Biology:BHLHB2
From HandWiki
Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Class E basic helix-loop-helix protein 40 is a protein that in humans is encoded by the BHLHE40 gene.[1][2][3][4]
Function
DEC1 encodes a basic helix-loop-helix protein expressed in various tissues. Expression in the chondrocytes is responsive to the addition of Bt2cAMP. Differentiated embryo chondrocyte expressed gene 1 is believed to be involved in the control of cell differentiation.[4]
References
- ↑ "Molecular characterization of the novel basic helix-loop-helix protein DEC1 expressed in differentiated human embryo chondrocytes". Biochemical and Biophysical Research Communications 236 (2): 294–8. Jul 1997. doi:10.1006/bbrc.1997.6960. PMID 9240428.
- ↑ "Assignment1 of the human Stra13 gene (STRA13) to chromosome 3p26 by in situ hybridization". Cytogenetics and Cell Genetics 85 (3–4): 254–5. Oct 1999. doi:10.1159/000015305. PMID 10449910.
- ↑ "Phylogenetic and expression analysis of the basic helix-loop-helix transcription factor gene family: genomic approach to cellular differentiation". Differentiation; Research in Biological Diversity 76 (9): 1006–22. Nov 2008. doi:10.1111/j.1432-0436.2008.00285.x. PMID 18557763.
- ↑ 4.0 4.1 "Entrez Gene: BHLHB2 basic helix-loop-helix domain containing, class B, 2". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8553.
Further reading
- "Gene structure and chromosomal location of a human bHLH transcriptional factor DEC1 x Stra13 x SHARP-2/BHLHB2". Journal of Biochemistry 129 (3): 391–6. Mar 2001. doi:10.1093/oxfordjournals.jbchem.a002869. PMID 11226878.
- "Regulation of STRA13 by the von Hippel-Lindau tumor suppressor protein, hypoxia, and the UBC9/ubiquitin proteasome degradation pathway". The Journal of Biological Chemistry 276 (18): 15306–15. May 2001. doi:10.1074/jbc.M010516200. PMID 11278694.
- "Defective T cell activation and autoimmune disorder in Stra13-deficient mice". Nature Immunology 2 (11): 1040–7. Nov 2001. doi:10.1038/ni721. PMID 11668339.
- "Identification of genes differentially induced by hypoxia in pancreatic cancer cells". Biochemical and Biophysical Research Communications 288 (4): 882–6. Nov 2001. doi:10.1006/bbrc.2001.5867. PMID 11688991.
- "Abundant expression of Dec1/stra13/sharp2 in colon carcinoma: its antagonizing role in serum deprivation-induced apoptosis and selective inhibition of procaspase activation". The Biochemical Journal 367 (Pt 2): 413–22. Oct 2002. doi:10.1042/BJ20020514. PMID 12119049.
- "Stra13 homodimers repress transcription through class B E-box elements". The Journal of Biological Chemistry 277 (48): 46544–51. Nov 2002. doi:10.1074/jbc.M111652200. PMID 12297495.
- "Identification of functional hypoxia response elements in the promoter region of the DEC1 and DEC2 genes". The Journal of Biological Chemistry 277 (49): 47014–21. Dec 2002. doi:10.1074/jbc.M204938200. PMID 12354771.
- "Basic helix-loop-helix protein DEC1 promotes chondrocyte differentiation at the early and terminal stages". The Journal of Biological Chemistry 277 (51): 50112–20. Dec 2002. doi:10.1074/jbc.M206771200. PMID 12384505.
- "Dec1 and Dec2 are regulators of the mammalian molecular clock". Nature 419 (6909): 841–4. Oct 2002. doi:10.1038/nature01123. PMID 12397359. Bibcode: 2002Natur.419..841H.
- "DEC1 negatively regulates the expression of DEC2 through binding to the E-box in the proximal promoter". The Journal of Biological Chemistry 278 (19): 16899–907. May 2003. doi:10.1074/jbc.M300596200. PMID 12624110.
- "DEC1 (STRA13) protein expression relates to hypoxia- inducible factor 1-alpha and carbonic anhydrase-9 overexpression in non-small cell lung cancer". The Journal of Pathology 200 (2): 222–8. Jun 2003. doi:10.1002/path.1330. PMID 12754744.
- "STRA13 interacts with STAT3 and modulates transcription of STAT3-dependent targets". Journal of Molecular Biology 340 (4): 641–53. Jul 2004. doi:10.1016/j.jmb.2004.05.025. PMID 15223310.
- "Functional analysis of the basic helix-loop-helix transcription factor DEC1 in circadian regulation. Interaction with BMAL1". European Journal of Biochemistry 271 (22): 4409–19. Nov 2004. doi:10.1111/j.1432-1033.2004.04379.x. PMID 15560782.
- "Association, mutual stabilization, and transcriptional activity of the STRA13 and MSP58 proteins". Cellular and Molecular Life Sciences 62 (4): 471–84. Feb 2005. doi:10.1007/s00018-004-4423-2. PMID 15719173. https://zenodo.org/record/1232585.
- "STRA13 expression and subcellular localisation in normal and tumour tissues: implications for use as a diagnostic and differentiation marker". Journal of Medical Genetics 42 (7): 565–76. Jul 2005. doi:10.1136/jmg.2004.029835. PMID 15994878.
- "A human protein-protein interaction network: a resource for annotating the proteome". Cell 122 (6): 957–68. Sep 2005. doi:10.1016/j.cell.2005.08.029. PMID 16169070.
External links
- BHLHB2+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
- FactorBook BHLHE40
- Human BHLHE40 genome location and BHLHE40 gene details page in the UCSC Genome Browser.
- Human DEC1 genome location and DEC1 gene details page in the UCSC Genome Browser.
- Human STRA13 genome location and STRA13 gene details page in the UCSC Genome Browser.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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