Biology:REL
From HandWiki
Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
The proto-oncogene c-Rel is a protein that in humans is encoded by the REL gene.[1] The c-Rel protein is a member of the NF-κB family of transcription factors and contains a Rel homology domain (RHD) at its N-terminus and two C-terminal transactivation domains. c-Rel is a myeloid checkpoint protein that can be targeted for treating cancer.[2] c-Rel has an important role in B-cell survival and proliferation. The REL gene is amplified or mutated in several human B-cell lymphomas, including diffuse large B-cell lymphoma and Hodgkin's lymphoma.[3]
References
- ↑ "I-Rel: a novel rel-related protein that inhibits NF-kappa B transcriptional activity". Genes Dev 6 (5): 745–60. Jun 1992. doi:10.1101/gad.6.5.745. PMID 1577270.
- ↑ "c-Rel is a myeloid checkpoint for cancer immunotherapy". Nature Cancer 1 (5): 507–517. May 2020. doi:10.1038/s43018-020-0061-3. PMID 33458695.
- ↑ "The c-Rel transcription factor and B-cell proliferation: a deal with the devil". Oncogene 23 (13): 2275–86. March 2004. doi:10.1038/sj.onc.1207410. PMID 14755244.
Further reading
- "Aberrant rel/nfkb genes and activity in human cancer.". Oncogene 18 (49): 6938–47. 2000. doi:10.1038/sj.onc.1203221. PMID 10602468.
- "Selection of optimal kappa B/Rel DNA-binding motifs: interaction of both subunits of NF-kappa B with DNA is required for transcriptional activation.". Mol. Cell. Biol. 12 (10): 4412–21. 1992. doi:10.1128/mcb.12.10.4412. PMID 1406630.
- "Identification of complex formation between two intracellular tyrosine kinase substrates: human c-Rel and the p105 precursor of p50 NF-kappa B.". Oncogene 7 (11): 2095–104. 1992. PMID 1437141.
- "v-rel- and c-rel-protein complexes bind to the NF-kappa B site in vitro.". Oncogene 7 (3): 567–72. 1992. PMID 1549370.
- "The RxxRxRxxC motif conserved in all Rel/kappa B proteins is essential for the DNA-binding activity and redox regulation of the v-Rel oncoprotein.". Mol. Cell. Biol. 12 (7): 3094–106. 1992. doi:10.1128/mcb.12.7.3094. PMID 1620118.
- "Alterations at the rel locus in human lymphoma.". Oncogene 6 (7): 1235–41. 1991. PMID 1650444.
- "Regulation of human immunodeficiency virus enhancer function by PRDII-BF1 and c-rel gene products.". J. Virol. 66 (1): 244–50. 1992. doi:10.1128/JVI.66.1.244-250.1992. PMID 1727488.
- "A novel complex between the p65 subunit of NF-kappa B and c-Rel binds to a DNA element involved in the phorbol ester induction of the human urokinase gene.". EMBO J. 11 (1): 205–13. 1992. doi:10.1002/j.1460-2075.1992.tb05043.x. PMID 1740106.
- "Rel-associated pp40: an inhibitor of the rel family of transcription factors.". Science 253 (5025): 1268–71. 1991. doi:10.1126/science.1891714. PMID 1891714. Bibcode: 1991Sci...253.1268D.
- "The v-rel oncogene product is complexed with cellular proteins including its proto-oncogene product and heat shock protein 70.". Virology 175 (1): 149–60. 1990. doi:10.1016/0042-6822(90)90195-W. PMID 2155506.
- "A human rel proto-oncogene cDNA containing an Alu fragment as a potential coding exon.". Oncogene 4 (7): 935–42. 1989. PMID 2666912.
- "Genetic characterization of human c-rel sequences.". Mol. Cell. Biol. 5 (10): 2826–31. 1986. doi:10.1128/mcb.5.10.2826. PMID 3016517.
- "Comparative genetic mapping of cellular rel sequences in man, mouse, and the domestic cat.". Am. J. Hum. Genet. 39 (2): 194–202. 1986. PMID 3529946.
- "Regulation of cell-type-specific interleukin-2 receptor alpha-chain gene expression: potential role of physical interactions between Elf-1, HMG-I(Y), and NF-kappa B family proteins.". Mol. Cell. Biol. 15 (3): 1786–96. 1995. doi:10.1128/mcb.15.3.1786. PMID 7862168.
- "The v-Rel oncoprotein complexes with new Rel- and RelA-related proteins in transformed cells.". Virology 207 (2): 362–8. 1995. doi:10.1006/viro.1995.1095. PMID 7886940.
- Mackman N (1994). "Protease inhibitors block lipopolysaccharide induction of tissue factor gene expression in human monocytic cells by preventing activation of c-Rel/p65 heterodimers.". J. Biol. Chem. 269 (42): 26363–7. doi:10.1016/S0021-9258(18)47202-X. PMID 7929355.
- "Interaction of the v-Rel oncoprotein with cellular transcription factor Sp1.". J. Virol. 68 (11): 7131–8. 1994. doi:10.1128/JVI.68.11.7131-7138.1994. PMID 7933095.
- "Purification, reconstitution, and I kappa B association of the c-Rel-p65 (RelA) complex, a strong activator of transcription.". Mol. Cell. Biol. 14 (4): 2593–603. 1994. doi:10.1128/mcb.14.4.2593. PMID 8139561.
- "Activation of multiple NF-kappa B/Rel DNA-binding complexes by tumor necrosis factor.". Oncogene 9 (5): 1487–92. 1994. PMID 8152812.
External links
- Genes,+rel at the US National Library of Medicine Medical Subject Headings (MeSH)
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