Biology:HEYL
From HandWiki
Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Hairy/enhancer-of-split related with YRPW motif-like protein is a protein that in humans is encoded by the HEYL gene.[1][2][3]
This gene encodes a member of the hairy and enhancer of split-related (HESR) family of basic helix-loop-helix (bHLH)-type transcription factors. The sequence of the encoded protein contains a conserved bHLH and orange domain, but its YRPW motif has diverged from other HESR family members. It is thought to be an effector of Notch signaling and a regulator of cell fate decisions. Alternatively spliced transcript variants have been found, but their biological validity has not been determined.[3]
References
- ↑ "Hey genes: a novel subfamily of hairy- and Enhancer of split related genes specifically expressed during mouse embryogenesis". Mech Dev 85 (1–2): 173–7. Sep 1999. doi:10.1016/S0925-4773(99)00080-5. PMID 10415358.
- ↑ "Characterization of the human and mouse HEY1, HEY2, and HEYL genes: cloning, mapping, and mutation screening of a new bHLH gene family". Genomics 66 (2): 195–203. Aug 2000. doi:10.1006/geno.2000.6200. PMID 10860664.
- ↑ 3.0 3.1 "Entrez Gene: HEYL hairy/enhancer-of-split related with YRPW motif-like". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=26508.
Further reading
- "HES and HERP families: multiple effectors of the Notch signaling pathway.". J. Cell. Physiol. 194 (3): 237–55. 2003. doi:10.1002/jcp.10208. PMID 12548545.
- "Hesr, a mediator of the Notch signaling, functions in heart and vessel development.". Trends Cardiovasc. Med. 15 (5): 190–4. 2006. doi:10.1016/j.tcm.2005.05.005. PMID 16165016.
- "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. 1997. doi:10.1101/gr.6.9.791. PMID 8889548.
- "The basic helix-loop-helix transcription factors dHAND and eHAND exhibit dimerization characteristics that suggest complex regulation of function.". J. Biol. Chem. 275 (43): 33567–73. 2000. doi:10.1074/jbc.M005888200. PMID 10924525.
- "Members of the HRT family of basic helix-loop-helix proteins act as transcriptional repressors downstream of Notch signaling.". Proc. Natl. Acad. Sci. U.S.A. 97 (25): 13655–60. 2001. doi:10.1073/pnas.250485597. PMID 11095750.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "Functional proteomics mapping of a human signaling pathway.". Genome Res. 14 (7): 1324–32. 2004. doi:10.1101/gr.2334104. PMID 15231748.
- "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. 2005. doi:10.1038/nature04209. PMID 16189514. Bibcode: 2005Natur.437.1173R.
External links
- HEYL+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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