Biology:HOXD11
 Generic protein structure example |
Homeobox protein Hox-D11 is a protein that in humans is encoded by the HOXD11 gene.[1][2][3]
This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXD genes located in a cluster on chromosome 2. Deletions that remove the entire HOXD gene cluster or the 5' end of this cluster have been associated with severe limb and genital abnormalities. The product of the mouse Hoxd11 gene plays a role in axial skeleton development and forelimb morphogenesis.[3][4][5][6]
See also
References
- ↑ "Nomenclature for human homeobox genes". Genomics 7 (3): 460. August 1990. doi:10.1016/0888-7543(90)90186-X. PMID 1973146.
- ↑ Scott MP (December 1992). "Vertebrate homeobox gene nomenclature". Cell 71 (4): 551–3. doi:10.1016/0092-8674(92)90588-4. PMID 1358459.
- ↑ 3.0 3.1 "HOXD11 homeobox D11". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3237.
- ↑ "Axial homeosis and appendicular skeleton defects in mice with a targeted disruption of hoxd-11". Development 120 (8): 2187–98. 1 August 1994. doi:10.1242/dev.120.8.2187. PMID 7925020. http://dev.biologists.org/cgi/pmidlookup?view=long&pmid=7925020.
- ↑ "Absence of radius and ulna in mice lacking hoxa-11 and hoxd-11". Nature 375 (6534): 791–5. June 1995. doi:10.1038/375791a0. PMID 7596412. Bibcode: 1995Natur.375..791D.
- ↑ "A mutational analysis of the 5' HoxD genes: dissection of genetic interactions during limb development in the mouse". Development 122 (4): 1175–85. 1 April 1996. doi:10.1242/dev.122.4.1175. PMID 8620844. http://dev.biologists.org/cgi/pmidlookup?view=long&pmid=8620844.
Further reading
- "Molecular models for vertebrate limb development". Cell 90 (6): 979–90. 1997. doi:10.1016/S0092-8674(00)80364-5. PMID 9323126.
- Goodman FR (2003). "Limb malformations and the human HOX genes". Am. J. Med. Genet. 112 (3): 256–65. doi:10.1002/ajmg.10776. PMID 12357469.
- "The human HOX gene family". Nucleic Acids Res. 17 (24): 10385–402. 1990. doi:10.1093/nar/17.24.10385. PMID 2574852.
- "AbdB-like Hox proteins stabilize DNA binding by the Meis1 homeodomain proteins". Mol. Cell. Biol. 17 (11): 6448–58. 1997. doi:10.1128/MCB.17.11.6448. PMID 9343407.
- "Hox gene expression in limbs: colinearity by opposite regulatory controls". Dev. Biol. 208 (1): 157–65. 1999. doi:10.1006/dbio.1998.9179. PMID 10075849.
- "Monodactylous limbs and abnormal genitalia are associated with hemizygosity for the human 2q31 region that includes the HOXD cluster". Am. J. Hum. Genet. 65 (1): 104–10. 1999. doi:10.1086/302467. PMID 10364522.
- "Clustering of two fragile sites and seven homeobox genes in human chromosome region 2q31→q32.1". Cytogenet. Cell Genet. 90 (1–2): 151–3. 2000. doi:10.1159/000015651. PMID 11060466.
- "Hoxa11 and Hoxd11 regulate branching morphogenesis of the ureteric bud in the developing kidney". Development 128 (11): 2153–61. 2001. doi:10.1242/dev.128.11.2153. PMID 11493536.
- "A 117-kb Microdeletion Removing HOXD9–HOXD13 and EVX2 Causes Synpolydactyly". Am. J. Hum. Genet. 70 (2): 547–55. 2002. doi:10.1086/338921. PMID 11778160.
- "The HOXD11 gene is fused to the NUP98 gene in acute myeloid leukemia with t(2;11)(q31;p15)". Cancer Res. 62 (1): 33–7. 2002. PMID 11782354.
- "Complete mutation analysis panel of the 39 human HOX genes". Teratology 65 (2): 50–62. 2002. doi:10.1002/tera.10009. PMID 11857506.
- "Duplication of the Hoxd11 gene causes alterations in the axial and appendicular skeleton of the mouse". Dev. Biol. 249 (1): 96–107. 2002. doi:10.1006/dbio.2002.0755. PMID 12217321.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "Mutations in HOXD13 Underlie Syndactyly Type V and a Novel Brachydactyly-Syndactyly Syndrome". Am. J. Hum. Genet. 80 (2): 361–71. 2007. doi:10.1086/511387. PMID 17236141.
External links
- HOXD11+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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