Biology:NPAS1

From HandWiki
neuronal PAS domain protein 1
Identifiers
SymbolNPAS1
NCBI gene4861
HGNC7894
OMIM603346
RefSeqNM_002517
UniProtQ99742
Other data
LocusChr. 19 q13.2-13.3

NPAS1 is a basic helix-loop-helix transcription factor.[1][2] Npas1 is expressed in the developing forebrain in neuronal precursors of GABAergic projection neurons in the globus pallidus and basal forebrain as well as cortical and hippocampal interneurons[3][4][5][6]. Experiments in mice have linked neurons expressing Npas1 in the external globus pallidus to motor control[7][8] and those in the basal forebrain to sleep-wake control[9] and stress responsiveness[10]. Knockout and gene expression experiments have linked Npas1 to the control of behaviors and genes related to neuropsychiatric disorders [11][12]

See also

References

  1. ↑ "Molecular characterization of two mammalian bHLH-PAS domain proteins selectively expressed in the central nervous system". Proc. Natl. Acad. Sci. U.S.A. 94 (2): 713–8. January 1997. doi:10.1073/pnas.94.2.713. PMID 9012850. Bibcode: 1997PNAS...94..713Z. 
  2. ↑ "Characterization of a subset of the basic helix-loop-helix-PAS superfamily that interacts with components of the dioxin signaling pathway". J. Biol. Chem. 272 (13): 8581–93. March 1997. doi:10.1074/jbc.272.13.8581. PMID 9079689. 
  3. ↑ Cobos, Inma; Long, Jason E.; Thwin, Myo T.; Rubenstein, John L. (2006-07-01). "Cellular Patterns of Transcription Factor Expression in Developing Cortical Interneurons" (in en). Cerebral Cortex 16 (suppl_1): i82–i88. doi:10.1093/cercor/bhk003. ISSN 1460-2199. http://academic.oup.com/cercor/article/16/suppl_1/i82/270169/Cellular-Patterns-of-Transcription-Factor. 
  4. ↑ Flandin, Pierre; Kimura, Shioko; Rubenstein, John L. R. (2010-02-24). "The Progenitor Zone of the Ventral Medial Ganglionic Eminence Requires Nkx2-1 to Generate Most of the Globus Pallidus But Few Neocortical Interneurons" (in en). The Journal of Neuroscience 30 (8): 2812–2823. doi:10.1523/JNEUROSCI.4228-09.2010. ISSN 0270-6474. https://www.jneurosci.org/lookup/doi/10.1523/JNEUROSCI.4228-09.2010. 
  5. ↑ Nóbrega-Pereira, Sandrina; Gelman, Diego; Bartolini, Giorgia; Pla, Ramón; Pierani, Alessandra; Marín, Oscar (2010-02-24). "Origin and Molecular Specification of Globus Pallidus Neurons" (in en). The Journal of Neuroscience 30 (8): 2824–2834. doi:10.1523/JNEUROSCI.4023-09.2010. ISSN 0270-6474. https://www.jneurosci.org/lookup/doi/10.1523/JNEUROSCI.4023-09.2010. 
  6. ↑ Stanco, Amelia; Pla, Ramón; Vogt, Daniel; Chen, Yiran; Mandal, Shyamali; Walker, Jamie; Hunt, Robert; Lindtner, Susan et al. (3 Dec 2014). "NPAS1 Represses the Generation of Specific Subtypes of Cortical Interneurons" (in en). Neuron 84 (5): 940–953. doi:10.1016/j.neuron.2014.10.040. PMID 25467980. PMC 4258152. https://linkinghub.elsevier.com/retrieve/pii/S089662731400960X. 
  7. ↑ Hernandez, V. M.; Hegeman, D. J.; Cui, Q.; Kelver, D. A.; Fiske, M. P.; Glajch, K. E.; Pitt, J. E.; Huang, T. Y. et al. (2015-08-26). "Parvalbumin+ Neurons and Npas1+ Neurons Are Distinct Neuron Classes in the Mouse External Globus Pallidus" (in en). Journal of Neuroscience 35 (34): 11830–11847. doi:10.1523/JNEUROSCI.4672-14.2015. ISSN 0270-6474. https://www.jneurosci.org/lookup/doi/10.1523/JNEUROSCI.4672-14.2015. 
  8. ↑ Pamukcu, Arin; Cui, Qiaoling; Xenias, Harry S.; Berceau, Brianna L.; Augustine, Elizabeth C.; Fan, Isabel; Chalasani, Saivasudha; Hantman, Adam W. et al. (2020-10-07). "Parvalbumin + and Npas1 + Pallidal Neurons Have Distinct Circuit Topology and Function" (in en). The Journal of Neuroscience 40 (41): 7855–7876. doi:10.1523/JNEUROSCI.0361-20.2020. ISSN 0270-6474. https://www.jneurosci.org/lookup/doi/10.1523/JNEUROSCI.0361-20.2020. 
  9. ↑ Troppoli, Timothy A.; Yang, Chun; Katsuki, Fumi; Uygun, David S.; Lin, Ilyan; Aguilar, David D.; Spratt, Tristan; Basheer, Radhika et al. (2024-05-21). "Neuronal PAS domain 1 identifies a major subpopulation of wakefulness-promoting GABAergic neurons in the basal forebrain" (in en). Proceedings of the National Academy of Sciences 121 (21). doi:10.1073/pnas.2321410121. ISSN 0027-8424. PMID 38748575. PMC 11127008. https://pnas.org/doi/10.1073/pnas.2321410121. 
  10. ↑ Morais-Silva, Gessynger; Campbell, Rianne R.; Nam, Hyungwoo; Basu, Mahashweta; Pagliusi, Marco; Fox, Megan E.; Chan, C. Savio; Iñiguez, Sergio D. et al. (2023-01-18). "Molecular, Circuit, and Stress Response Characterization of Ventral Pallidum Npas1-Neurons" (in en). The Journal of Neuroscience 43 (3): 405–418. doi:10.1523/JNEUROSCI.0971-22.2022. ISSN 0270-6474. https://www.jneurosci.org/lookup/doi/10.1523/JNEUROSCI.0971-22.2022. 
  11. ↑ Erbel-Sieler, Claudia; Dudley, Carol; Zhou, Yudong; Wu, Xinle; Estill, Sandi Jo; Han, Tina; Diaz-Arrastia, Ramon; Brunskill, Eric W. et al. (2004-09-14). "Behavioral and regulatory abnormalities in mice deficient in the NPAS1 and NPAS3 transcription factors" (in en). Proceedings of the National Academy of Sciences 101 (37): 13648–13653. doi:10.1073/pnas.0405310101. ISSN 0027-8424. PMID 15347806. PMC 518807. https://pnas.org/doi/full/10.1073/pnas.0405310101. 
  12. ↑ Michaelson, Jacob J.; Shin, Min-Kyoo; Koh, Jin-Young; Brueggeman, Leo; Zhang, Angela; Katzman, Aaron; McDaniel, Latisha; Fang, Mimi et al. (2017). "Neuronal PAS Domain Proteins 1 and 3 Are Master Regulators of Neuropsychiatric Risk Genes" (in en). Biological Psychiatry 82 (3): 213–223. doi:10.1016/j.biopsych.2017.03.021. PMID 28499489. PMC 6901278. https://linkinghub.elsevier.com/retrieve/pii/S0006322317314609. 




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