Biology:Transcription factor II E
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Short description: Transcription factor
| general transcription factor IIE, polypeptide 1, alpha 56kDa | |
|---|---|
| Identifiers | |
| Symbol | GTF2E1 |
| Alt. symbols | TF2E1 |
| NCBI gene | 2960 |
| HGNC | 4650 |
| OMIM | 189962 |
| RefSeq | NM_005513 |
| UniProt | P29083 |
| Other data | |
| Locus | Chr. 3 q21-q24 |
| general transcription factor IIE, polypeptide 2, beta 34kDa | |
|---|---|
| Identifiers | |
| Symbol | GTF2E2 |
| Alt. symbols | TF2E2 |
| NCBI gene | 2961 |
| HGNC | 4651 |
| OMIM | 189964 |
| RefSeq | NM_002095 |
| UniProt | P29084 |
| Other data | |
| Locus | Chr. 8 p12 |
Transcription factor II E (TFIIE) is one of several general transcription factors that make up the RNA polymerase II preinitiation complex.[1] It is a tetramer of two alpha and two beta chains and interacts with TAF6/TAFII80, ATF7IP, and varicella-zoster virus IE63 protein.[2]
TFIIE recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase.[2] Transcription factor II E is encoded by the GTF2E1 and GTF2E2 genes.[3][4][5][6] TFIIE is thought to be involved in DNA melting at the promoter: it contains a zinc ribbon motif that can bind single stranded DNA.[7]
See also
References
- ↑ Lewin, Benjamin (2004). Genes VIII. Upper Saddle River, NJ: Pearson Prentice Hall. pp. 636–637. ISBN 0-13-144946-X. https://archive.org/details/genesviii00lewi.
- ↑ 2.0 2.1 "UniProtKB - P29083 (T2EA_HUMAN)". https://www.uniprot.org/uniprot/P29083.
- ↑ "Identification of two large subdomains in TFIIE-alpha on the basis of homology between Xenopus and human sequences". Nucleic Acids Res. 20 (21): 5838. 1992. doi:10.1093/nar/20.21.5838. PMID 1454543.
- ↑ "Genes encoding general initiation factors for RNA polymerase II transcription are dispersed in the human genome". Hum. Mol. Genet. 3 (1): 61–4. 1994. doi:10.1093/hmg/3.1.61. PMID 8162052.
- ↑ "Conserved sequence motifs in the small subunit of human general transcription factor TFIIE". Nature 354 (6352): 401–4. 1991. doi:10.1038/354401a0. PMID 1956404. Bibcode: 1991Natur.354..401S.
- ↑ "Structural motifs and potential sigma homologies in the large subunit of human general transcription factor TFIIE". Nature 354 (6352): 398–401. December 1991. doi:10.1038/354398a0. PMID 1956403.
- ↑ "Transcription of eukaryotic protein-coding genes". Annu. Rev. Genet. 34: 77–137. 2000. doi:10.1146/annurev.genet.34.1.77. PMID 11092823.
External links
- Transcription+Factor+TFIIE at the US National Library of Medicine Medical Subject Headings (MeSH)
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