Biology:SOX8
From HandWiki
Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Transcription factor SOX-8 is a protein that in humans is encoded by the SOX8 gene.[1][2][3]
This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional activator after forming a protein complex with other proteins. This protein may be involved in brain development and function. Haploinsufficiency for this protein may contribute to the mental retardation found in haemoglobin H-related mental retardation (ATR-16 syndrome).[3]
See also
- SOX genes
References
- ↑ "The SOX8 gene is located within 700 kb of the tip of chromosome 16p and is deleted in a patient with ATR-16 syndrome". Genomics 63 (1): 108–16. Apr 2000. doi:10.1006/geno.1999.6060. PMID 10662550.
- ↑ "Cloning and characterisation of the Sry-related transcription factor gene Sox8". Nucleic Acids Res 28 (6): 1473–80. Apr 2000. doi:10.1093/nar/28.6.1473. PMID 10684944.
- ↑ 3.0 3.1 "Entrez Gene: SOX8 SRY (sex determining region Y)-box 8". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=30812.
Further reading
- "Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16". Hum. Mol. Genet. 10 (4): 339–52. 2001. doi:10.1093/hmg/10.4.339. PMID 11157797.
- "Sox8 gene expression identifies immature glial cells in developing cerebellum and cerebellar tumours". Brain Res. Mol. Brain Res. 92 (1–2): 193–200. 2001. doi:10.1016/S0169-328X(01)00147-4. PMID 11483257.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides". Nat. Biotechnol. 21 (5): 566–9. 2004. doi:10.1038/nbt810. PMID 12665801.
- "SOX8 is expressed during testis differentiation in mice and synergizes with SF1 to activate the Amh promoter in vitro". J. Biol. Chem. 278 (30): 28101–8. 2003. doi:10.1074/jbc.M304067200. PMID 12732652.
- "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. 2004. doi:10.1038/ng1285. PMID 14702039.
- "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334.
- "The sequence and analysis of duplication-rich human chromosome 16". Nature 432 (7020): 988–94. 2005. doi:10.1038/nature03187. PMID 15616553. Bibcode: 2004Natur.432..988M. https://digital.library.unt.edu/ark:/67531/metadc788092/m2/1/high_res_d/842679.pdf.
- "The high-mobility-group domain of Sox proteins interacts with DNA-binding domains of many transcription factors". Nucleic Acids Res. 34 (6): 1735–44. 2006. doi:10.1093/nar/gkl105. PMID 16582099.
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