Biology:HIF3A
 Generic protein structure example |
Hypoxia-inducible factor 3 alpha is a protein that in humans is encoded by the HIF3A gene.[1][2][3]
Function
The protein encoded by this gene is the alpha-3 subunit of one of several alpha/beta-subunit heterodimeric transcription factors that regulate many adaptive responses to low oxygen tension (hypoxia). The alpha-3 subunit lacks the transactivation domain found in factors containing either the alpha-1 or alpha-2 subunits. It is thought that factors containing the alpha-3 subunit are negative regulators of hypoxia-inducible gene expression. At least three transcript variants encoding three different isoforms have been found for this gene.[3]
In rats, it plays a negative role in the adaptation to hypoxia, because the inhibition of HIF-3α expression leads to an increase in physical endurance.[4]
Clinical significance
DNA methylation in the introns of HIF3A is associated with BMI an adiposity.[5]
See also
- Hypoxia inducible factors
References
- ↑ "Expression and characterization of hypoxia-inducible factor (HIF)-3alpha in human kidney: suppression of HIF-mediated gene expression by HIF-3alpha". Biochem Biophys Res Commun 287 (4): 808–13. Sep 2001. doi:10.1006/bbrc.2001.5659. PMID 11573933.
- ↑ "Inhibitory PAS domain protein is a negative regulator of hypoxia-inducible gene expression". Nature 414 (6863): 550–4. Dec 2001. doi:10.1038/35107085. PMID 11734856. Bibcode: 2001Natur.414..550M.
- ↑ 3.0 3.1 "Entrez Gene: HIF3A hypoxia inducible factor 3, alpha subunit". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=64344.
- ↑ "HIF-3α mRNA expression changes in different tissues and their role in adaptation to intermittent hypoxia and physical exercise". Pathophysiology 19 (3): 205–14. 2012. doi:10.1016/j.pathophys.2012.06.002. PMID 22884965.
- ↑ "DNA methylation and body-mass index: a genome-wide analysis.". Lancet 383 (9933): 1990–1998. 2014. doi:10.1016/S0140-6736(13)62674-4. PMID 24630777.
Further reading
- "Molecular characterization and chromosomal localization of a third alpha-class hypoxia inducible factor subunit, HIF3alpha.". Gene Expr. 7 (3): 205–13. 1998. PMID 9840812.
- "Inhibitory PAS domain protein (IPAS) is a hypoxia-inducible splicing variant of the hypoxia-inducible factor-3alpha locus.". J. Biol. Chem. 277 (36): 32405–8. 2002. doi:10.1074/jbc.C200328200. PMID 12119283.
- "Multiple splice variants of the human HIF-3 alpha locus are targets of the von Hippel-Lindau E3 ubiquitin ligase complex.". J. Biol. Chem. 278 (13): 11032–40. 2003. doi:10.1074/jbc.M208681200. PMID 12538644.
- "Human HIF-3alpha4 is a dominant-negative regulator of HIF-1 and is down-regulated in renal cell carcinoma.". FASEB J. 19 (11): 1396–406. 2006. doi:10.1096/fj.05-3788com. PMID 16126907.
- "Binding and regulation of hypoxia-inducible factor-1 by the inhibitory PAS proteins.". Biochem. Biophys. Res. Commun. 337 (1): 209–15. 2005. doi:10.1016/j.bbrc.2005.09.038. PMID 16182248.
- "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. 2006. doi:10.1101/gr.4039406. PMID 16344560.
- "Hypoxia upregulates hypoxia inducible factor (HIF)-3alpha expression in lung epithelial cells: characterization and comparison with HIF-1alpha.". Cell Res. 16 (6): 548–58. 2006. doi:10.1038/sj.cr.7310072. PMID 16775626.
- "Comparative mapping reveals multiple rearrangements between pig chromosome 6 and human 19q13.". Anim. Genet. 37 (6): 595–6. 2007. doi:10.1111/j.1365-2052.2006.01516.x. PMID 17121608.
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