Biology:HOXD8
 Generic protein structure example |
Homeobox protein Hox-D8 is a protein that in humans is encoded by the HOXD8 gene.[1][2][3]
This gene belongs to the homeobox family of genes. The homeobox genes encode a highly conserved family of transcription factors that play an important role in morphogenesis in all multicellular organisms. Mammals possess four similar homeobox gene clusters, HOXA, HOXB, HOXC and HOXD, located on different chromosomes, consisting of 9 to 11 genes arranged in tandem. This gene is one of several homeobox HOXD genes located in a cluster on chromosome 2. Deletions that remove the entire HOXD gene cluster or the 5' end of this cluster have been associated with severe limb and genital abnormalities. In addition to effects during embryogenesis, this particular gene may also play a role in adult urogenital tract function.[3]
References
- ↑ "Nomenclature for human homeobox genes". Genomics 7 (3): 460. Aug 1990. doi:10.1016/0888-7543(90)90186-X. PMID 1973146.
- ↑ Scott MP (Dec 1992). "Vertebrate homeobox gene nomenclature". Cell 71 (4): 551–3. doi:10.1016/0092-8674(92)90588-4. PMID 1358459.
- ↑ 3.0 3.1 "Entrez Gene: HOXD8 homeobox D8". https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3234.
Further reading
- Goodman FR (2003). "Limb malformations and the human HOX genes.". Am. J. Med. Genet. 112 (3): 256–65. doi:10.1002/ajmg.10776. PMID 12357469.
- "Human HOX4E: a gene strongly expressed in the adult male and female urogenital tracts.". Genomics 13 (2): 425–30. 1992. doi:10.1016/0888-7543(92)90263-R. PMID 1351871.
- "Complementary homeo protein gradients in developing limb buds.". Genes Dev. 3 (5): 641–50. 1989. doi:10.1101/gad.3.5.641. PMID 2568311.
- "Up-regulation of HOXC6, HOXD1, and HOXD8 homeobox gene expression in human neuroblastoma cells following chemical induction of differentiation.". Tumour Biol. 17 (1): 34–47. 1996. doi:10.1159/000217965. PMID 7501971.
- "The thyroid transcription factor-1 gene is a candidate target for regulation by Hox proteins". EMBO J. 13 (14): 3339–47. 1994. doi:10.1002/j.1460-2075.1994.tb06636.x. PMID 7913891.
- "Dinucleotide repeat polymorphism in the HOX4E locus". Hum. Mol. Genet. 2 (5): 617. 1993. doi:10.1093/hmg/2.5.617. PMID 8100165.
- "Monodactylous limbs and abnormal genitalia are associated with hemizygosity for the human 2q31 region that includes the HOXD cluster". Am. J. Hum. Genet. 65 (1): 104–10. 1999. doi:10.1086/302467. PMID 10364522.
- "Clustering of two fragile sites and seven homeobox genes in human chromosome region 2q31→q32.1". Cytogenet. Cell Genet. 90 (1–2): 151–3. 2000. doi:10.1159/000015651. PMID 11060466.
- "Complete mutation analysis panel of the 39 human HOX genes". Teratology 65 (2): 50–62. 2002. doi:10.1002/tera.10009. PMID 11857506.
- "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. 2003. doi:10.1073/pnas.242603899. PMID 12477932. Bibcode: 2002PNAS...9916899M.
External links
- HOXD8+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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