Biology:CEBPE
From HandWiki
Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
CCAAT/enhancer binding protein (C/EBP), epsilon, also known as CEBPE and CRP1, is a type of ccaat-enhancer-binding protein. CEBPE is its human gene[1][2] and is pro-apoptotic.[3]
The protein encoded by this gene is a bZIP transcription factor which can bind as a homodimer to certain DNA regulatory regions. It can also form heterodimers with the related protein CEBP-δ. The encoded protein may be essential for terminal differentiation and functional maturation of committed granulocyte progenitor cells. Mutations in this gene have been associated with specific granule deficiency, a rare congenital disorder. Multiple variants of this gene have been described, but the full-length nature of only one has been determined.[1]
References
- ↑ 1.0 1.1 "Entrez Gene: CEBPE CCAAT/enhancer binding protein (C/EBP), epsilon". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1053.
- ↑ "A novel human CCAAT/enhancer binding protein gene, C/EBPepsilon, is expressed in cells of lymphoid and myeloid lineages and is localized on chromosome 14q11.2 close to the T-cell receptor alpha/delta locus". Genomics 35 (1): 30–8. Jul 1996. doi:10.1006/geno.1996.0319. PMID 8661101.
- ↑ "N-terminal region of CCAAT/enhancer-binding protein epsilon is critical for cell cycle arrest, apoptosis, and functional maturation during myeloid differentiation". The Journal of Biological Chemistry 281 (20): 14494–502. May 2006. doi:10.1074/jbc.M600575200. PMID 16531405.
Further reading
- "Mechanisms of liver-specific gene expression". Current Opinion in Genetics & Development 2 (2): 256–9. Apr 1992. doi:10.1016/S0959-437X(05)80282-5. PMID 1638120.
- "Neutrophil specific granule deficiency and mutations in the gene encoding transcription factor C/EBP(epsilon)". Current Opinion in Hematology 9 (1): 36–42. Jan 2002. doi:10.1097/00062752-200201000-00007. PMID 11753076.
- "A family of C/EBP-related proteins capable of forming covalently linked leucine zipper dimers in vitro". Genes & Development 5 (9): 1553–67. Sep 1991. doi:10.1101/gad.5.9.1553. PMID 1884998.
- "A novel human CCAAT/enhancer binding protein gene, C/EBPepsilon, is expressed in cells of lymphoid and myeloid lineages and is localized on chromosome 14q11.2 close to the T-cell receptor alpha/delta locus". Genomics 35 (1): 30–8. Jul 1996. doi:10.1006/geno.1996.0319. PMID 8661101.
- "Cloning of the novel human myeloid-cell-specific C/EBP-epsilon transcription factor". Molecular and Cellular Biology 17 (3): 1375–86. Mar 1997. doi:10.1128/mcb.17.3.1375. PMID 9032264.
- "CCAAT/enhancer binding protein epsilon is preferentially up-regulated during granulocytic differentiation and its functional versatility is determined by alternative use of promoters and differential splicing". Proceedings of the National Academy of Sciences of the United States of America 94 (12): 6462–7. Jun 1997. doi:10.1073/pnas.94.12.6462. PMID 9177240.
- "C/EBPepsilon directly interacts with the DNA binding domain of c-myb and cooperatively activates transcription of myeloid promoters". Blood 93 (10): 3327–37. May 1999. doi:10.1182/blood.V93.10.3327. PMID 10233885.
- "Neutrophil-specific granule deficiency results from a novel mutation with loss of function of the transcription factor CCAAT/enhancer binding protein epsilon". The Journal of Experimental Medicine 189 (11): 1847–52. Jun 1999. doi:10.1084/jem.189.11.1847. PMID 10359588.
- "Macrophage functional maturation and cytokine production are impaired in C/EBP epsilon-deficient mice". Blood 99 (5): 1794–801. Mar 2002. doi:10.1182/blood.V99.5.1794. PMID 11861297.
- "Induction of granulocytic differentiation by 2 pathways". Blood 99 (12): 4406–12. Jun 2002. doi:10.1182/blood.V99.12.4406. PMID 12036869.
- "Transcriptional activity of CCAAT/enhancer-binding proteins is controlled by a conserved inhibitory domain that is a target for sumoylation". The Journal of Biological Chemistry 277 (41): 38037–44. Oct 2002. doi:10.1074/jbc.M207235200. PMID 12161447.
- "Novel combinatorial interactions of GATA-1, PU.1, and C/EBPepsilon isoforms regulate transcription of the gene encoding eosinophil granule major basic protein". The Journal of Biological Chemistry 277 (45): 43481–94. Nov 2002. doi:10.1074/jbc.M204777200. PMID 12202480.
- "CCAAT/Enhancer binding proteins repress the leukemic phenotype of acute myeloid leukemia". Blood 101 (3): 1141–8. Feb 2003. doi:10.1182/blood-2002-05-1374. PMID 12393450.
- "Regulation of neutrophil and eosinophil secondary granule gene expression by transcription factors C/EBP epsilon and PU.1". Blood 101 (8): 3265–73. Apr 2003. doi:10.1182/blood-2002-04-1039. PMID 12515729.
- "Chromatin immunoprecipitation (ChIP) studies indicate a role for CCAAT enhancer binding proteins alpha and epsilon (C/EBP alpha and C/EBP epsilon ) and CDP/cut in myeloid maturation-induced lactoferrin gene expression". Blood 101 (9): 3460–8. May 2003. doi:10.1182/blood-2002-09-2767. PMID 12522000.
- "C/EBPepsilon interacts with retinoblastoma and E2F1 during granulopoiesis". Blood 103 (3): 828–35. Feb 2004. doi:10.1182/blood-2003-01-0159. PMID 12947005.
- "Retinoic acid regulates C/EBP homologous protein expression (CHOP), which negatively regulates myeloid target genes". Blood 104 (13): 3911–7. Dec 2004. doi:10.1182/blood-2003-10-3688. PMID 15308577.
External links
- CEBPE protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)
- Human CEBPE genome location and CEBPE gene details page in the UCSC Genome Browser.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
 |  |
