Biology:Retinoid X receptor gamma

Short description: Protein-coding gene in the species Homo sapiens

Generic protein structure example

Retinoid X receptor gamma (RXR-gamma), also known as NR2B3 (nuclear receptor subfamily 2, group B, member 3) is a nuclear receptor that in humans is encoded by the RXRG gene.

Function

This gene encodes a member of the retinoid X receptor (RXR) family of nuclear receptors which are involved in mediating the antiproliferative effects of retinoic acid (RA). This receptor forms heterodimers with the retinoic acid, thyroid hormone, and vitamin D receptors, increasing both DNA binding and transcriptional function on their respective response elements. This gene is expressed at significantly lower levels in non-small cell lung cancer cells. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

See also

• Retinoid X receptor

Interactions

Retinoid X receptor gamma has been shown to interact with ITGB3BP.

Further reading

• "Retinoid X receptors: X-ploring their (patho)physiological functions.". Cell Death Differ. 11 Suppl 2 (S2): S126–43. 2005. doi:10.1038/sj.cdd.4401533. PMID 15608692. 
• "Purification, cloning, and RXR identity of the HeLa cell factor with which RAR or TR heterodimerizes to bind target sequences efficiently.". Cell 68 (2): 377–95. 1992. doi:10.1016/0092-8674(92)90478-U. PMID 1310259. 
• "Characterization of three RXR genes that mediate the action of 9-cis retinoic acid.". Genes Dev. 6 (3): 329–44. 1992. doi:10.1101/gad.6.3.329. PMID 1312497. 
• "Physical mapping of the retinoid X receptor B gene in mouse and human.". Immunogenetics 41 (2–3): 83–90. 1995. doi:10.1007/BF00182317. PMID 7806300. 
• "Activation of myoD gene transcription by 3,5,3'-triiodo-L-thyronine: a direct role for the thyroid hormone and retinoid X receptors". Nucleic Acids Res. 22 (4): 583–91. 1994. doi:10.1093/nar/22.4.583. PMID 8127707. 
• "A CBP integrator complex mediates transcriptional activation and AP-1 inhibition by nuclear receptors". Cell 85 (3): 403–14. 1996. doi:10.1016/S0092-8674(00)81118-6. PMID 8616895. 
• "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. 1997. doi:10.1101/gr.6.9.791. PMID 8889548. 
• "Immunohistochemical expression of retinoid X receptor isoforms in human pituitaries and pituitary adenomas". Neuroendocrinology 65 (4): 299–306. 1997. doi:10.1159/000127188. PMID 9143002. 
• "Expression of retinoid-X receptors (-alpha,-beta,-gamma) and retinoic acid receptors (-alpha,-beta,-gamma) in normal human skin: an immunohistological evaluation". Histochem. J. 29 (2): 127–33. 1997. doi:10.1023/A:1026481205135. PMID 9147069. 
• "Suppression of retinoic acid receptor beta in non-small-cell lung cancer in vivo: implications for lung cancer development". J. Natl. Cancer Inst. 89 (9): 624–9. 1997. doi:10.1093/jnci/89.9.624. PMID 9150186. 
• "The thyrotropin beta-subunit gene is repressed by thyroid hormone in a novel thyrotrope cell line, mouse T alphaT1 cells". Endocrinology 139 (11): 4476–82. 1998. doi:10.1210/endo.139.11.6283. PMID 9794455. 
• "Retinoid receptors in the human endometrium and its disorders: a possible modulator of 17 beta-hydroxysteroid dehydrogenase". J. Clin. Endocrinol. Metab. 86 (6): 2721–7. 2001. doi:10.1210/jcem.86.6.7546. PMID 11397877. 
• "Retinoid-dependent antagonism of serum response factor transactivation mediated by transcriptional coactivator proteins". Oncogene 20 (45): 6638–42. 2001. doi:10.1038/sj.onc.1204695. PMID 11641790. 
• "The role of retinoid X receptor messenger RNA expression in curatively resected non-small cell lung cancer". Clin. Cancer Res. 8 (2): 438–43. 2002. PMID 11839661. 
• "The activation function-1 domain of Nur77/NR4A1 mediates trans-activation, cell specificity, and coactivator recruitment". J. Biol. Chem. 277 (36): 33001–11. 2002. doi:10.1074/jbc.M203572200. PMID 12082103. 
• "Expression of PPAR and RXR isoforms in the developing rat and human term placentas". Placenta 23 (8–9): 661–71. 2003. doi:10.1053/plac.2002.0855. PMID 12361685. 
• "Retinoid receptors in the developing human lung". Clin. Sci. 103 (6): 613–21. 2003. doi:10.1042/cs1030613. PMID 12444914. 
• "Immunohistochemical detection of the retinoid X receptors alpha, beta, and gamma in human prostate". J. Androl. 24 (1): 113–9. 2003. doi:10.1002/j.1939-4640.2003.tb02649.x. PMID 12514092. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.