Biology:MAF (gene)
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Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Transcription factor Maf also known as proto-oncogene c-Maf or V-maf musculoaponeurotic fibrosarcoma oncogene homolog is a transcription factor that in humans is encoded by the MAF gene.[1][2]
Types
One type, MafA, also known as RIPE3b1,[3] promotes pancreatic development, as well as insulin gene transcription.[4]
Interactions
MAF has been shown to interact with:
References
- ↑ "Entrez Gene: MAF v-maf musculoaponeurotic fibrosarcoma oncogene homolog (avian)". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4094.
- ↑ "v-maf, a viral oncogene that encodes a "leucine zipper" motif". Proceedings of the National Academy of Sciences of the United States of America 86 (20): 7711–5. Oct 1989. doi:10.1073/pnas.86.20.7711. PMID 2554284. Bibcode: 1989PNAS...86.7711N.
- ↑ "Identification of beta-cell-specific insulin gene transcription factor RIPE3b1 as mammalian MafA". Proceedings of the National Academy of Sciences of the United States of America 99 (10): 6737–42. May 2002. doi:10.1073/pnas.102168499. PMID 12011435. Bibcode: 2002PNAS...99.6737O.
- ↑ "Regulation of insulin gene transcription". Diabetologia 45 (3): 309–26. Mar 2002. doi:10.1007/s00125-001-0728-y. PMID 11914736.
- ↑ 5.0 5.1 "CREB-binding protein/p300 co-activation of crystallin gene expression". The Journal of Biological Chemistry 277 (27): 24081–9. Jul 2002. doi:10.1074/jbc.M201821200. PMID 11943779.
- ↑ "c-Maf interacts with c-Myb to regulate transcription of an early myeloid gene during differentiation". Molecular and Cellular Biology 18 (5): 2729–37. May 1998. doi:10.1128/MCB.18.5.2729. PMID 9566892.
- ↑ "A new long form of c-Maf cooperates with Sox9 to activate the type II collagen gene". The Journal of Biological Chemistry 277 (52): 50668–75. Dec 2002. doi:10.1074/jbc.M206544200. PMID 12381733.
Further reading
- "Maf and Nrl can bind to AP-1 sites and form heterodimers with Fos and Jun". Oncogene 9 (3): 675–84. Mar 1994. PMID 8108109.
- "USF2/FIP associates with the b-Zip transcription factor, c-Maf, via its bHLH domain and inhibits c-Maf DNA binding activity". Biochemical and Biophysical Research Communications 231 (2): 333–9. Feb 1997. doi:10.1006/bbrc.1997.6097. PMID 9070273.
- "c-Maf interacts with c-Myb to regulate transcription of an early myeloid gene during differentiation". Molecular and Cellular Biology 18 (5): 2729–37. May 1998. doi:10.1128/MCB.18.5.2729. PMID 9566892.
- "Frequent dysregulation of the c-maf proto-oncogene at 16q23 by translocation to an Ig locus in multiple myeloma". Blood 91 (12): 4457–63. Jun 1998. doi:10.1182/blood.V91.12.4457. PMID 9616139.
- "TH2 cytokine-associated transcription factors in atopic and nonatopic asthma: evidence for differential signal transducer and activator of transcription 6 expression". The Journal of Allergy and Clinical Immunology 107 (4): 586–91. Apr 2001. doi:10.1067/mai.2001.114883. PMID 11295643.
- "Domain disruption and mutation of the bZIP transcription factor, MAF, associated with cataract, ocular anterior segment dysgenesis and coloboma". Human Molecular Genetics 11 (1): 33–42. Jan 2002. doi:10.1093/hmg/11.1.33. PMID 11772997.
- "CREB-binding protein/p300 co-activation of crystallin gene expression". The Journal of Biological Chemistry 277 (27): 24081–9. Jul 2002. doi:10.1074/jbc.M201821200. PMID 11943779.
- "c-Maf negatively regulates ARE-mediated detoxifying enzyme genes expression and anti-oxidant induction". Oncogene 21 (34): 5301–12. Aug 2002. doi:10.1038/sj.onc.1205642. PMID 12149651.
- "Cytokine coexpression during human Th1/Th2 cell differentiation: direct evidence for coordinated expression of Th2 cytokines". Journal of Immunology 169 (5): 2498–506. Sep 2002. doi:10.4049/jimmunol.169.5.2498. PMID 12193719.
- "A new long form of c-Maf cooperates with Sox9 to activate the type II collagen gene". The Journal of Biological Chemistry 277 (52): 50668–75. Dec 2002. doi:10.1074/jbc.M206544200. PMID 12381733.
- "Analysis of non-crystallin lens fiber cell gene expression in c-Maf -/- mice". Molecular Vision 9: 288–94. Jun 2003. PMID 12835653.
- "Truncation of C-mip (Tc-mip), a new proximal signaling protein, induces c-maf Th2 transcription factor and cytoskeleton reorganization". The Journal of Experimental Medicine 198 (5): 797–807. Sep 2003. doi:10.1084/jem.20030566. PMID 12939343. PMC 1865475. http://www.hal.inserm.fr/inserm-00000005/document.
- "NF-kappa B p65 antagonizes IL-4 induction by c-maf in minimal change nephrotic syndrome". Journal of Immunology 172 (1): 688–98. Jan 2004. doi:10.4049/jimmunol.172.1.688. PMID 14688382.
- "C-MAF oncogene dysregulation in multiple myeloma: frequency and biological relevance". Leukemia & Lymphoma 44 (10): 1761–6. Oct 2003. doi:10.1080/1042819031000111035. PMID 14692531.
- "Overexpression of c-maf is a frequent oncogenic event in multiple myeloma that promotes proliferation and pathological interactions with bone marrow stroma". Cancer Cell 5 (2): 191–9. Feb 2004. doi:10.1016/S1535-6108(04)00019-4. PMID 14998494.
- "The protooncogene c-Maf is an essential transcription factor for IL-10 gene expression in macrophages". Journal of Immunology 174 (6): 3484–92. Mar 2005. doi:10.4049/jimmunol.174.6.3484. PMID 15749884.
- "Overexpression of c-Maf contributes to T-cell lymphoma in both mice and human". Cancer Research 66 (2): 812–9. Jan 2006. doi:10.1158/0008-5472.CAN-05-2154. PMID 16424013.
- "A novel mutation in the DNA-binding domain of MAF at 16q23.1 associated with autosomal dominant "cerulean cataract" in an Indian family". American Journal of Medical Genetics Part A 140 (6): 558–66. Mar 2006. doi:10.1002/ajmg.a.31126. PMID 16470690.
External links
- MAF+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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