Biology:ING2

Short description: Protein-coding gene in the species Homo sapiens

Generic protein structure example

Inhibitor of growth protein 2 is a protein that in humans is encoded by the ING2 gene.

Function

This gene is a member of the inhibitor of growth (ING) family. Members of the ING family associate with and modulate the activity of histone acetyltransferase (HAT) and histone deacetylase (HDAC) complexes and function in DNA repair and apoptosis.

Further reading

• "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research 6 (9): 791–806. Sep 1996. doi:10.1101/gr.6.9.791. PMID 8889548. 
• "DNA damage-inducible gene p33ING2 negatively regulates cell proliferation through acetylation of p53". Proceedings of the National Academy of Sciences of the United States of America 98 (17): 9671–6. Aug 2001. doi:10.1073/pnas.161151798. PMID 11481424. Bibcode: 2001PNAS...98.9671N. 
• "Role of the Sin3-histone deacetylase complex in growth regulation by the candidate tumor suppressor p33(ING1)". Molecular and Cellular Biology 22 (3): 835–48. Feb 2002. doi:10.1128/MCB.22.3.835-848.2002. PMID 11784859. 
• "The PHD finger of the chromatin-associated protein ING2 functions as a nuclear phosphoinositide receptor". Cell 114 (1): 99–111. Jul 2003. doi:10.1016/S0092-8674(03)00480-X. PMID 12859901. 
• "Loss of heterozygosity on chromosome 4q32-35 in sporadic basal cell carcinomas: evidence for the involvement of p33ING2/ING1L and SAP30 genes". Journal of Cutaneous Pathology 31 (4): 318–22. Apr 2004. doi:10.1111/j.0303-6987.2004.0187.x. PMID 15005689. 
• "Human p32, interacts with B subunit of the CCAAT-binding factor, CBF/NF-Y, and inhibits CBF-mediated transcription activation in vitro". Nucleic Acids Research 32 (12): 3632–41. 2004. doi:10.1093/nar/gkh692. PMID 15243141. 
• "Phylogenetic analysis of the ING family of PHD finger proteins". Molecular Biology and Evolution 22 (1): 104–16. Jan 2005. doi:10.1093/molbev/msh256. PMID 15356280. 
• "The novel tumor suppressor p33ING2 enhances UVB-induced apoptosis in human melanoma cells". Experimental Cell Research 304 (2): 531–43. Apr 2005. doi:10.1016/j.yexcr.2004.11.023. PMID 15748897. 
• "High-throughput mapping of a dynamic signaling network in mammalian cells". Science 307 (5715): 1621–5. Mar 2005. doi:10.1126/science.1105776. PMID 15761153. Bibcode: 2005Sci...307.1621B. 
• "ING2 regulates the onset of replicative senescence by induction of p300-dependent p53 acetylation". Molecular and Cellular Biology 25 (15): 6639–48. Aug 2005. doi:10.1128/MCB.25.15.6639-6648.2005. PMID 16024799. 
• "Alterations in novel candidate tumor suppressor genes, ING1 and ING2 in human lung cancer". Oncology Reports 15 (3): 545–9. Mar 2006. doi:10.3892/or.15.3.545. PMID 16465410. 
• "The novel tumor suppressor p33ING2 enhances nucleotide excision repair via inducement of histone H4 acetylation and chromatin relaxation". Cancer Research 66 (4): 1906–11. Feb 2006. doi:10.1158/0008-5472.CAN-05-3444. PMID 16488987. 
• "Nuclear ING2 expression is reduced in human cutaneous melanomas". British Journal of Cancer 95 (1): 80–6. Jul 2006. doi:10.1038/sj.bjc.6603205. PMID 16755297. 
• "Leucine zipper-like domain is required for tumor suppressor ING2-mediated nucleotide excision repair and apoptosis". FEBS Letters 580 (16): 3787–93. Jul 2006. doi:10.1016/j.febslet.2006.05.065. PMID 16782091. 
• "Stabilized phosphatidylinositol-5-phosphate analogues as ligands for the nuclear protein ING2: chemistry, biology, and molecular modeling". Journal of the American Chemical Society 129 (20): 6498–506. May 2007. doi:10.1021/ja070195b. PMID 17469822. 

External links

• ING2+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.