Biology:HIVEP3
 Generic protein structure example |
Transcription factor HIVEP3 is a protein that in humans is encoded by the HIVEP3 gene.[1][2]
Function
Members of the ZAS family, such as ZAS3 (HIVEP3), are large proteins that contain a ZAS domain, a modular protein structure consisting of a pair of C2H2 zinc fingers with an acidic-rich region and a serine/threonine -rich sequence. These proteins bind specific DNA sequences, including the kappa-B motif (GGGACTTTCC), in the promoters and enhancer regions of several genes and viruses, including human immunodeficiency virus (HIV). ZAS genes span more than 150 kb and contain at least 10 exons, one of which is longer than 5.5 kb (Allen and Wu, 2004).[supplied by OMIM][2]
It regulates osteoblasts.[3]
Interactions
HIVEP3 has been shown to interact with TRAF1[4] and TRAF2.[4]
References
- ↑ "Structure of the human zinc finger protein HIVEP3: molecular cloning, expression, exon-intron structure, and comparison with paralogous genes HIVEP1 and HIVEP2". Genomics 71 (1): 89–100. Jan 2001. doi:10.1006/geno.2000.6425. PMID 11161801.
- ↑ 2.0 2.1 "Entrez Gene: HIVEP3 human immunodeficiency virus type I enhancer binding protein 3". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=59269.
- ↑ Glimcher, LH; Jones, DC; Wein, MN (November 2007). "Control of postnatal bone mass by the zinc finger adapter protein Schnurri-3.". Annals of the New York Academy of Sciences 1116 (1): 174–81. doi:10.1196/annals.1402.044. PMID 18083927. Bibcode: 2007NYASA1116..174G.
- ↑ 4.0 4.1 "A mammalian homolog of Drosophila schnurri, KRC, regulates TNF receptor-driven responses and interacts with TRAF2". Molecular Cell 9 (1): 121–31. Jan 2002. doi:10.1016/S1097-2765(01)00434-8. PMID 11804591.
Further reading
- "Two genes encode factors with NF-kappa B- and H2TF1-like DNA-binding properties". Proceedings of the National Academy of Sciences of the United States of America 87 (22): 8707–10. Nov 1990. doi:10.1073/pnas.87.22.8707. PMID 2247438. Bibcode: 1990PNAS...87.8707R.
- "Prediction of the coding sequences of unidentified human genes. XVIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research 7 (4): 273–81. Aug 2000. doi:10.1093/dnares/7.4.271. PMID 10997877.
- "A mammalian homolog of Drosophila schnurri, KRC, regulates TNF receptor-driven responses and interacts with TRAF2". Molecular Cell 9 (1): 121–31. Jan 2002. doi:10.1016/S1097-2765(01)00434-8. PMID 11804591.
- "Schnurri-3 (KRC) interacts with c-Jun to regulate the IL-2 gene in T cells". The Journal of Experimental Medicine 199 (1): 15–24. Jan 2004. doi:10.1084/jem.20030421. PMID 14707112.
- "RING1 inhibits transactivation of RBP-J by Notch through interaction with LIM protein KyoT2". Nucleic Acids Research 32 (4): 1492–501. 2004. doi:10.1093/nar/gkh295. PMID 14999091.
- "Structural characterization of the gene encoding the large zinc finger protein ZAS3: implication to the origin of multiple promoters in eukaryotic genes". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression 1681 (2–3): 74–87. Jan 2005. doi:10.1016/j.bbaexp.2004.10.004. PMID 15627499.
- "Foxp3 interacts with nuclear factor of activated T cells and NF-kappa B to repress cytokine gene expression and effector functions of T helper cells". Proceedings of the National Academy of Sciences of the United States of America 102 (14): 5138–43. Apr 2005. doi:10.1073/pnas.0501675102. PMID 15790681. Bibcode: 2005PNAS..102.5138B.
- "Investigation of the PARK10 gene in Parkinson disease". Annals of Human Genetics 71 (Pt 5): 639–47. Sep 2007. doi:10.1111/j.1469-1809.2007.00353.x. PMID 17388942.
External links
- HIVEP3+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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