Biology:Y box binding protein 1

Short description: Protein-coding gene in the species Homo sapiens

Generic protein structure example

Y box binding protein 1 also known as Y-box transcription factor or nuclease-sensitive element-binding protein 1 is a protein that in humans is encoded by the YBX1 gene.

Clinical significance

YBX1 is a potential drug target in cancer therapy. YB-1 helps the replication of adenovirus type 5, a commonly used vector in gene therapy. Thus, YB-1 can cause an "oncolytic" effect in YB-1 positive cancer cells treated with adenoviruses.

Interactions

Y box binding protein 1 has been shown to interact with:

• ANKRD2,
• CTCF,
• P53,
• PCNA,
• RBBP6, and
• SFRS9.

Further reading

• "A CT promoter element binding protein: definition of a double-strand and a novel single-strand DNA binding motif.". Nucleic Acids Res. 20 (1): 111–6. 1992. doi:10.1093/nar/20.1.111. PMID 1738588. 
• "Full length cDNA sequence encoding a nuclease-sensitive element DNA binding protein.". Nucleic Acids Res. 19 (17): 4771. 1991. doi:10.1093/nar/19.17.4771. PMID 1891370. 
• "Two human genes isolated by a novel method encode DNA-binding proteins containing a common region of homology.". Gene 73 (2): 499–507. 1989. doi:10.1016/0378-1119(88)90514-8. PMID 2977358. 
• "Characterization of the cDNA encoding a protein binding to the major histocompatibility complex class II Y box.". Proc. Natl. Acad. Sci. U.S.A. 85 (19): 7322–6. 1988. doi:10.1073/pnas.85.19.7322. PMID 3174636. Bibcode: 1988PNAS...85.7322D. 
• "Characterization of the gene for dbpA, a family member of the nucleic-acid-binding proteins containing a cold-shock domain.". Eur. J. Biochem. 231 (1): 72–82. 1995. doi:10.1111/j.1432-1033.1995.tb20672.x. PMID 7628487. 
• "Repression of major histocompatibility complex I-A beta gene expression by dbpA and dbpB (mYB-1) proteins.". Mol. Cell. Biol. 15 (9): 5092–9. 1995. doi:10.1128/mcb.15.9.5092. PMID 7651426. 
• "Cooperative action of cellular proteins YB-1 and Pur alpha with the tumor antigen of the human JC polyomavirus determines their interaction with the viral lytic control element.". Proc. Natl. Acad. Sci. U.S.A. 92 (4): 1087–91. 1995. doi:10.1073/pnas.92.4.1087. PMID 7862639. Bibcode: 1995PNAS...92.1087C. 
• "A human protein containing a "cold shock" domain binds specifically to H-DNA upstream from the human gamma-globin genes.". J. Biol. Chem. 269 (19): 14130–9. 1994. doi:10.1016/S0021-9258(17)36764-9. PMID 8188694. 
• "Involvement of transcription factor YB-1 in human T-cell lymphotropic virus type I basal gene expression.". J. Virol. 68 (1): 561–5. 1994. doi:10.1128/JVI.68.1.561-565.1994. PMID 8254772. 
• "Structural and functional analysis of the human Y-box binding protein (YB-1) gene promoter.". Nucleic Acids Res. 24 (10): 1873–8. 1996. doi:10.1093/nar/24.10.1873. PMID 8657568. 
• "The mouse poly(C)-binding protein exists in multiple isoforms and interacts with several RNA-binding proteins.". Nucleic Acids Res. 24 (19): 3821–8. 1996. doi:10.1093/nar/24.19.3821. PMID 8871564. 
• "Nuclear translocation of the Y-box binding protein by ultraviolet irradiation.". FEBS Lett. 417 (3): 390–4. 1998. doi:10.1016/S0014-5793(97)01296-9. PMID 9409758. 
• "Genomic organization of the human Y-box protein (YB-1) gene.". Gene 206 (1): 93–7. 1998. doi:10.1016/S0378-1119(97)00570-2. PMID 9461420. 
• "Transcription of the human immunodeficiency virus type 1 (HIV-1) promoter in central nervous system cells: effect of YB-1 on expression of the HIV-1 long terminal repeat.". J. Gen. Virol.. 79 ( Pt 2) (2): 239–46. 1998. doi:10.1099/0022-1317-79-2-239. PMID 9472608. 
• "A synergistic interaction of transcription factors AP2 and YB-1 regulates gelatinase A enhancer-dependent transcription.". J. Biol. Chem. 273 (49): 32957–65. 1999. doi:10.1074/jbc.273.49.32957. PMID 9830047. 
• "Transcription factor Y-box binding protein 1 binds preferentially to cisplatin-modified DNA and interacts with proliferating cell nuclear antigen.". Cancer Res. 59 (2): 342–6. 1999. PMID 9927044. 
• "Reciprocal interaction between two cellular proteins, Puralpha and YB-1, modulates transcriptional activity of JCVCY in glial cells.". Mol. Cell. Biol. 19 (4): 2712–23. 1999. doi:10.1128/mcb.19.4.2712. PMID 10082537. 
• "Molecular interactions between single-stranded DNA-binding proteins associated with an essential MCAT element in the mouse smooth muscle alpha-actin promoter.". J. Biol. Chem. 274 (20): 14238–45. 1999. doi:10.1074/jbc.274.20.14238. PMID 10318844. 
• "Physical and functional interaction between the Y-box binding protein YB-1 and human polyomavirus JC virus large T antigen.". J. Virol. 73 (12): 10146–57. 1999. doi:10.1128/JVI.73.12.10146-10157.1999. PMID 10559330. 
• "Interaction of YB-1 with human immunodeficiency virus type 1 Tat and TAR RNA modulates viral promoter activity.". J. Gen. Virol.. 80 ( Pt 10) (10): 2629–38. 1999. doi:10.1099/0022-1317-80-10-2629. PMID 10573156. 
• "Akt-dependent nuclear localization of Y-box-binding protein 1 in acquisition of malignant characteristics by human ovarian cancer cells.". Oncogene 26 (19): 2736–46. 2007. doi:10.1038/sj.onc.1210084. PMID 17072343. 

External links

• YBX1+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.