Biology:ID1
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Short description: Protein-coding gene in the species Homo sapiens
 Generic protein structure example |
DNA-binding protein inhibitor ID-1 is a protein that in humans is encoded by the ID1 gene.[1][2]
Function
The protein encoded by this gene is a helix-loop-helix (HLH) protein that can form heterodimers with members of the basic HLH family of transcription factors.[1] The encoded protein has no DNA binding activity and therefore can inhibit the DNA binding and transcriptional activation ability of basic HLH proteins with which it interacts.[1] This protein may play a role in cell growth, senescence, and differentiation.[3][4][5] Two transcript variants encoding different isoforms have been found for this gene.[6]
Interactions
ID1 has been shown to interact weakly with MyoD[1][7][8][9][10][11][12] but very tightly with ubiquitously expressed E proteins.[13] E proteins heterodimerize with tissue restricted bHLH proteins such as Myod, NeuroD, etc. to form active transcription complexes so by sequestering E proteins, Id proteins can inhibit tissue restricted gene expression in multiple cell lineages using the same biochemical mechanism. Other interacting partners include CASK.[14]
Clinical significance
ID1 can be used to mark endothelial progenitor cells which are critical to tumor growth and angiogenesis.[15][16] Targeting ID1 results in decreased tumor growth.[17][18] ID1 has been shown to be targeted by cannabidiol in certain gliomas and breast cancers.[19][20]
See also
References
- ↑ 1.0 1.1 1.2 1.3 "The protein Id: a negative regulator of helix-loop-helix DNA binding proteins". Cell 61 (1): 49–59. April 1990. doi:10.1016/0092-8674(90)90214-Y. PMID 2156629.
- ↑ "Id-related genes encoding helix-loop-helix proteins are required for G1 progression and are repressed in senescent human fibroblasts". The Journal of Biological Chemistry 269 (3): 2139–45. January 1994. doi:10.1016/S0021-9258(17)42146-6. PMID 8294468.
- ↑ "Id proteins in development, cell cycle and cancer". Trends in Cell Biology 13 (8): 410–8. August 2003. doi:10.1016/S0962-8924(03)00147-8. PMID 12888293.
- ↑ "Id family of helix-loop-helix proteins in cancer". Nature Reviews. Cancer 5 (8): 603–14. August 2005. doi:10.1038/nrc1673. PMID 16034366.
- ↑ "Id genes are essential for early heart formation". Genes & Development 31 (13): 1325–1338. July 2017. doi:10.1101/gad.300400.117. PMID 28794185.
- ↑ "Entrez Gene: ID1 inhibitor of DNA binding 1, dominant negative helix-loop-helix protein". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3397.
- ↑ "The candidate tumour suppressor protein ING4 regulates brain tumour growth and angiogenesis". Nature 428 (6980): 328–32. March 2004. doi:10.1038/nature02329. PMID 15029197. Bibcode: 2004Natur.428..328G.
- ↑ "Differential interactions of Id proteins with basic-helix-loop-helix transcription factors". The Journal of Biological Chemistry 272 (32): 19785–93. August 1997. doi:10.1074/jbc.272.32.19785. PMID 9242638.
- ↑ "Detection and modulation in vivo of helix-loop-helix protein-protein interactions". The Journal of Biological Chemistry 268 (1): 5–8. January 1993. doi:10.1016/S0021-9258(18)54105-3. PMID 8380166.
- ↑ "Mmip1: a novel leucine zipper protein that reverses the suppressive effects of Mad family members on c-myc". Oncogene 16 (9): 1149–59. March 1998. doi:10.1038/sj.onc.1201634. PMID 9528857.
- ↑ "The LIM-only protein DRAL/FHL2 interacts with and is a corepressor for the promyelocytic leukemia zinc finger protein". The Journal of Biological Chemistry 277 (40): 37045–53. October 2002. doi:10.1074/jbc.M203336200. PMID 12145280.
- ↑ "Id-1 induces proteasome-dependent degradation of the HBX protein". Journal of Molecular Biology 382 (1): 34–43. September 2008. doi:10.1016/j.jmb.2007.06.020. PMID 18674781.
- ↑ "Overexpression of Id protein inhibits the muscle differentiation program: in vivo association of Id with E2A proteins". Genes & Development 6 (8): 1466–79. August 1992. doi:10.1101/gad.6.8.1466. PMID 1644289.
- ↑ "CASK inhibits ECV304 cell growth and interacts with Id1". Biochemical and Biophysical Research Communications 328 (2): 517–21. March 2005. doi:10.1016/j.bbrc.2005.01.014. PMID 15694377.
- ↑ "Id1 and Id3 are required for neurogenesis, angiogenesis and vascularization of tumour xenografts". Nature 401 (6754): 670–7. October 1999. doi:10.1038/44334. PMID 10537105. Bibcode: 1999Natur.401..670L.
- ↑ "Impaired recruitment of bone-marrow-derived endothelial and hematopoietic precursor cells blocks tumor angiogenesis and growth". Nature Medicine 7 (11): 1194–201. November 2001. doi:10.1038/nm1101-1194. PMID 11689883.
- ↑ "Peptide-conjugated antisense oligonucleotides for targeted inhibition of a transcriptional regulator in vivo". Nature Biotechnology 26 (1): 91–100. January 2008. doi:10.1038/nbt1366. PMID 18176556.
- ↑ "Using the transcription factor inhibitor of DNA binding 1 to selectively target endothelial progenitor cells offers novel strategies to inhibit tumor angiogenesis and growth". Cancer Research 70 (18): 7273–82. September 2010. doi:10.1158/0008-5472.CAN-10-1142. PMID 20807818.
- ↑ "Therapeutic reversal of prenatal pontine ID1 signaling in DIPG". Neuro Oncol 23 (supplement 1): i48. June 2021. doi:10.1093/neuonc/noab090.193.
- ↑ "Cannabidiol as a novel inhibitor of Id-1 gene expression in aggressive breast cancer cells". Molecular Cancer Therapeutics 6 (11): 2921–7. November 2007. doi:10.1158/1535-7163.MCT-07-0371. PMID 18025276.
Further reading
- "Id gene expression during development and molecular cloning of the human Id-1 gene". Brain Research. Molecular Brain Research 30 (2): 312–26. June 1995. doi:10.1016/0169-328X(95)00017-M. PMID 7637581.
- "Nucleotide sequence of the cDNA encoding human helix-loop-helix Id-1 protein: identification of functionally conserved residues common to Id proteins". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression 1219 (1): 160–2. September 1994. doi:10.1016/0167-4781(94)90261-5. PMID 8086456.
- "Chromosomal assignment of human ID1 and ID2 genes". Genomics 30 (2): 385–7. November 1995. doi:10.1006/geno.1995.0037. PMID 8586447.
- "Genomic organization, sequence, and chromosomal localization of the human helix-loop-helix Id1 gene". Biochemical and Biophysical Research Communications 231 (3): 628–34. February 1997. doi:10.1006/bbrc.1997.6152. PMID 9070860. https://zenodo.org/record/1229476.
- "Novel regulation of the helix-loop-helix protein Id1 by S5a, a subunit of the 26 S proteasome". The Journal of Biological Chemistry 272 (31): 19140–51. August 1997. doi:10.1074/jbc.272.31.19140. PMID 9235903.
- "Differential interactions of Id proteins with basic-helix-loop-helix transcription factors". The Journal of Biological Chemistry 272 (32): 19785–93. August 1997. doi:10.1074/jbc.272.32.19785. PMID 9242638.
- "Id helix-loop-helix proteins inhibit nucleoprotein complex formation by the TCF ETS-domain transcription factors". The EMBO Journal 18 (4): 968–76. February 1999. doi:10.1093/emboj/18.4.968. PMID 10022839.
- "Homocysteine-induced endoplasmic reticulum stress and growth arrest leads to specific changes in gene expression in human vascular endothelial cells". Blood 94 (3): 959–67. August 1999. doi:10.1182/blood.V94.3.959.415k20_959_967. PMID 10419887.
- "Id proteins are dynamically expressed in normal epidermis and dysregulated in squamous cell carcinoma". Cancer Research 60 (21): 5929–33. November 2000. PMID 11085505.
- "Opposing effects of Ets and Id proteins on p16INK4a expression during cellular senescence". Nature 409 (6823): 1067–70. February 2001. doi:10.1038/35059131. PMID 11234019. Bibcode: 2001Natur.409.1067O.
- "Protein-protein interaction panel using mouse full-length cDNAs". Genome Research 11 (10): 1758–65. October 2001. doi:10.1101/gr.180101. PMID 11591653.
- "Identification and functional characterization of distinct critically important bone morphogenetic protein-specific response elements in the Id1 promoter". The Journal of Biological Chemistry 277 (7): 4883–91. February 2002. doi:10.1074/jbc.M111023200. PMID 11729207.
- "Modulation of basic helix-loop-helix transcription complex formation by Id proteins during neuronal differentiation". The Journal of Biological Chemistry 277 (11): 9118–26. March 2002. doi:10.1074/jbc.M107713200. PMID 11756408.
- "Constitutive expression of the Id-1 promoter in human metastatic breast cancer cells is linked with the loss of NF-1/Rb/HDAC-1 transcription repressor complex". Oncogene 21 (12): 1812–22. March 2002. doi:10.1038/sj.onc.1205252. PMID 11896613.
- "The MyoD-inducible p204 protein overcomes the inhibition of myoblast differentiation by Id proteins". Molecular and Cellular Biology 22 (9): 2893–905. May 2002. doi:10.1128/MCB.22.9.2893-2905.2002. PMID 11940648.
- "Id-1 stimulates serum independent prostate cancer cell proliferation through inactivation of p16(INK4a)/pRB pathway". Carcinogenesis 23 (5): 721–5. May 2002. doi:10.1093/carcin/23.5.721. PMID 12016143.
- "Down-regulation of Id-1 expression is associated with TGF beta 1-induced growth arrest in prostate epithelial cells". Biochimica et Biophysica Acta (BBA) - General Subjects 1570 (3): 145–52. April 2002. doi:10.1016/S0304-4165(02)00189-7. PMID 12020803.
- "Evidence of increased Id-1 expression and its role in cell proliferation in nasopharyngeal carcinoma cells". Molecular Carcinogenesis 35 (1): 42–9. September 2002. doi:10.1002/mc.10072. PMID 12203366.
External links
- ID1+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
- Overview of all the structural information available in the PDB for UniProt: P20067 (Mouse DNA-binding protein inhibitor ID-1) at the PDBe-KB.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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