Biology:FOXP4
 Generic protein structure example |
Forkhead box protein P4 is a protein that in humans is encoded by the FOXP4 gene.[1]
This gene belongs to subfamily P of the forkhead box (FOX) transcription factor family. Forkhead box transcription factors play important roles in the regulation of tissue- and cell type-specific gene transcription during both development and adulthood. Many members of the forkhead box gene family, including members of subfamily P, have roles in mammalian oncogenesis. This gene may play a role in the development of tumors of the kidney and larynx. Alternative splicing of this gene produces multiple transcript variants, some encoding different isoforms.[1] It also is a major factor in developing Long COVID as such, increasing the chances of developing the little-understood syndrome 1.6 fold, a finding which has major implications for COVID-19 pandemic research.[2][3]
References
- ↑ 1.0 1.1 "Entrez Gene: FOXP4 forkhead box P4". https://www.ncbi.nlm.nih.gov/gene?Db=gene&Cmd=ShowDetailView&TermToSearch=116113.
- ↑ "Gene linked to long COVID found in analysis of thousands of patients". Nature 619 (7970): 445. July 2023. doi:10.1038/d41586-023-02269-2. PMID 37433943. Bibcode: 2023Natur.619..445L.
- ↑ "Genome-wide association study of long COVID". Nature Genetics 57 (6): 1402–1417. June 2025. doi:10.1038/s41588-025-02100-w. PMID 40399555.
Further reading
- "Human FOX gene family (Review)". International Journal of Oncology 25 (5): 1495–1500. 2005. doi:10.3892/ijo.25.5.1495. PMID 15492844.
- "Foxp4: a novel member of the Foxp subfamily of winged-helix genes co-expressed with Foxp1 and Foxp2 in pulmonary and gut tissues". Gene Expression Patterns 2 (3–4): 223–228. 2003. doi:10.1016/S1567-133X(02)00058-3. PMID 12617805. (Retracted, see doi:10.1016/S0925-4773(03)00085-6)
- "FoxP4, a novel forkhead transcription factor". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression 1627 (2–3): 147–152. June 2003. doi:10.1016/S0167-4781(03)00074-5. PMID 12818433.
- "Foxp4: a novel member of the Foxp subfamily of winged-helix genes co-expressed with Foxp1 and Foxp2 in pulmonary and gut tissues". Mechanisms of Development 119 (Suppl 1): S197–202. 2002. doi:10.1016/S0925-4773(03)00116-3. PMID 14516685.
- "Transcriptional and DNA Binding Activity of the Foxp1/2/4 Family Is Modulated by Heterotypic and Homotypic Protein Interactions". Molecular and Cellular Biology 24 (2): 809–822. 2004. doi:10.1128/MCB.24.2.809-822.2004. PMID 14701752.
- "Transcriptional genomics associates FOX transcription factors with human heart failure". Circulation 114 (12): 1269–1276. September 2006. doi:10.1161/CIRCULATIONAHA.106.632430. PMID 16952980.
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