Biology:ELK4

Short description: Protein-coding gene in the species Homo sapiens

Generic protein structure example

ETS domain-containing protein Elk-4 is a protein that in humans is encoded by the ELK4 gene.

Function

This gene is a member of the Ets family of transcription factors and of the ternary complex factor (TCF) subfamily. Proteins of the TCF subfamily form a ternary complex by binding to the serum response factor and the serum response element in the promoter of the c-fos proto-oncogene. The protein encoded by this gene is phosphorylated by the kinases, MAPK1 and MAPK8. Several transcript variants have been described for this gene.

Interactions

ELK4 has been shown to interact with:

• BRCA1, and
• Serum response factor

Further reading

• "The ETS-domain transcription factor family". Int. J. Biochem. Cell Biol. 29 (12): 1371–87. 1998. doi:10.1016/S1357-2725(97)00086-1. PMID 9570133. 
• "Ets transcription factors: nuclear effectors of the Ras-MAP-kinase signaling pathway". Trends Biochem. Sci. 23 (6): 213–6. 1998. doi:10.1016/S0968-0004(98)01211-0. PMID 9644975. 
• "Characterization of SAP-1, a protein recruited by serum response factor to the c-fos serum response element". Cell 68 (3): 597–612. 1992. doi:10.1016/0092-8674(92)90194-H. PMID 1339307. 
• "Comparative analysis of the ternary complex factors Elk-1, SAP-1a and SAP-2 (ERP/NET)". EMBO J. 14 (11): 2589–601. 1995. doi:10.1002/j.1460-2075.1995.tb07257.x. PMID 7540136. 
• "Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence". Nature 377 (6547 Suppl): 3–174. 1995. PMID 7566098. http://www.columbia.edu/itc/biology/pollack/w4065/client_edit/readings/nature377_3.pdf. 
• "Characterization of SAP-1, a protein recruited by serum response factor to the c-fos serum response element". Cell 76 (2): 411. 1994. PMID 8293474. http://download.cell.com/pdf/PII0092867494903476.pdf. Retrieved 2011-06-29. 
• "Activation of the Sap-1a transcription factor by the c-Jun N-terminal kinase (JNK) mitogen-activated protein kinase". J. Biol. Chem. 272 (7): 4219–24. 1997. doi:10.1074/jbc.272.7.4219. PMID 9020136. 
• "Convergence of MAP kinase pathways on the ternary complex factor Sap-1a". EMBO J. 16 (7): 1620–7. 1997. doi:10.1093/emboj/16.7.1620. PMID 9130707. 
• "p38-2, a novel mitogen-activated protein kinase with distinct properties". J. Biol. Chem. 272 (31): 19509–17. 1997. doi:10.1074/jbc.272.31.19509. PMID 9235954. 
• "Structures of SAP-1 bound to DNA targets from the E74 and c-fos promoters: insights into DNA sequence discrimination by Ets proteins". Mol. Cell 2 (2): 201–12. 1998. doi:10.1016/S1097-2765(00)80130-6. PMID 9734357. 
• "Id helix-loop-helix proteins inhibit nucleoprotein complex formation by the TCF ETS-domain transcription factors". EMBO J. 18 (4): 968–76. 1999. doi:10.1093/emboj/18.4.968. PMID 10022839. 
• "Activation of the protein kinase ERK5/BMK1 by receptor tyrosine kinases. Identification and characterization of a signaling pathway to the nucleus". J. Biol. Chem. 274 (37): 26563–71. 1999. doi:10.1074/jbc.274.37.26563. PMID 10473620. 
• "c-Fos oncogene regulator Elk-1 interacts with BRCA1 splice variants BRCA1a/1b and enhances BRCA1a/1b-mediated growth suppression in breast cancer cells". Oncogene 20 (11): 1357–67. 2001. doi:10.1038/sj.onc.1204256. PMID 11313879. 
• "The B-box dominates SAP-1-SRF interactions in the structure of the ternary complex". EMBO J. 20 (12): 3018–28. 2001. doi:10.1093/emboj/20.12.3018. PMID 11406578. 
• "Crystal structure of a ternary SAP-1/SRF/c-fos SRE DNA complex". J. Mol. Biol. 314 (3): 495–506. 2002. doi:10.1006/jmbi.2001.5138. PMID 11846562. 

External links

• ELK4+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
• FactorBook ELK4

This article incorporates text from the United States National Library of Medicine, which is in the public domain.