Biology:TAL2
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T-cell acute lymphocytic leukemia 2, also known as TAL2, is a protein which in humans is encoded by the TAL2 gene.[1][2]
Function
TAL2 is a member of the basic helix-loop-helix family of transcription factors.[3]
Clinical significance
Tumor-specific alterations of the TAL2 gene occurs in some patients with T-cell acute lymphoblastic leukemia (T-ALL).[2][4]
References
- ↑ "Entrez Gene: TAL2 T-cell acute lymphocytic leukemia 2". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6887.
- ↑ 2.0 2.1 "TAL2, a helix-loop-helix gene activated by the (7;9)(q34;q32) translocation in human T-cell leukemia". Proc. Natl. Acad. Sci. U.S.A. 88 (24): 11416–20. December 1991. doi:10.1073/pnas.88.24.11416. PMID 1763056. Bibcode: 1991PNAS...8811416X.
- ↑ Baer R (December 1993). "TAL1, TAL2 and LYL1: a family of basic helix-loop-helix proteins implicated in T cell acute leukaemia". Semin. Cancer Biol. 4 (6): 341–7. PMID 8142619.
- ↑ "Distinct t(7;9)(q34;q32) breakpoints in healthy individuals and individuals with T-ALL". Nat. Genet. 33 (3): 342–4. March 2003. doi:10.1038/ng1092. PMID 12567187.
Further reading
- "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. 2004. doi:10.1101/gr.2596504. PMID 15489334.
- "DNA sequence and analysis of human chromosome 9.". Nature 429 (6990): 369–74. 2004. doi:10.1038/nature02465. PMID 15164053. Bibcode: 2004Natur.429..369H.
- "Distinct t(7;9)(q34;q32) breakpoints in healthy individuals and individuals with T-ALL.". Nat. Genet. 33 (3): 342–4. 2003. doi:10.1038/ng1092. PMID 12567187.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932.
- "Products of the TAL2 oncogene in leukemic T cells: bHLH phosphoproteins with DNA-binding activity.". Oncogene 9 (5): 1437–46. 1994. PMID 8152805.
- "Specific in vivo association between the bHLH and LIM proteins implicated in human T cell leukemia.". EMBO J. 13 (20): 4831–9. 1994. doi:10.1002/j.1460-2075.1994.tb06809.x. PMID 7957052.
- "TAL2, a helix-loop-helix gene activated by the (7;9)(q34;q32) translocation in human T-cell leukemia.". Proc. Natl. Acad. Sci. U.S.A. 88 (24): 11416–20. 1992. doi:10.1073/pnas.88.24.11416. PMID 1763056.
- "T-cell acute lymphoblastic leukemia--the associated gene SCL/tal codes for a 42-Kd nuclear phosphoprotein.". Blood 80 (11): 2858–66. 1992. doi:10.1182/blood.V80.11.2858.bloodjournal80112858. PMID 1450410.
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