Biology:POU2F1
From HandWiki
Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
POU domain, class 2, transcription factor 1 is a protein that in humans is encoded by the POU2F1 gene.[1][2]
Interactions
POU2F1 has been shown to interact with:
- EPRS,[3]
- Glucocorticoid receptor,[4][5][6]
- Glyceraldehyde 3-phosphate dehydrogenase,[7]
- Host cell factor C1,[8][9]
- Ku80,[10][11]
- MNAT1[12]
- NPAT,[7]
- Nuclear receptor co-repressor 2,[13]
- POU2AF1,[14][15][16]
- RELA,[17]
- Retinoid X receptor alpha,[4][18]
- SNAPC4,[14][19]
- Sp1 transcription factor,[20][21] and
- TATA binding protein.[22]
See also
References
- ↑ "Differential phosphorylation of the transcription factor Oct1 during the cell cycle". Science 253 (5023): 1022–6. October 1991. doi:10.1126/science.1887216. PMID 1887216.
- ↑ "Entrez Gene: POU2F1 POU domain, class 2, transcription factor 1". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5451.
- ↑ "Interaction of Oct-1 and automodification domain of poly(ADP-ribose) synthetase". FEBS Lett. 424 (1–2): 27–32. March 1998. doi:10.1016/s0014-5793(98)00131-8. PMID 9537509.
- ↑ 4.0 4.1 "Selective binding of steroid hormone receptors to octamer transcription factors determines transcriptional synergism at the mouse mammary tumor virus promoter". J. Biol. Chem. 274 (38): 26713–9. September 1999. doi:10.1074/jbc.274.38.26713. PMID 10480874.
- ↑ "Developmental effects of ectopic expression of the glucocorticoid receptor DNA binding domain are alleviated by an amino acid substitution that interferes with homeodomain binding". Mol. Cell. Biol. 19 (10): 7106–22. October 1999. doi:10.1128/mcb.19.10.7106. PMID 10490647.
- ↑ "Recruitment of octamer transcription factors to DNA by glucocorticoid receptor". Mol. Cell. Biol. 18 (6): 3416–30. June 1998. doi:10.1128/mcb.18.6.3416. PMID 9584182.
- ↑ 7.0 7.1 "Gene switching by metabolic enzymes--how did you get on the invitation list?". Cell 114 (2): 150–2. July 2003. doi:10.1016/s0092-8674(03)00563-4. PMID 12887915.
- ↑ "HCF-dependent nuclear import of VP16". EMBO J. 18 (2): 480–9. January 1999. doi:10.1093/emboj/18.2.480. PMID 9889203.
- ↑ "Purification of the cellular C1 factor required for the stable recognition of the Oct-1 homeodomain by the herpes simplex virus alpha-trans-induction factor (VP16)". J. Biol. Chem. 268 (9): 6525–34. March 1993. doi:10.1016/S0021-9258(18)53282-8. PMID 8454622.
- ↑ "The binding of Ku antigen to homeodomain proteins promotes their phosphorylation by DNA-dependent protein kinase". J. Biol. Chem. 276 (20): 16848–56. May 2001. doi:10.1074/jbc.M100768200. PMID 11279128.
- ↑ "Ku antigen, an origin-specific binding protein that associates with replication proteins, is required for mammalian DNA replication". Biochim. Biophys. Acta 1578 (1–3): 59–72. October 2002. doi:10.1016/s0167-4781(02)00497-9. PMID 12393188.
- ↑ "The cyclin-dependent kinase-activating kinase (CAK) assembly factor, MAT1, targets and enhances CAK activity on the POU domains of octamer transcription factors". J. Biol. Chem. 272 (47): 29852–8. November 1997. doi:10.1074/jbc.272.47.29852. PMID 9368058.
- ↑ "Silencing mediator for retinoid and thyroid hormone receptors interacts with octamer transcription factor-1 and acts as a transcriptional repressor". J. Biol. Chem. 276 (13): 9720–5. March 2001. doi:10.1074/jbc.M008531200. PMID 11134019.
- ↑ 14.0 14.1 "The large subunit of basal transcription factor SNAPc is a Myb domain protein that interacts with Oct-1". Mol. Cell. Biol. 18 (1): 368–77. January 1998. doi:10.1128/mcb.18.1.368. PMID 9418884.
- ↑ "Crystal structure of an OCA-B peptide bound to an Oct-1 POU domain/octamer DNA complex: specific recognition of a protein-DNA interface". Genes Dev. 13 (20): 2650–7. October 1999. doi:10.1101/gad.13.20.2650. PMID 10541551.
- ↑ "Expression of the Oct-1 transcription factor and characterization of its interactions with the Bob1 coactivator". Biochemistry 40 (22): 6580–8. June 2001. doi:10.1021/bi010095x. PMID 11380252.
- ↑ "Inflammatory bowel disease is associated with a TNF polymorphism that affects an interaction between the OCT1 and NF(-kappa)B transcription factors". Hum. Mol. Genet. 11 (11): 1281–9. May 2002. doi:10.1093/hmg/11.11.1281. PMID 12019209.
- ↑ "Functional interaction between Oct-1 and retinoid X receptor". J. Biol. Chem. 274 (27): 19103–8. July 1999. doi:10.1074/jbc.274.27.19103. PMID 10383413.
- ↑ "Crystallization of the Oct-1/SNAP190 peptide/DNA complex". Acta Crystallogr. D 58 (Pt 3): 511–2. March 2002. doi:10.1107/s0907444901021461. PMID 11856838.
- ↑ "The transcription factors Sp1 and Oct-1 interact physically to regulate human U2 snRNA gene expression". Nucleic Acids Res. 24 (11): 1981–6. June 1996. doi:10.1093/nar/24.11.1981. PMID 8668525.
- ↑ "A set of proteins interacting with transcription factor Sp1 identified in a two-hybrid screening". Mol. Cell. Biochem. 210 (1–2): 131–42. July 2000. doi:10.1023/A:1007177623283. PMID 10976766.
- ↑ "The POU domains of the Oct1 and Oct2 transcription factors mediate specific interaction with TBP". Nucleic Acids Res. 22 (9): 1655–62. May 1994. doi:10.1093/nar/22.9.1655. PMID 8202368.
Further reading
- "The gene for the ubiquitous octamer-binding protein Oct–1 is on human chromosome 1, region cen-q32, and near Ly-22 and Ltw-4 on mouse chromosome 1". Genomics 6 (4): 666–72. 1990. doi:10.1016/0888-7543(90)90502-L. PMID 2341156.
- "The ubiquitous octamer-binding protein Oct–1 contains a POU domain with a homeo box subdomain". Genes Dev. 2 (12A): 1582–99. 1989. doi:10.1101/gad.2.12a.1582. PMID 2905684.
- "Interaction of Oct–1 with TFIIB. Implications for a novel response elicited through the proximal octamer site of the lipoprotein lipase promoter". J. Biol. Chem. 270 (33): 19613–23. 1995. doi:10.1074/jbc.270.33.19613. PMID 7642649.
- "Solution structure of the Oct–1 POU homeodomain determined by NMR and restrained molecular dynamics". J. Biomol. NMR 6 (1): 23–32. 1995. doi:10.1007/BF00417488. PMID 7663141.
- "In vitro and in vivo binding of human immunodeficiency virus type 1 Tat protein and Sp1 transcription factor". J. Virol. 67 (10): 6224–33. 1993. doi:10.1128/JVI.67.10.6224-6233.1993. PMID 7690421.
- "High mobility group protein 2 functionally interacts with the POU domains of octamer transcription factors". EMBO J. 14 (6): 1198–208. 1995. doi:10.1002/j.1460-2075.1995.tb07103.x. PMID 7720710.
- "The human OTF1 locus which overlaps the CD3Z gene is located at 1q22→q23". Cytogenet. Cell Genet. 68 (3–4): 231–2. 1995. doi:10.1159/000133919. PMID 7842742.
- "Crystal structure of the Oct–1 POU domain bound to an octamer site: DNA recognition with tethered DNA-binding modules". Cell 77 (1): 21–32. 1994. doi:10.1016/0092-8674(94)90231-3. PMID 8156594.
- "The POU domains of the Oct1 and Oct2 transcription factors mediate specific interaction with TBP". Nucleic Acids Res. 22 (9): 1655–62. 1994. doi:10.1093/nar/22.9.1655. PMID 8202368.
- "Purification of the cellular C1 factor required for the stable recognition of the Oct–1 homeodomain by the herpes simplex virus alpha-trans-induction factor (VP16)". J. Biol. Chem. 268 (9): 6525–34. 1993. doi:10.1016/S0021-9258(18)53282-8. PMID 8454622.
- "The solution structure of the Oct–1 POU-specific domain reveals a striking similarity to the bacteriophage lambda repressor DNA-binding domain". Cell 73 (1): 193–205. 1993. doi:10.1016/0092-8674(93)90171-L. PMID 8462099.
- "Solution structure of the POU-specific DNA-binding domain of Oct–1". Nature 362 (6423): 852–5. 1993. doi:10.1038/362852a0. PMID 8479524. Bibcode: 1993Natur.362..852D.
- "The transcription factors Sp1 and Oct–1 interact physically to regulate human U2 snRNA gene expression". Nucleic Acids Res. 24 (11): 1981–6. 1996. doi:10.1093/nar/24.11.1981. PMID 8668525.
- "The cyclin-dependent kinase-activating kinase (CAK) assembly factor, MAT1, targets and enhances CAK activity on the POU domains of octamer transcription factors". J. Biol. Chem. 272 (47): 29852–8. 1997. doi:10.1074/jbc.272.47.29852. PMID 9368058.
- "The Large Subunit of Basal Transcription Factor SNAPc Is a Myb Domain Protein That Interacts with Oct–1". Mol. Cell. Biol. 18 (1): 368–77. 1998. doi:10.1128/mcb.18.1.368. PMID 9418884.
- "Interaction of Oct–1 and automodification domain of poly(ADP-ribose) synthetase". FEBS Lett. 424 (1–2): 27–32. 1998. doi:10.1016/S0014-5793(98)00131-8. PMID 9537509.
- "Recruitment of Octamer Transcription Factors to DNA by Glucocorticoid Receptor". Mol. Cell. Biol. 18 (6): 3416–30. 1998. doi:10.1128/MCB.18.6.3416. PMID 9584182.
- "HCF-dependent nuclear import of VP16". EMBO J. 18 (2): 480–9. 1999. doi:10.1093/emboj/18.2.480. PMID 9889203.
External links
- POU2F1+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
PDB gallery | |
|---|---|
|
 |  |
