Biology:Iroquois homeobox factor
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Short description: Protein family
Iroquois homeobox factors are a family of homeodomain transcription factors that play a role in many developmental processes.[1][2] The loci were named for the flies carrying mutations in one of these genes, which are devoid of all bristles in the lateral part of the notum, leaving only a median stripe of bristles, similar to the Iroquois tribes which shaved all but a medial stripe of hairs on the head.[3]
Human genes that encode Iroquois homeobox factors include:[2]
- IrxA sub-group: IRX1, IRX2, IRX4
- IrxB sub-group: IRX3, IRX5, IRX6
- Iroquois-like gene: MKX
References
- ↑ "Iroquois genes: genomic organization and function in vertebrate neural development". Curr. Opin. Genet. Dev. 12 (4): 403–8. August 2002. doi:10.1016/S0959-437X(02)00317-9. PMID 12100884.
- ↑ 2.0 2.1 "Evolutionary history of the iroquois/Irx genes in metazoans". BMC Evol. Biol. 9: 74. 2009. doi:10.1186/1471-2148-9-74. PMID 19368711.
- ↑ "iroquois: a prepattern gene that controls the formation of bristles on the thorax ofDrosophila". Mech. Dev. 59 (1): 63–72. September 1996. doi:10.1016/0925-4773(96)00577-1. PMID 8892233.
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