Biology:KLF8
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Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
Krueppel-like factor 8 is a protein that in humans is encoded by the KLF8 gene.[1] KLF8 belongs to the family of KLF protein. KLF8 is activated by KLF1 along with KLF3 while KLF3 represses KLF8.[2]
Interactions
KLF8 has been shown to interact with CTBP2.[3]
References
- ↑ "Entrez Gene: KLF8 Kruppel-like factor 8". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11279.
- ↑ Alister P. W. Funnell. "Generation of Mice Deficient in both KLF3/BKLF and KLF8 Reveals a Genetic Interaction and a Role for These Factors in Embryonic Globin Gene Silencing". https://mcb.asm.org/content/33/15/2976#sec-22.
- ↑ "Human Krüppel-like factor 8: a CACCC-box binding protein that associates with CtBP and represses transcription". Nucleic Acids Research 28 (9): 1955–62. May 2000. doi:10.1093/nar/28.9.1955. PMID 10756197.
Further reading
- "Human Krüppel-like factor 8: a CACCC-box binding protein that associates with CtBP and represses transcription". Nucleic Acids Research 28 (9): 1955–62. May 2000. doi:10.1093/nar/28.9.1955. PMID 10756197.
- "Abnormal expression of the KLF8 (ZNF741) gene in a female patient with an X;autosome translocation t(X;21)(p11.2;q22.3) and non-syndromic mental retardation". Journal of Medical Genetics 39 (2): 113–7. Feb 2002. doi:10.1136/jmg.39.2.113. PMID 11836360.
- "The LIM protein FHL3 binds basic Krüppel-like factor/Krüppel-like factor 3 and its co-repressor C-terminal-binding protein 2". The Journal of Biological Chemistry 278 (15): 12786–95. Apr 2003. doi:10.1074/jbc.M300587200. PMID 12556451.
- "Identification of transcription factor KLF8 as a downstream target of focal adhesion kinase in its regulation of cyclin D1 and cell cycle progression". Molecular Cell 11 (6): 1503–15. Jun 2003. doi:10.1016/S1097-2765(03)00179-5. PMID 12820964.
- "A functional screen for Krüppel-like factors that regulate the human gamma-globin gene through the CACCC promoter element". Blood Cells, Molecules & Diseases 35 (2): 227–35. 2006. doi:10.1016/j.bcmd.2005.04.009. PMID 16023392.
- "KLF8 transcription factor participates in oncogenic transformation". Oncogene 26 (3): 456–61. Jan 2007. doi:10.1038/sj.onc.1209796. PMID 16832343.
- "Systematic RNAi studies on the role of Sp/KLF factors in globin gene expression and erythroid differentiation". Journal of Molecular Biology 366 (4): 1064–73. Mar 2007. doi:10.1016/j.jmb.2006.12.047. PMID 17224162.
- "Krüppel-like factor 8 induces epithelial to mesenchymal transition and epithelial cell invasion". Cancer Research 67 (15): 7184–93. Aug 2007. doi:10.1158/0008-5472.CAN-06-4729. PMID 17671186.
External links
- KLF8 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH)
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