Biology:FOXP4
 Generic protein structure example |
Forkhead box protein P4 is a protein that in humans is encoded by the FOXP4 gene.[1]
This gene belongs to subfamily P of the forkhead box (FOX) transcription factor family. Forkhead box transcription factors play important roles in the regulation of tissue- and cell type-specific gene transcription during both development and adulthood. Many members of the forkhead box gene family, including members of subfamily P, have roles in mammalian oncogenesis. This gene may play a role in the development of tumors of the kidney and larynx. Alternative splicing of this gene produces multiple transcript variants, some encoding different isoforms.[1] It also is a major factor in developing Long COVID as such, increasing the chances of developing the little-understood syndrome 1.6 fold, a finding which has major implications for COVID-19 pandemic research.[2]
References
- ↑ 1.0 1.1 "Entrez Gene: FOXP4 forkhead box P4". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=116113.
- ↑ Ledford, Heidi (July 11, 2023). "Gene linked to long COVID found in analysis of thousands of patients". Nature 619 (7970): 445. doi:10.1038/d41586-023-02269-2. PMID 37433943. https://www.nature.com/articles/d41586-023-02269-2.
Further reading
- "Human FOX gene family (Review)". Int. J. Oncol. 25 (5): 1495–500. 2005. doi:10.3892/ijo.25.5.1495. PMID 15492844.
- Strausberg RL; Feingold EA; Grouse LH; Derge, JG; Klausner, RD; Collins, FS; Wagner, L; Shenmen, CM et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
- "Foxp4: a novel member of the Foxp subfamily of winged-helix genes co-expressed with Foxp1 and Foxp2 in pulmonary and gut tissues". Gene Expr. Patterns 2 (3–4): 223–8. 2003. doi:10.1016/S1567-133X(02)00058-3. PMID 12617805.
- Teufel A; Wong EA; Mukhopadhyay M; Malik, N; Westphal, H (2003). "FoxP4, a novel forkhead transcription factor". Biochim. Biophys. Acta 1627 (2–3): 147–52. doi:10.1016/S0167-4781(03)00074-5. PMID 12818433. https://zenodo.org/record/1259887.
- "Foxp4: a novel member of the Foxp subfamily of winged-helix genes co-expressed with Foxp1 and Foxp2 in pulmonary and gut tissues". Mech. Dev. 119 (Suppl 1): S197–202. 2002. doi:10.1016/S0925-4773(03)00116-3. PMID 14516685.
- "Transcriptional and DNA Binding Activity of the Foxp1/2/4 Family Is Modulated by Heterotypic and Homotypic Protein Interactions". Mol. Cell. Biol. 24 (2): 809–22. 2004. doi:10.1128/MCB.24.2.809-822.2004. PMID 14701752.
- Ota T; Suzuki Y; Nishikawa T; Otsuki, Tetsuji; Sugiyama, Tomoyasu; Irie, Ryotaro; Wakamatsu, Ai; Hayashi, Koji et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Gerhard DS; Wagner L; Feingold EA; Shenmen, CM; Grouse, LH; Schuler, G; Klein, SL; Old, S et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
- Hannenhalli S; Putt ME; Gilmore JM; Wang, J; Parmacek, MS; Epstein, JA; Morrisey, EE; Margulies, KB et al. (2006). "Transcriptional genomics associates FOX transcription factors with human heart failure". Circulation 114 (12): 1269–76. doi:10.1161/CIRCULATIONAHA.106.632430. PMID 16952980.
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