Biology:OTX1
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Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Homeobox protein OTX1 is a protein that in humans is encoded by the OTX1 gene.[1][2]
Function
This gene encodes a member of the bicoid sub-family of homeodomain-containing transcription factors. The encoded protein acts as a transcription factor and may play a role in brain and sensory organ development. The Otx gene is active in the region of the first gill arch, which is related to the upper and lower jaw and two of the bones of the ear.[3] A similar protein in mice is required for proper brain and sensory organ development and can cause epilepsy.[2]
References
- ↑ "Chromosome locations of human EMX and OTX genes". Genomics 22 (1): 41–5. July 1994. doi:10.1006/geno.1994.1343. PMID 7959790.
- ↑ 2.0 2.1 "Entrez Gene: OTX1 orthodenticle homeobox 1". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5013.
- ↑ Shubin, Neil "Your Inner Fish" 2009
Further reading
- "A vertebrate gene related to orthodenticle contains a homeodomain of the bicoid class and demarcates anterior neuroectoderm in the gastrulating mouse embryo". The EMBO Journal 12 (7): 2735–47. July 1993. doi:10.1002/j.1460-2075.1993.tb05935.x. PMID 8101484.
- "Epilepsy and brain abnormalities in mice lacking the Otx1 gene". Nature Genetics 14 (2): 218–22. October 1996. doi:10.1038/ng1096-218. PMID 8841200.
- "Developmental rescue of Drosophila cephalic defects by the human Otx genes". Proceedings of the National Academy of Sciences of the United States of America 95 (7): 3737–42. March 1998. doi:10.1073/pnas.95.7.3737. PMID 9520436. Bibcode: 1998PNAS...95.3737N.
- "Cortical neurons require Otx1 for the refinement of exuberant axonal projections to subcortical targets". Neuron 24 (4): 819–31. December 1999. doi:10.1016/S0896-6273(00)81030-2. PMID 10624946.
- "Fine mapping of the chromosome 2p12-16 dyslexia susceptibility locus: quantitative association analysis and positional candidate genes SEMA4F and OTX1". Psychiatric Genetics 12 (1): 35–41. March 2002. doi:10.1097/00041444-200203000-00005. PMID 11901358.
- "Otx2 regulates the extent, identity and fate of neuronal progenitor domains in the ventral midbrain". Development 131 (9): 2037–48. May 2004. doi:10.1242/dev.01107. PMID 15105370.
- "Towards a proteome-scale map of the human protein-protein interaction network". Nature 437 (7062): 1173–8. October 2005. doi:10.1038/nature04209. PMID 16189514. Bibcode: 2005Natur.437.1173R.
External links
- OTX1+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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