Biology:Y box binding protein 1

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Short description: Protein-coding gene in the species Homo sapiens

A representation of the 3D structure of the protein myoglobin showing turquoise α-helices.
Generic protein structure example

Y box binding protein 1 also known as Y-box transcription factor or nuclease-sensitive element-binding protein 1 is a protein that in humans is encoded by the YBX1 gene.[1] YBX1 is an RNA binding protein[2] that stabilises messenger RNAs modified with N6-methyladenosine.[3]

Clinical significance

YBX1 is a potential drug target in cancer therapy.[4] YB-1 helps the replication of adenovirus type 5, a commonly used vector in gene therapy.[4] Thus, YB-1 can cause an "oncolytic" effect in YB-1 positive cancer cells treated with adenoviruses.

DNA repair

The mitochondria of human cells possess a repair pathway for DNA base pair mismatches that is distinct from the DNA mismatch repair pathway of the nucleus.[5] This mitochondrial pathway includes participation of Y box binding protein 1 (designated YB-1 or YBX1), that likely acts in the mismatch binding and recognition steps of mismatch repair.[5]

Interactions

Y box binding protein 1 has been shown to interact with:

References

  1. ↑ EntrezGene 4904 YBX1 Y-box binding protein 1
  2. ↑ "The RNA-binding protein YBX1 regulates epidermal progenitors at a posttranscriptional level". Nature Communications 9 (1). April 2018. doi:10.1038/s41467-018-04092-0. PMID 29712925. Bibcode: 2018NatCo...9.1734K. 
  3. ↑ "YBX1 is required for maintaining myeloid leukemia cell survival by regulating BCL2 stability in an m6A-dependent manner". Blood 138 (1): 71–85. July 2021. doi:10.1182/blood.2020009676. PMID 33763698. 
  4. ↑ 4.0 4.1 "[YB-1 as a potential target in cancer therapy]" (in de). Der Pathologe 29 (Suppl 2): 187–190. November 2008. doi:10.1007/s00292-008-1030-2. PMID 18773210. 
  5. ↑ 5.0 5.1 "Novel DNA mismatch-repair activity involving YB-1 in human mitochondria". DNA Repair (Amst) 8 (6): 704–19. 2009. doi:10.1016/j.dnarep.2009.01.021. PMID 19272840. 
  6. ↑ 6.0 6.1 "The Ankrd2 protein, a link between the sarcomere and the nucleus in skeletal muscle". Journal of Molecular Biology 339 (2): 313–325. May 2004. doi:10.1016/j.jmb.2004.03.071. PMID 15136035. 
  7. ↑ "Physical and functional interaction between two pluripotent proteins, the Y-box DNA/RNA-binding factor, YB-1, and the multivalent zinc finger factor, CTCF". The Journal of Biological Chemistry 275 (38): 29915–29921. September 2000. doi:10.1074/jbc.M001538200. PMID 10906122. 
  8. ↑ "Direct interaction of p53 with the Y-box binding protein, YB-1: a mechanism for regulation of human gene expression". Oncogene 19 (54): 6194–6202. December 2000. doi:10.1038/sj.onc.1204029. PMID 11175333. 
  9. ↑ "Transcription factor Y-box binding protein 1 binds preferentially to cisplatin-modified DNA and interacts with proliferating cell nuclear antigen". Cancer Research 59 (2): 342–346. January 1999. PMID 9927044. 
  10. ↑ "RBBP6 interacts with multifunctional protein YB-1 through its RING finger domain, leading to ubiquitination and proteosomal degradation of YB-1". Journal of Molecular Biology 384 (4): 908–916. December 2008. doi:10.1016/j.jmb.2008.09.060. PMID 18851979. 
  11. ↑ "Splicing factor SRp30c interaction with Y-box protein-1 confers nuclear YB-1 shuttling and alternative splice site selection". The Journal of Biological Chemistry 278 (20): 18241–18248. May 2003. doi:10.1074/jbc.M212518200. PMID 12604611. 

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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