heat shock factor (HSF) 2A stimulates HSF1-induced transcription during stress.". J. Biol. Chem. 278 (37): 35465–75. 2003. doi:10.1074/jbc.M304663200. PMID 12813038. 
• "Formation of nuclear stress granules involves HSF2 and coincides with the nucleolar localization of Hsp70.". J. Cell Sci. 116 (Pt 17): 3557–70. 2004. doi:10.1242/jcs.00671. PMID 12865437. 
• "Functional role for heat shock factors in the transcriptional regulation of human RANK ligand gene expression in stromal/osteoblast cells.". J. Biol. Chem. 279 (11): 10500–7. 2004. doi:10.1074/jbc.M303727200. PMID 14699143. 
• "Mechanism of hsp70i gene bookmarking.". Science 307 (5708): 421–3. 2005. doi:10.1126/science.1106478. PMID 15662014. Bibcode: 2005Sci...307..421X. 
• "Inhibition of DNA binding by differential sumoylation of heat shock factors.". Mol. Cell. Biol. 26 (3): 955–64. 2006. doi:10.1128/MCB.26.3.955-964.2006. PMID 16428449. 

External links

• HSF2+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.