Biology:Hepatocyte nuclear factor 4 gamma

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Short description: Protein-coding gene in the species Homo sapiens

A representation of the 3D structure of the protein myoglobin showing turquoise α-helices.
Generic protein structure example

Hepatocyte nuclear factor 4 gamma (HNF4G) also known as NR2A2 (nuclear receptor subfamily 2, group A, member 2) is a nuclear receptor that in humans is encoded by the HNF4G gene.[1][2][3]

Function

HNF4G is a transcription factor that has been shown to play a significant role in intestinal epithelial cell differentiation and function. Research using integrative multi-omics analysis of intestinal organoid differentiation has revealed that HNF4G acts as a master regulator of gene regulation in differentiation towards the enterocyte lineage.[4] The study demonstrated widespread binding to promoters and enhancers that are activated in enterocytes, and that the loss of Hnf4g results in a partial loss of enterocyte differentiation, indicating its importance in maintaining the enterocyte lineage.

See also

References

  1. ↑ "Entrez Gene: HNF4G hepatocyte nuclear factor 4, gamma". https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=3174. 
  2. ↑ "Human hepatocyte nuclear factor 4 isoforms are encoded by distinct and differentially expressed genes". Molecular and Cellular Biology 16 (3): 925–931. March 1996. doi:10.1128/mcb.16.3.925. PMID 8622695. 
  3. ↑ "Hepatocyte nuclear factor 4 is a transcription factor that constitutively binds fatty acids". Structure 10 (9): 1225–1234. September 2002. doi:10.1016/S0969-2126(02)00829-8. PMID 12220494. 
  4. ↑ "Integrative multi-omics analysis of intestinal organoid differentiation". Molecular Systems Biology 14 (6). June 2018. doi:10.15252/msb.20188227. PMID 29945941. 

Further reading

  • "Hepatocyte nuclear factor-4gamma: cDNA sequence, gene organization, and mutation screening in early-onset autosomal-dominant type 2 diabetes". Diabetes 48 (10): 2099–2102. October 1999. doi:10.2337/diabetes.48.10.2099. PMID 10512380. 
  • "Hepatocyte nuclear factor-4 alpha/gamma and hepatocyte nuclear factor-1 alpha as causal factors of interindividual difference in the expression of human dihydrodiol dehydrogenase 4 mRNA in human livers". Pharmacogenetics 13 (1): 49–53. January 2003. doi:10.1097/00008571-200301000-00007. PMID 12544512. 



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