Biology:ZNF238
 Generic protein structure example |
Zinc finger protein 238 (also known as RP58 or ZBTB18) is a zinc finger containing transcription factor that in humans is encoded by the ZNF238 gene.[1][2]
Function
ZNF238 is a gene that plays a major role in the "promotion of ordered and correctly timed neurogenesis leading to proper layer formation and cortical growth."[3] The loss of ZNF238 has been observed to cause microcephaly, agenesis of the corpus callosum, malformation of layers in the cerebral cortex, and cerebellar hypoplasia.[3] Additionally, its absence can cause a decrease in Ngn2 and Neurod1 (in progenitor cells, and an increase thereof in mutant neurons), with the result of less progenitor cells and an increase in neuronal differentiation and glial cell growth.[3] ZNF238 also regulates repressed genes that, if left unchecked, can lead to glioma progression. Furthermore, an absence of ZNF238 results in upregulation of the epithelial-mesenchymal transition process.
In tumors such as medulloblastomas, the loss of ZNF238 can disorganize the tumor's cellular divisional processes, resulting in a cellularly diverse neoplasm. This new diversity has been observed to increase the invasiveness of the tumor, yielding proliferation into more areas of the brain than before the loss of ZNF238.
C2H2-type zinc finger proteins, such as ZNF238, act on the molecular level as transcriptional activators or repressors and are involved in chromatin assembly.[4]
Interactions
ZNF238 has been shown to interact with DNMT3A.[5]
References
- ↑ "C2H2-171: a novel human cDNA representing a developmentally regulated POZ domain/zinc finger protein preferentially expressed in brain". International Journal of Developmental Neuroscience 15 (7): 891–9. November 1997. doi:10.1016/S0736-5748(97)00034-8. PMID 9568537. https://zenodo.org/record/1260081.
- ↑ "Isolation and characterization of a cDNA encoding a Translin-like protein, TRAX". FEBS Letters 401 (2–3): 109–12. January 1997. doi:10.1016/S0014-5793(96)01444-5. PMID 9013868.
- ↑ 3.0 3.1 3.2 "RP58/ZNF238 directly modulates proneurogenic gene levels and is required for neuronal differentiation and brain expansion". Cell Death and Differentiation 19 (4): 692–702. April 2012. doi:10.1038/cdd.2011.144. PMID 22095278.
- ↑ "Entrez Gene: ZNF238 zinc finger protein 238". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10472.
- ↑ "Dnmt3a binds deacetylases and is recruited by a sequence-specific repressor to silence transcription". The EMBO Journal 20 (10): 2536–44. May 2001. doi:10.1093/emboj/20.10.2536. PMID 11350943.
Further reading
- "Initial assessment of human gene diversity and expression patterns based upon 83 million nucleotides of cDNA sequence". Nature 377 (6547 Suppl): 3–174. September 1995. PMID 7566098.
- "Rapid isolation and characterization of 118 novel C2H2-type zinc finger cDNAs expressed in human brain". Human Molecular Genetics 4 (4): 685–91. April 1995. doi:10.1093/hmg/4.4.685. PMID 7633419.
- "RP58 associates with condensed chromatin and mediates a sequence-specific transcriptional repression". The Journal of Biological Chemistry 273 (41): 26698–704. October 1998. doi:10.1074/jbc.273.41.26698. PMID 9756912.
- "Crystal structure of the BTB domain from PLZF". Proceedings of the National Academy of Sciences of the United States of America 95 (21): 12123–8. October 1998. doi:10.1073/pnas.95.21.12123. PMID 9770450. Bibcode: 1998PNAS...9512123F.
- "Structural analysis of the gene encoding RP58, a sequence-specific transrepressor associated with heterochromatin". Gene 242 (1–2): 59–64. January 2000. doi:10.1016/S0378-1119(99)00477-1. PMID 10721697.
- "Dnmt3a binds deacetylases and is recruited by a sequence-specific repressor to silence transcription". The EMBO Journal 20 (10): 2536–44. May 2001. doi:10.1093/emboj/20.10.2536. PMID 11350943.
External links
- ZNF238+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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